abstract：:Programmed cell death protein 1 (PD-1) and its ligand PD-L1 are critical for the regulation of T cell exhaustion and activity suppression. Tumor cells expressing immune checkpoints including PD-L1 escape monitoring of T cells from the host immune system. Checkpoint inhibitors are highly promising therapies that functi...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Yan Y,Zhang L,Zuo Y,Qian H,Liu C

更新日期：2020-11-13 00:00:00

abstract：:Osteoarthritis (OA), which is characterized mainly by cartilage degradation, is the most prevalent joint disorder worldwide. Although OA is identified as a major cause of joint pain, disability, and socioeconomic burden, the etiology of OA is still not clearly known. Recently, gene microarray analysis has become an ef...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Liu W,Jiao Y,Tian C,Hasty K,Song L,Kelly DM,Li J,Chen H,Gu W,Liu S

更新日期：2020-09-10 00:00:00

abstract：:We sought to determine whether HLA-A and -B type and haplotype frequencies differ between subgroups of adults with IgG subclass deficiency (IgGSD). We retrospectively compared type and haplotype frequencies of three subgroups of 269 unrelated adult IgGSD patients (70 subnormal IgG1; 121 subnormal IgG3; 78 subnormal Ig...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Barton JC,Barton JC,Bertoli LF,Acton RT

更新日期：2020-04-20 00:00:00

abstract：:The number of studies which evaluated interferon-gamma release assays (IGRAs) results after anti-tuberculosis (TB) treatment has been rapidly increasing. The aim of this study was to investigate the potential use of IGRAs (QFT-GIT, T-SPOT.TB, QFT-Plus) in assessing the response to anti-TB treatment. We searched all st...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Pourakbari B,Mamishi S,Benvari S,Sauzullo I,Bedini A,Valentini P,Keicho N,Mahmoudi S

更新日期：2020-02-03 00:00:00

abstract：:Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are the main autoimmune cholestatic liver diseases. IgG4-associated sclerosing cholangitis is another distinct immune-mediated cholestatic disorder of unknown aetiology that is frequently associated with autoimmune pancreatitis or other IgG4-re...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Dalekos GN,Gatselis NK

更新日期：2019-08-01 00:00:00

abstract：:Stem cells are increasingly being used in the course of burn treatment. As several different types of stem cells are available for the purposes, it is important to chose the most efficient and the most practicable stem cell type. The aim of this study was to compare the potential of heterogeneous amnion cell mixture w...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Kitala D,Klama-Baryła A,Misiuga M,Łabuś W,Kraut M,Szapski M,Lesiak M,Krakowian D,Sieroń AL,Łos MJ,Kucharzewski M

更新日期：2019-06-01 00:00:00

abstract：:Epithelial cells are one of the most actively cycling cells in a mammalian organism and therefore are prone to malignant transformation. Already during organogenesis, the connective tissue (mesenchyme) provides instructive signals for the epithelium. In an adult organism, the mesenchyme is believed to provide crucial ...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Pastuła A,Marcinkiewicz J

更新日期：2019-02-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) survives and proliferates within the main cells of the innate immune system, macrophages. The goal of our study was to investigate the immunostimulatory effects of 13-cis retinoic acid (RA) and chicoric acid (CA) in human U937 macrophages against H37Ra Mtb infection by evaluating its p...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Abd-Nikfarjam B,Nassiri-Asl M,Hajiaghayi M,Naserpour Farivar T

更新日期：2018-10-01 00:00:00

abstract：:Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood. Up to 50% of patients are resistant to standard therapy, which includes non-steroid anti-inflammatory drugs, corticosteroids, disease-modifying anti-rheumatic drugs and biologic therapies. Intra-articular injection of mesen...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Orczyk K,Smolewska E

更新日期：2018-08-01 00:00:00

abstract：:Exaggerated oxidative stress (OS) is usually considered as a disturbance in regular function of an organism. The excessive levels of OS mediators may lead to major damage within the organism's cells and tissues. Therefore, the OS-associated biomarkers may be considered as new diagnostic tools of various diseases. In n...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Krata N,Zagożdżon R,Foroncewicz B,Mucha K

更新日期：2018-06-01 00:00:00

abstract：:The current knowledge on tumor-infiltrating myeloid-derived suppressor cells (MDSCs) is based mainly on the extensive work performed in murine models. Data obtained for human counterparts are generated on the basis of tumor analysis from patient samples. Both sources of information led to determination of the main sup...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Ibáñez-Vea M,Zuazo M,Gato M,Arasanz H,Fernández-Hinojal G,Escors D,Kochan G

更新日期：2018-04-01 00:00:00

abstract：:The progress in melanoma immunotherapy highlights the importance of immunotherapy for cancer treatment. Although the concept of immunotherapy emerged in the beginning of the twentieth century, the end of the century signaled the start of modern immunotherapy, which has recently allowed a staggering progress in the fie...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Rusch T,Bayry J,Werner J,Shevchenko I,Bazhin AV

更新日期：2018-04-01 00:00:00

abstract：:Flow-mediated dilation (FMD) represents a non-invasive marker of endothelial function to evaluate vascular homeostasis, which reflects the effects of several mechanisms, including vessel tone regulation, cell proliferation, and inflammatory responses. Beyond classical atherosclerotic risk factors such as arterial hype...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Moroni L,Selmi C,Angelini C,Meroni PL

更新日期：2017-12-01 00:00:00

abstract：:The original article has been published without acknowledgment section. The acknowledgement section is given below for your reading. ...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Bocian K,Kiernozek E,Domagała-Kulawik J,Korczak-Kowalska G,Stelmaszczyk-Emmel A,Drela N

更新日期：2017-12-01 00:00:00

abstract：:The uniqueness of periodontal diseases is caused by several factors. This group of diseases is caused by numerous bacterial species formed in the dental biofilm, and one cannot distinguish the specific pathogen that is responsible for the disease initiation or progress (though Gram-negative anaerobic rods are associat...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Nędzi-Góra M,Kowalski J,Górska R

更新日期：2017-10-01 00:00:00

abstract：:Acute thymic involution (ATI) is usually regarded as a virulence trait. It is caused by several infectious agents (bacteria, viruses, parasites, fungi) and other factors, including stress, pregnancy, malnutrition and chemotherapy. However, the complex mechanisms that operate during ATI differ substantially from each o...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Ansari AR,Liu H

更新日期：2017-10-01 00:00:00

abstract：:Human cathelicidin, LL-37, is small antimicrobial peptide, which reveals also some immunomodulatory and proangiogenic properties and, therefore, may promote wound healing. The expression of LL-37 is controlled by various factors, including vitamin D. Thus, any disturbances in vitamin D level may influence LL-37 produc...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Krejner A,Litwiniuk M,Grzela T

更新日期：2017-10-01 00:00:00

abstract：:Monoterpenes such as limonene and perillyl alcohol (POH) are promising natural compounds with pro-oxidant properties partly due to endoplasmic reticulum (ER) stress-induced cytotoxicity, and antioxidant activity owing to their activity as free radical scavengers, inhibition of coenzyme Q synthesis, activation of antio...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Gomes AC,Mello AL,Ribeiro MG,Garcia DG,Da Fonseca CO,Salazar MD,Schönthal AH,Quirico-Santos T

更新日期：2017-08-01 00:00:00

abstract：:Type 1 diabetes (T1D) is one of the most studied archetypal organ-specific autoimmune diseases. Although many clinical, epidemiological, and pathological characteristics have been described, there are still important issues which need to be resolved as these will have a major impact on the development of future antige...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Varela-Calvino R,Calviño-Sampedro C,Gómez-Touriño I,Cordero OJ

更新日期：2017-08-01 00:00:00

abstract：:Intravenous and subcutaneous immunoglobulin preparations, consisting of IgG class antibodies, are increasingly used to treat a broad range of pathological conditions, including humoral immune deficiencies, as well as acute and chronic inflammatory or autoimmune disorders. A plethora of Fab- or Fc-mediated immune regul...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Späth PJ,Schneider C,von Gunten S

更新日期：2017-06-01 00:00:00

abstract：:The objective of our study was to evaluate the impact of sex and age on the prevalence of sensitization to inhalant allergens. The study was performed as a part of Polish Epidemiology of Allergic Diseases study, and data concerning citizens of Wroclaw were analyzed. The participants were divided into three age groups ...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Dor-Wojnarowska A,Liebhart J,Miecielica J,Rabski M,Fal A,Samoliński B,Nittner-Marszalska M

更新日期：2017-06-01 00:00:00

abstract：:Recent years of research have shed a new light on the role of IgE in immune reactions. It seems to be more than just a contribution to immediate type of allergic response. It appears that monomeric IgE may enhance mast cell activity without cross-linking of FcεRI by IgE specific allergen or autoreactive IgG anti-IgE a...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Panaszek B,Pawłowicz R,Grzegrzółka J,Obojski A

更新日期：2017-04-01 00:00:00

abstract：:The KIR2DL4 receptor and its ligand HLA-G are considered important for fetal-maternal immune tolerance and successful pregnancy. The absence of a particular variant of KIR2DL4 might be a bad prognostic factor for pregnancy outcome. However, it could be compensated by the presence of the respective LILRB1 allele. There...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Nowak I,Malinowski A,Barcz E,Wilczyński JR,Wagner M,Majorczyk E,Motak-Pochrzęst H,Banasik M,Kuśnierczyk P

更新日期：2016-12-01 00:00:00

abstract：:Distribution of cytochrome P450 2C19 enzyme gene (CYP2C19) variants affecting metabolism of clopidogrel was determined in 526 Czech patients after percutaneous coronary intervention using MassARRAY genotyping and compared to distribution in other populations of European descent. Fifty-three (10%) patients underwent pa...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Petrek M,Kocourkova L,Zizkova V,Nosek Z,Taborsky M,Petrkova J

更新日期：2016-12-01 00:00:00

abstract：:We examined the serum levels of IL-6, IL-8, TNF, IL-6R, TNF-R1, and CRP and the dynamics of changes in these levels according to age. The study included healthy individuals of 20-90 years of age. Participants were divided into subgroups based on their decade of life, and into subgroups of ≥65 or <65 years. Serum cytok...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Wyczalkowska-Tomasik A,Czarkowska-Paczek B,Zielenkiewicz M,Paczek L

更新日期：2016-06-01 00:00:00

abstract：:Colonization of the gastrointestinal tract with multidrug-resistant (MDR) bacteria is a consequence of gut dysbiosis. We describe the successful utilization of fecal microbiota transplantation to inhibit Klebsiella pneumoniae MBL(+) and Escherichia coli ESBL(+) gut colonization in the immunocompromised host as a novel...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Biliński J,Grzesiowski P,Muszyński J,Wróblewska M,Mądry K,Robak K,Dzieciątkowski T,Wiktor-Jedrzejczak W,Basak GW

更新日期：2016-06-01 00:00:00

abstract：:The role of Epstein-Barr virus (EBV) in the biology and clinical characteristics of diffuse large B cell lymphoma (DLBCL) is still poorly defined. A new provisional entity EBV-positive DLBCL of the elderly has been described in Asian population. Its incidence and prognosis remains unknown in middle European patients. ...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Ziarkiewicz M,Wołosz D,Dzieciątkowski T,Wilczek E,Dwilewicz-Trojaczek J,Jędrzejczak WW,Gierej B,Ziarkiewicz-Wróblewska B

更新日期：2016-04-01 00:00:00

abstract：:Pars planitis is defined as an intermediate uveitis of unknown background of systemic disease with characteristic formations such as vitreous snowballs, snowbanks and changes in peripheral retina. The incidence of pars planitis varies 2.4-15.4 % of the uveitis patients. The pathogenesis of the disease is to be determi...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Przeździecka-Dołyk J,Węgrzyn A,Turno-Kręcicka A,Misiuk-Hojło M

更新日期：2016-04-01 00:00:00

abstract：:Studies performed on chimpanzees and humans have revealed that strong, multispecific and sustained CD4(+) and CD8(+) T cell immune responses is a major determinant of hepatitis C virus (HCV) clearance. However, spontaneous elimination of the virus occurs in minority of infected individuals and cellular response direct...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Kaźmierczak J,Caraballo Cortes K,Bukowska-Ośko I,Radkowski M

更新日期：2016-04-01 00:00:00

abstract：:Increases in plasma kynurenic acid (KYNA) concentration relate to the severity of inflammation. The aim of this study was to analyse changes in plasma KYNA concentration and neutrophil/lymphocyte ratio (NLR) in cardiac surgery patients. Additionally, the effect of anaesthesia was analysed. Adult cardiac surgery patien...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Kotlinska-Hasiec E,Nowicka-Stazka P,Parada-Turska J,Stazka K,Stazka J,Zadora P,Dabrowski W

更新日期：2015-04-01 00:00:00

abstract：:Sustained chronic inflammation induces activation of genes involved in cellular proliferation and apoptosis, thereby causing skeletal muscle degeneration. To investigate in vitro effects of isolated pentacyclic triterpenes from Eugenia punicifolia (Ep-CM) upon signaling pathways involved in the regulation of skeletal ...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Leite PE,Lima-Araújo KG,França GR,Lagrota-Candido J,Santos WC,Quirico-Santos T

更新日期：2014-12-01 00:00:00

abstract：:Vascular endothelial growth factor-A (VEGF) is a key regulator of physiological hemangiogenesis during development, postnatal growth, and homeostasis. It is well known that VEGF is required for effective coupling of angiogenesis to endochondral and membranous bone formation during skeletal development. However, less w...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Liu Y,Olsen BR

更新日期：2014-10-01 00:00:00

abstract：:A novel sequence variant, c.240+109C>A, in the Bruton's tyrosine kinase (BTK) gene was identified in a patient with X-linked agammaglobulinemia. This alteration resulted in an incorporation of 106 nucleotides of BTK intron 3 into its mRNA. Administration of the 25-mer antisense morpholino oligonucleotide analog in the...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Rattanachartnarong N,Tongkobpetch S,Chatchatee P,Daengsuwan T,Ittiwut C,Suphapeetiporn K,Shotelersuk V

更新日期：2014-10-01 00:00:00

abstract：:The immune system is deeply interconnected with the endogenous 24-h oscillators of the circadian system. Indeed, the connection between these two physiological systems occurs at multiple levels and in both directions. On one hand, various aspects of the immune system show daily rhythms, which appear to be essential fo...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Cermakian N,Westfall S,Kiessling S

更新日期：2014-08-01 00:00:00

abstract：:Forensic capabilities that provide lead information, and investigative, intelligence, prosecution and policy decision support can be invaluable for responding to and resolving bioterrorism events. Attributing biological attacks through scientific and other resources and processes is an important goal, for which scienc...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Murch RS

更新日期：2014-06-01 00:00:00

abstract：:Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease that has a considerable impact on the quality of life. Alterations in signalling pathways may contribute to the ongoing inflammation and proliferation in CRSwNP. The MEK1/2-ERK1/2 pathway transmits signals from many extracellular molecules to regula...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Linke R,Pries R,Könnecke M,Bruchhage KL,Böscke R,Gebhard M,Wollenberg B

更新日期：2014-06-01 00:00:00

abstract：:The purpose of this study is to evaluate the relationship between the concentration of interleukin-8 (IL-8) in exhaled breath condensate (EBC) and bronchoalveolar lavage fluid (BALF) with the disease activity score and pulmonary function of systemic lupus erythematosus (SLE) patients with and without pulmonary fibrosi...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Nielepkowicz-Goździńska A,Fendler W,Robak E,Kulczycka-Siennicka L,Górski P,Pietras T,Brzeziańska E,Antczak A

更新日期：2014-06-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) are membrane ligand-gated cation channels whose activation is triggered by the binding of the endogenous neurotransmitter acetylcholine or other biologic compounds including nicotine. Their roles in synaptic transmission in the central and peripheral nervous system as well as...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Somm E

更新日期：2014-04-01 00:00:00

abstract：:The worldwide emergence of antibiotic resistances and the drying up of the antibiotic pipeline have spurred a search for alternative or complementary antibacterial therapies. Bacteriophages are bacterial viruses that have been used for almost a century to combat bacterial infections, particularly in Poland and the for...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Verbeken G,Pirnay JP,Lavigne R,Jennes S,De Vos D,Casteels M,Huys I

更新日期：2014-04-01 00:00:00

abstract：:Preterm infants are very susceptible to infections. Immune response mechanisms in this group of patients and factors that influence cord blood mononuclear cell populations remain poorly understood and are considered insufficient. However, competent immune functions of the cord blood mononuclear cells are also describe...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Serwatowska-Bargieł A,Wąsik M,Katarzyna Kornacka M,Górska E,Kozarski R

更新日期：2013-12-01 00:00:00