Abstract:
:The acquisition of specialized skeletal muscle fiber phenotypes during development is investigated by systematic measurement of the accumulation of 21 contractile protein mRNAs during hindlimb development in the rat and the human. During early myotube formation in both species there is no coordination of expression of either fast or slow contractile protein isoform genes, but rather some slow, some fast, and some cardiac isoforms are expressed. Some isoforms are not detected at all in early myotubes. From Embryonic Day 19 in the rat, and after 14 weeks in the human, a strong bias toward fast isoform expression is evident for all gene families examined. This results in the establishment of a coordinated fast isoform phenotype at birth in the rat, and by 24 weeks in the human fetus. Unexpectedly, during secondary myotube formation in the rat we observe sudden rises and falls in contractile protein gene output. We interpret these fluctuations in terms of periods of myoblast proliferation followed by synchronized fusion into myotubes. The data presented indicate that each contractile protein gene has its own determinants of mRNA accumulation and that the different myoblast populations which contribute to the developing limb are not intrinsically programmed to produce particular coordinated phenotypes with respect to the non-myosin heavy chain contractile proteins.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Sutherland CJ,Elsom VL,Gordon ML,Dunwoodie SL,Hardeman ECdoi
10.1016/0012-1606(91)90457-esubject
Has Abstractpub_date
1991-07-01 00:00:00pages
167-78issue
1eissn
0012-1606issn
1095-564Xpii
0012-1606(91)90457-Ejournal_volume
146pub_type
杂志文章abstract::Thyroid hormone (TH) induces dramatic skeletal and tissue remodeling of the anuran head and body at metamorphosis. The expression pattern of TH up-regulated genes has been correlated with tissues that either grow or resorb at metamorphosis. Whereas the expression of the thyroid hormone receptors in Xenopus laevis tadp...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1998.8975
更新日期:1998-11-01 00:00:00
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journal_title:Developmental biology
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
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journal_title:Developmental biology
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journal_title:Developmental biology
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pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2009-08-15 00:00:00
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journal_title:Developmental biology
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.03.008
更新日期:2005-06-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Developmental biology
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pub_type: 杂志文章,评审
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(90)90278-q
更新日期:1990-05-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1998.8963
更新日期:1998-08-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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journal_title:Developmental biology
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00