Evolution of northeastern and midwestern Borrelia burgdorferi, United States.

Abstract:

:The per capita incidence of human Lyme disease in the northeastern United States is more than twice that in the Midwest. However, the prevalence of Borrelia burgdorferi, the bacterium that causes Lyme disease, in the tick vector is nearly identical in the 2 regions. The disparity in human Lyme disease incidence may result from a disparity in the human invasiveness of the bacteria in the Northeast and Midwest caused by fundamentally different evolutionary histories. B. burgdorferi populations in the Northeast and Midwest are geographically isolated, enabling evolutionary divergence in human invasiveness. However, we found that B. burgdorferi populations in the Northeast and Midwest shared a recent common ancestor, which suggests that substantial evolutionary divergence in human invasiveness has not occurred. We propose that differences in either animal ecology or human behavior are the root cause of the differences in human incidence between the 2 regions.

journal_name

Emerg Infect Dis

authors

Brisson D,Vandermause MF,Meece JK,Reed KD,Dykhuizen DE

doi

10.3201/eid1606.090329

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

911-7

issue

6

eissn

1080-6040

issn

1080-6059

journal_volume

16

pub_type

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