Abstract:
:The era of genomics (the study of genes and their function) began a scant dozen years ago with a suggestion by James Watson that the complete DNA sequence of the human genome be determined. Since that time, the human genome project has attracted a great deal of attention in the scientific world and the general media; the scope of the sequencing effort, and the extraordinary value that it will provide, has served to mask the enormous progress in sequencing other genomes. Microbial genome sequencing, of particular interest to the community studying emerging infectious diseases, prompted the series of articles presented in the following pages. These articles review technological and scientific advances that have occurred since publication of the Haemophilus influenzae genome sequence in July 1995; that was the first demonstration that an entire genome sequence could be deciphered by a "shotgun" approach, i.e., the sequencing and assembly of random fragments of the genome. This is now the method of choice for sequencing of most other genomes, including human (as performed by Celera Genomics).
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Schwartz Idoi
10.3201/eid0605.000508subject
Has Abstractpub_date
2000-09-01 00:00:00pages
493-5issue
5eissn
1080-6040issn
1080-6059journal_volume
6pub_type
杂志文章abstract::WU polyomavirus (WUPyV) and KI polyomavirus (KIPyV) are novel human polyomaviruses. They were originally identified in human respiratory secretions, but the extent of human infection caused by these viruses has not been described to date. To determine the seroepidemiology of WUPyV and KIpyIV, we used an ELISA to scree...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1508.090270
更新日期:2009-08-01 00:00:00
abstract::Campylobacter jejuni, a major cause of bacterial foodborne illnesses, is considered highly susceptible to environmental stresses. In this study, we extensively investigated the stress tolerance of 121 clinical strains of C. jejuni against 5 stress conditions (aerobic stress, disinfectant exposure, freeze-thaw, heat tr...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2406.171587
更新日期:2018-06-01 00:00:00
abstract::We isolated Cowpox virus (CPXV) from the ulcerative eyelid lesions of a 14-year-old girl, who had cared for a clinically ill wild rat that later died. CPXV isolated from the rat (Rattus norvegicus) showed complete homology with the girl's virus. Our case is the first proven rat-to-human transmission of cowpox. ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid0812.020089
更新日期:2002-12-01 00:00:00
abstract::The lack of population health surveillance for companion animal populations leaves them vulnerable to the effects of novel diseases without means of early detection. We present evidence on the effectiveness of a system that enabled early detection and rapid response a canine gastroenteritis outbreak in the United King...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2702.202452
更新日期:2021-02-01 00:00:00
abstract::To estimate effectiveness of seasonal trivalent and monovalent influenza vaccines against pandemic influenza A (H1N1) 2009 virus, we conducted a test-negative case-control study in Victoria, Australia, in 2010. Patients seen for influenza-like illness by general practitioners in a sentinel surveillance network during ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1707.101959
更新日期:2011-07-01 00:00:00
abstract::Because of recent interest in bats as reservoirs of emerging diseases, we investigated the presence of viruses in Mystacina tuberculata bats in New Zealand. A novel alphacoronavirus sequence was detected in guano from roosts of M. tuberculata bats in pristine indigenous forest on a remote offshore island (Codfish Isla...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2004.131441
更新日期:2014-04-01 00:00:00
abstract::On April 23, 2009, the New York City Department of Health and Mental Hygiene (DOHMH) was notified of a school outbreak of respiratory illness; 2 days later the infection was identified as pandemic (H1N1) 2009. This was the first major outbreak of the illness in the United States. To guide decisions on the public healt...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1608.091847
更新日期:2010-08-01 00:00:00
abstract::To determine the cause of the recent upsurge in Kyasanur Forest disease, we investigated the outbreak that occurred during December 2011-March 2012 in India. Male patients >14 years of age were most commonly affected. Although vaccination is the key strategy for preventing disease, vaccine for boosters was unavailable...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1902.120544
更新日期:2013-02-01 00:00:00
abstract::During July 2007-June 2015, we enrolled 4,225 hospitalized children with pneumonia in a study to determine the seasonality of respiratory syncytial virus (RSV) infection in Beijing, China. We defined season as the period during which >10% of total PCRs performed each week were RSV positive. We identified 8 distinctive...
journal_title:Emerging infectious diseases
pub_type: 历史文章,杂志文章
doi:10.3201/eid2506.180532
更新日期:2019-06-01 00:00:00
abstract::Mycobacterium tuberculosis isolates cultured from 6 patients associated with an isoniazid-resistant M. tuberculosis outbreak acquired rifampicin resistance. The rpoB gene sequence showed that resistance was associated with rare mutations in each isolate. Three isolates had a mutation outside the rifampicin resistance-...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1106.041262
更新日期:2005-06-01 00:00:00
abstract::Shigella commonly causes gastroenteritis but rarely spreads to the blood. During 2002-2012, we identified 11,262 Shigella infections through population-based active surveillance in Georgia; 72 (0.64%) were isolated from blood. Bacteremia was associated with age >18 years, black race, and S. flexneri. More than half of...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2601.181698
更新日期:2020-01-01 00:00:00
abstract::We have identified Salmonella genomic island I (SGI1) in an isolate of Salmonella enterica serotype Paratyphi B. This antibiotic-resistance gene cluster, which confers multidrug resistance, has been previously identified in S. enterica serotype Typhimurium phage types DT 104 and DT 120 and in S. enterica serotype Agon...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid0804.010375
更新日期:2002-04-01 00:00:00
abstract::We used whole-genome sequence typing (WGST) to investigate an outbreak of Sarocladium kiliense bloodstream infections (BSI) associated with receipt of contaminated antinausea medication among oncology patients in Colombia and Chile during 2013-2014. Twenty-five outbreak isolates (18 from patients and 7 from medication...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2203.151193
更新日期:2016-03-01 00:00:00
abstract::A decision analytical model was developed to investigate the cost-effectiveness of stockpiling antiviral (AV) drugs for a potential influenza pandemic in the United Kingdom and the possible role of near-patient testing in conserving AV drug stocks. Under base-case assumptions (including a fixed stockpile that was smal...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1402.070478
更新日期:2008-02-01 00:00:00
abstract::We report Rickettsia parkeri and Candidatus Rickettsia andeanae in ticks of the Amblyomma maculatum group collected from dogs in Sonora, Mexico. Molecular characterization of these bacteria was accomplished by DNA amplification and sequence analysis of portions of the rickettsial genes gltA, htrA, ompA, and ompB. ...
journal_title:Emerging infectious diseases
pub_type: 信件
doi:10.3201/eid2504.181507
更新日期:2019-04-01 00:00:00
abstract::Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within pat...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid0907.030249
更新日期:2003-07-01 00:00:00
abstract::The mode of transmission of Helicobacter pylori infection is poorly characterized. In northern California, 2,752 household members were tested for H. pylori infection in serum or stool at a baseline visit and 3 months later. Among 1,752 person considered uninfected at baseline, 30 new infections (7 definite, 7 probabl...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1211.060086
更新日期:2006-11-01 00:00:00
abstract::Innovative regulatory and legislative measures to stimulate and facilitate the development of new antimicrobial drugs are needed. We discuss research approaches that can aid regulatory decision making on the treatment of resistant infections and minimization of resistance selection. We also outline current and future ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1202.050078
更新日期:2006-02-01 00:00:00
abstract::We prospectively studied 298 patients with cystic fibrosis (mean age 11.3 years; range 2 months to 32 years; sex ratio, 0.47) for nontuberculous mycobacteria in respiratory samples from January 1, 1996, to December 31, 1999. Mycobacterium abscessus was by far the most prevalent nontuberculous mycobacterium: 15 patient...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid0912.020774
更新日期:2003-12-01 00:00:00
abstract::We report epidemic typhus in a French patient returning from Algeria. The diagnosis was confirmed by serologic testing and the isolation of Rickettsia prowazekii in blood. Initially the patient was thought to have typhoid fever. Because body lice are prevalent in industrialized regions, the introduction of typhus to p...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid0505.990515
更新日期:1999-09-01 00:00:00
abstract::To better define areas of human Lyme disease risk, we compared US surveillance data with published data on the seroprevalence of Borrelia burgdorferi antibodies among domestic dogs. Canine seroprevalence >5% was a sensitive but nonspecific marker of human risk, whereas seroprevalence <1% was associated with minimal ri...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1709.110210
更新日期:2011-09-01 00:00:00
abstract::Staphylococcus aureus bacteremia (SAB) is a major cause of illness and death worldwide. We analyzed temporal trends of SAB incidence and death in Denmark during 2008-2015. SAB incidence increased 48%, from 20.76 to 30.37 per 100,000 person-years, during this period (p<0.001). The largest change in incidence was observ...
journal_title:Emerging infectious diseases
pub_type: 历史文章,杂志文章
doi:10.3201/eid2505.181733
更新日期:2019-05-01 00:00:00
abstract::We identified 131 strains of Vibrio fluvialis among 400 nonagglutinating Vibrio spp. isolated from patients with diarrhea in Kolkata, India. For 43 patients, V. fluvialis was the sole pathogen identified. Most strains harbored genes encoding hemolysin and metalloprotease; this finding may contribute to understanding o...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1811.120520
更新日期:2012-11-01 00:00:00
abstract::Infection by Baylisascaris procyonis is an uncommon but devastating cause of eosinophilic meningitis. We report the first case-patient, to our knowledge, who recovered from B. procyonis eosinophilic meningitis without any recognizable neurologic deficits. The spectrum of illness for this organism may be wider than pre...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1306.061541
更新日期:2007-06-01 00:00:00
abstract::A total of 420 rodents in China were examined for Francisella tularensis by polymerase chain reaction. The infection rates were 4.76% in total, and 11.65%, 10.00%, 6.56%, 1.77%, and 0% in Jilin, Xinjiang, Heilongjiang, Inner Mongolia, and Zhejiang, respectively. Sequence analysis showed that all the detected agents be...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1206.051324
更新日期:2006-06-01 00:00:00
abstract::Reported autochthonous dengue fever transmission in the United States has been limited to 5 south Texas border counties since 1980. We conducted a cross-sectional serosurvey in Brownsville, Texas, and Matamoros, Tamaulipas, Mexico (n = 600), in 2004 to assess dengue seroprevalence. Recent dengue infection was detected...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1310.061586
更新日期:2007-10-01 00:00:00
abstract::From January 1995 through July 1998, we investigated the occurrence of Cyclospora cayetanensis infection associated with gastrointestinal illness or diarrhea in foreign residents and natives of West Java, Indonesia. We found that C. cayetanensis was the main protozoal cause of gastrointestinal illness and diarrhea in ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid0504.990426
更新日期:1999-07-01 00:00:00
abstract::During an 8-year study period, Arcobacter butzleri was the fourth most common Campylobacter-like organism isolated from 67,599 stool specimens. Our observations suggest that A. butzleri displays microbiologic and clinical features similar to those of Campylobacter jejuni; however, A. butzleri is more frequently associ...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1010.040241
更新日期:2004-10-01 00:00:00
abstract::We describe a case of treatment failure caused by a strain of USA300 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with intermediate susceptibility to vancomycin and reduced susceptibility to daptomycin. The strain was isolated from the bone of a 56-year-old man with lumbar osteomyelitis afte...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid1303.060960
更新日期:2007-03-01 00:00:00
abstract::We assessed the effect of closing live poultry markets in China on influenza A(H7N9) virus detection and viability. Intensive sampling was carried out before, during, and after a 2-week citywide market closure; the markets were cleaned and disinfected at the beginning of the closure period. Swab samples were collected...
journal_title:Emerging infectious diseases
pub_type: 杂志文章
doi:10.3201/eid2110.150623
更新日期:2015-10-01 00:00:00