Abstract:
:An outbreak of severe acute respiratory syndrome (SARS) in humans, associated with a new coronavirus, was reported in Southeast Asia, Europe, and North America in early 2003. To address speculations that the virus originated in domesticated animals, or that domestic species were susceptible to the virus, we inoculated 6-week-old pigs and chickens intravenously, intranasally, ocularly, and orally with 106 PFU of SARS-associated coronavirus (SARS-CoV). Clinical signs did not develop in any animal, nor were gross pathologic changes evident on postmortem examinations. Attempts at virus isolation were unsuccessful; however, viral RNA was detected by reverse transcriptase-polymerase chain reaction in blood of both species during the first week after inoculation, and in chicken organs at 2 weeks after inoculation. Virus-neutralizing antibodies developed in the pigs. Our results indicate that these animals do not play a role as amplifying hosts for SARS-CoV.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Weingartl HM,Copps J,Drebot MA,Marszal P,Smith G,Gren J,Andova M,Pasick J,Kitching P,Czub Mdoi
10.3201/eid1002.030677subject
Has Abstractpub_date
2004-02-01 00:00:00pages
179-84issue
2eissn
1080-6040issn
1080-6059journal_volume
10pub_type
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