Abstract:
PURPOSE:To evaluate the effects of intensity of exercise on insulin resistance and the expression of inflammatory proteins in the skeletal muscle of diet-induced obese (DIO) rats after a single bout of exercise. METHODS:In the first exercise protocol, the rats swam for two 3-h bouts, separated by a 45-min rest period (with 6 h in duration--O + EXE), and in the second protocol, the rats were exercised with 45 min of swimming at 70% of the maximal lactate steady state--SS (DIO + MLSS). RESULTS:Our data demonstrated that both protocols of exercise increased insulin sensitivity and increased insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate 1 and serine phosphorylation of protein kinase B in the muscle of DIO rats by the same magnitude. In parallel, both exercise protocols also reduced protein tyrosine phosphatase 1B activity and insulin receptor substrate 1 serine phosphorylation, with concomitant reduction in c-jun N-terminal kinase and IJB kinase activities in the muscle of DIO rats in a similar fashion. CONCLUSIONS:Thus, our data demonstrate that either exercise protocols with low intensity and high volume or exercise with moderate intensity and low volume represents different strategies to restore insulin sensitivity with the same efficacy.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Da Silva AS,Pauli JR,Ropelle ER,Oliveira AG,Cintra DE,De Souza CT,Velloso LA,Carvalheira JB,Saad MJdoi
10.1249/MSS.0b013e3181e45d08subject
Has Abstractpub_date
2010-12-01 00:00:00pages
2180-8issue
12eissn
0195-9131issn
1530-0315journal_volume
42pub_type
杂志文章abstract::Oxidation-reduction (redox) based regulation of gene expression appears to be a fundamental regulatory mechanism in cell biology. This basic information has been exploited to develop novel strategies in clinical therapeutics. In contrast to the conventional idea that reactive species mostly serve as a trigger for oxid...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-200103000-00005
更新日期:2001-03-01 00:00:00
abstract::: The relevance of translational medicine (bringing basic science methods "to the bed of patients") is universally recognized. Too often, however, the tools to be applied translationally are thought to derive only from the "-omics" (genomics, proteomics, transcriptomics, metabolomics, etc.) world. The failures of this...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1249/MSS.0000000000002056
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:The objective of this study is to determine the effects of a caffeine-containing energy drink on female volleyball players' performance. METHODS:Thirteen elite female volleyball players ingested 3 mg·kg of caffeine with an energy drink or the same drink without caffeine (placebo drink) in a double-blind and ra...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000000455
更新日期:2015-04-01 00:00:00
abstract::The purposes of this investigation were to compare selected gait parameters characteristic of running without respiratory apparatus on a treadmill (NOR) with those displayed while wearing a mouthpiece-breathing valve apparatus (MP) and while wearing a respiratory face mask (MASK), and to compare the running economy (R...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1993-02-01 00:00:00
abstract::A decrease in hepatic lactate dehydrogenase (LDH) activity following endurance training has been a consistent observation. In the present study, we sought to determine whether the training-induced decrease in hepatic LDH activity (pyruvate = substrate) was associated with a shift in the isoenzyme profile and/or altera...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract:PURPOSE:A combination of endurance and strength training is generally used to seek further health benefits or enhanced physical performance in older adults compared with either of the training modes alone. The mean change within a training group, however, may conceal a wide range of individual differences in the respon...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181f1bf0d
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:The aim of this study was to compare the biomechanical changes during natural heel-toe running with learned midfoot and Pose running. METHODS:Twenty heel-toe runners were instructed in midfoot running and a novel running style in which the acromium, greater trochanter, and lateral malleolus are aligned in stan...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/01.MSS.0000113684.61351.B0
更新日期:2004-02-01 00:00:00
abstract:UNLABELLED:Exertional heat stroke (EHS) is a state of extreme hyperthermia that occurs when excess heat that is generated by muscular exercise exceeds the body's ability to dissipate it at the same rate. EHS is thought to coincide with previously healthy, highly motivated, and relatively untrained individuals exerting ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199902000-00004
更新日期:1999-02-01 00:00:00
abstract::Exercise and noise exposure causes temporary hearing loss. Yet, a direct relationship may exist between cardiovascular health and hearing. The purpose of this study was to determine whether noise and exercise caused different levels of hearing loss depending on one's cardiovascular fitness. Twenty-eight volunteers wer...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract:PURPOSE:Little is known of the potential long-term gait alterations that occur after an anterior cruciate ligament (ACL) reconstruction. In particular, variables, such as impact loading, which have been previously associated with joint deterioration, have not been studied in walking and running after an ACL reconstruct...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318285c6b6
更新日期:2013-07-01 00:00:00
abstract::The gravity-dependency and age-dependency of noradrenergic vasoconstrictor outflow to skeletal muscle (muscle sympathetic nerve activity; MSNA) in humans was analyzed by applying microneurography technique. The basal level of MSNA in the horizontally supine position increased with aging without significant changes in ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199610000-00039
更新日期:1996-10-01 00:00:00
abstract:PURPOSE:Development of an endurance training-overtraining protocol for Wistar rats that includes increased workload and is characterized by analyses of performance and biomarkers. METHODS:The running protocol lasted 11 wk: 8 wk of daily exercise sessions followed by 3 wk of increasing training frequency (two, three, a...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318191259c
更新日期:2009-05-01 00:00:00
abstract::It has been widely claimed that exercise is beneficial to dysmenorrhea, yet solid evidence is lacking. Studies investigating this relationship have been reviewed for this paper. Most showed decreased prevalence and/or improved symptomatology with exercise. However, controlled longitudinal studies involving women with ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-199806000-00020
更新日期:1998-06-01 00:00:00
abstract:PURPOSE:This study, theoretically based on the Exercise Self-Esteem Model, EXSEM, examined effects of exercise modality on physical and global self-esteem (PSE, GSE) in breast cancer survivors. The EXSEM posits GSE at the apex with PSE feeding into GSE. PSE has three subdomains: physical condition (PC), attractive body...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0b013e31822cb5f2
更新日期:2012-02-01 00:00:00
abstract:INTRODUCTION:The GENEA shows high accuracy for classification of sedentary, household, walking, and running activities when sampling at 80 Hz on three axes. It is not known whether it is possible to decrease this sampling frequency and/or the number of axes without detriment to classification accuracy. The purpose of t...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31825e19fd
更新日期:2012-11-01 00:00:00
abstract:INTRODUCTION:A nonlinear dynamic systems model has previously been proposed to explain pacing strategies employed during exercise. PURPOSE:This study was conducted to examine the pacing strategies used under varying conditions during the cycle phase of an Ironman triathlon. METHODS:The bicycles of six well-trained ma...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000210202.33070.55
更新日期:2006-04-01 00:00:00
abstract:PURPOSE:Methicillin-resistant Staphylococcus aureus (MRSA) has been recognized as a serious skin infection in the athletic population. Literature in reference to football players has been sparse. We sought to better elucidate circumstances surrounding such infections in collegiate football players. METHODS:Data from t...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1249/MSS.0b013e31816f1534
更新日期:2008-08-01 00:00:00
abstract:PURPOSE:The aim of this study was to test whether a tidally ventilated homogeneous lung model can correctly describe arterial and end-tidal gas partial pressures and thus the difference in end-tidal and arterial gas partial pressures at rest and during exercise. METHODS:The implemented mathematical modeling described ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200204000-00010
更新日期:2002-04-01 00:00:00
abstract:PURPOSE:The purpose of this project was to determine the incidence of exercise-induced bronchospasm (EIB) among U.S. Olympic winter sport athletes. METHODS:Subjects included female and male members of the 1998 U.S. Winter Olympic Team from the following sports: biathlon, cross-country ski, figure skating, ice hockey, ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200004000-00003
更新日期:2000-04-01 00:00:00
abstract:PURPOSE:The purpose of this study was to investigate neuromuscular characteristics and muscle power as determinants of distance running performance. METHODS:Seventeen male endurance athletes performed a 5-km time trial (5K) that included three separate constant-velocity 200-m laps during the course and a maximal 20-m ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199901000-00020
更新日期:1999-01-01 00:00:00
abstract:INTRODUCTION:Alternative high school (AHS) students are an underserved population of youth at greater risk for poor health behaviors and outcomes. Little is known about their physical activity patterns. PURPOSE:: The purpose of this study was to describe 1) physical activity levels of students attending alternative hi...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318182092b
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:Recent literature suggests that subconcussive impacts may influence cognitive functioning across the life span. These effects are suggested to manifest as functional and possibly structural changes. Head impact biomechanics during American football have been characterized from the high school to professional le...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3182798758
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:One approach to studying the effects of aging on physiological functional capacity (PFC) in humans is to analyze the peak physical performance of trained athletes with increasing age. The primary aim of the present study was to determine weightlifting and powerlifting performance with increasing age in both men...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000106283.34742.BE
更新日期:2004-01-01 00:00:00
abstract:PURPOSE AND METHODS:It is commonly recognized that there is familial aggregation for physical activity level. However, the genes and sequence variants responsible for the familial clustering have not been investigated. We performed a genome-wide linkage scan based on 432 markers typed in 767 subjects from 207 families ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000078937.22939.7E
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:Heart rate (HR) is widely used to adjust exercise intensity in aerobic training. Training HR recommendations are calculated often from simple equations. Because at lactate steady state (LASS) may be an intensity of exercise eliciting similar objective measures of intensity and similar subjective measures of met...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200205000-00024
更新日期:2002-05-01 00:00:00
abstract:UNLABELLED:Two recently identified glucose transporters, GLUT8 and GLUT12, are expressed in human skeletal muscle and may be involved in insulin-mediated sugar transport. PURPOSE:The purpose of this study was to measure GLUT8 and GLUT12 mRNA levels in endurance-trained versus sedentary individuals in an effort to dete...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000222837.74015.f1
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:Aerobic training (AT) and high-intensity intermittent training (HIIT) reduce arterial stiffness, whereas resistance training (RT) induces deterioration of or no change in arterial stiffness. However, the molecular mechanism of these effects of different exercise modes remains unclear. This study aimed to clarif...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000001567
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION:Despite the widespread utilization of the Balance Error Scoring System (BESS) in the evaluation of concussion, it has been criticized for its error-based scoring that is susceptible to floor and ceiling effects and substantial inter-rater variability. A biomechanical outcome, Cleveland Clinic Postural Stab...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001660
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Data from the general population suggest that habitual exercise decreases bronchial responsiveness, but the possible role of exercise in asthmatics is undefined. The leukotriene receptor antagonist montelukast decreases bronchial responsiveness and exercise-induced symptoms in asthmatic children. This randomize...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0b013e31815d9670
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:The main purpose of the present investigation was to test whether and to what extent familial/genetic factors are involved in the changes of postheparin lipoprotein lipase (deltaPH-LPL) activity and triglyceride (deltaTG) levels in response to exercise training. Additional hypotheses were also tested as to whet...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200008000-00012
更新日期:2000-08-01 00:00:00