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Familiality of triglyceride and LPL response to exercise training: the HERITAGE study.

Abstract：

PURPOSE:The main purpose of the present investigation was to test whether and to what extent familial/genetic factors are involved in the changes of postheparin lipoprotein lipase (deltaPH-LPL) activity and triglyceride (deltaTG) levels in response to exercise training. Additional hypotheses were also tested as to whether there were familial/genetic factors shared by baseline and the corresponding response to exercise training (i.e., by baseline triglyceride (TG(B)) and deltaTG and by baseline postheparin lipoprotein lipase (PH-LPL(B)) and deltaPH-LPL activity). METHODS:Serum TG and PH-LPL were measured in 459 subjects from 99 sedentary Caucasian families of the HERITAGE Family study before (baseline) and after completing a 20 wk (3 times per week) exercise training protocol. The training protocol had a target intensity of 75% of the heart rate associated with baseline VO2max during the last 6 wk. PH-LPL activity was measured in the study subjects. Both univariate and bivariate familial correlation analyses were applied to the baseline and response data. RESULTS:The maximal heritabilities for deltaTG and deltaPH-LPL activity were 22% and 15%, respectively. There were no common familial factors for TG(B) and deltaTG, nor were there any for PH-LPL(B) and deltaPH-LPL. However, we found that there were common familial factors underlying deltaTG and deltaPH-LPL; these familial factors seemed to differ across sex and generation groups. CONCLUSION:Although there were no common familial factors underlying the covariation between the baseline triglyceride and PH-LPL activity and the corresponding responses to exercise training (i.e., TG(B) with deltaTG or PH-LPL(B) with deltaPH-LPL), the deltaTG and deltaPH-LPL covariation apparently share some common familial determinants.

journal_name

Med Sci Sports Exerc

journal_title

Medicine and science in sports and exercise

authors

Hong Y,Rice T,Gagnon J,Pérusse L,Province M,Bouchard C,Leon AS,Skinner JS,Wilmore JH,Rao DC,Després JP

doi

10.1097/00005768-200008000-00012

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

1438-44

issue

eissn

0195-9131

issn

1530-0315

journal_volume

pub_type

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Familiality of triglyceride and LPL response to exercise training: the HERITAGE study.