Abstract:
:: The relevance of translational medicine (bringing basic science methods "to the bed of patients") is universally recognized. Too often, however, the tools to be applied translationally are thought to derive only from the "-omics" (genomics, proteomics, transcriptomics, metabolomics, etc.) world. The failures of this "reductionist" approach are widely recognized. In the review, we discuss studies demonstrating that scientifically sound mechanistic insights into diseases, relevant both in terms of basic science and clinically, and very well suited to be utilized within a translational medicine approach, can be obtained from the established field of exercise physiology. Methods originally aimed toward basic physiological mechanisms, and applied for the functional evaluation of athletes and sport performance, can have a valuable translational application in patients with metabolic myopathies; such as myophosphorylase deficiency (McArdle disease) or mitochondrial myopathies, diseases which share the common denominator of an impaired skeletal muscle oxidative metabolism. Several variables can yield pathophysiological insights, can identify and quantify the metabolic impairment and the effects on exercise tolerance (one of the main determinants of the patients' clinical picture and quality of life), and can offer diagnostic clues: the impaired capacity of O2 extraction by skeletal muscle, evaluated by near-infrared spectroscopy; the "exaggerated" cardiovascular response to exercise; the slower speed of adjustment of oxidative metabolism during metabolic transitions; the "slow component" of pulmonary O2 uptake kinetics and the associated reduced efficiency and fatigue; the impaired intramuscular matching between O2 delivery and O2 utilization. The proposed methods are noninvasive, and therefore facilitate repeated or serial evaluations. They provide support for a simple message: physiology and physiological research remain the essential link between genes, molecules, and clinical care.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Grassi B,Porcelli S,Marzorati Mdoi
10.1249/MSS.0000000000002056subject
Has Abstractpub_date
2019-11-01 00:00:00pages
2183-2192issue
11eissn
0195-9131issn
1530-0315pii
00005768-201911000-00001journal_volume
51pub_type
杂志文章,评审abstract:BACKGROUND:Interactive video game exercise leads to improved exercise adherence and health-related physical fitness in comparison to traditional stationary cycling. It has been postulated that interactive video game exercise has greater metabolic requirements than traditional cycling; however, this has not been tested ...
journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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doi:
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1992-11-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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doi:10.1249/MSS.0b013e3181fec518
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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更新日期:1984-06-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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更新日期:1992-11-01 00:00:00
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pub_type: 杂志文章,评审
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