Abstract：
:A decrease in hepatic lactate dehydrogenase (LDH) activity following endurance training has been a consistent observation. In the present study, we sought to determine whether the training-induced decrease in hepatic LDH activity (pyruvate = substrate) was associated with a shift in the isoenzyme profile and/or alteration in other kinetic parameters. Animals (rats) were randomly assigned to either an endurance trained group (running 90 min at 30 m.min-1, 10% grade) or sedentary control group. Eight weeks of endurance training resulted in a significant decrease in maximal hepatic LDH activity for the forward reaction (pyruvate-->lactate), 107.3 +/- 5.5 mumol.min-1.g-1, when compared with control animals, 147.3 +/- 5.6 mumol.min-1.g-1. A similar decrease was observed for maximal LDH activity in the reverse reaction (lactate-->pyruvate), 49.8 +/- 2.1 vs 66.7 +/- 2.9 mumol.min-1.g-1, trained and controls, respectively. Training was also observed to decrease the Km for the reverse reaction, 5.18 +/- 0.78 mM vs 6.94 +/- 0.55 mM, for trained and controls, respectively. Km for the forward reaction was unaffected by training. Gel electrophoresis with densitometric evaluation revealed no shift in the isoenzyme pattern following endurance training. LDH5 accounted for 89% +/- 2%, whereas 6% +/- 0.5% was observed in LDH4, and 4% +/- 0.3% was observed in LDH3 for both groups. The densitometric area was approximately 34% lower from trained liver homogenates, a fractional decrease similar to that observed for maximal LDH activity. The decrease in hepatic LDH activity with endurance training appears attributable to a down regulation of enzyme content, with no significant alteration in isoenzyme distribution.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Sumida KD,Frisch F,Donovan CMsubject
Has Abstractpub_date
1995-04-01 00:00:00pages
507-11issue
4eissn
0195-9131issn
1530-0315journal_volume
27pub_type
杂志文章abstract：INTRODUCTION & PURPOSE:Obesity-related increases of weight on the chest wall are known to decrease lung volume and chest wall compliance, but the effect of this mass loading, independent of other obesity-related complications on the ventilatory response to exercise is unknown. The purpose of this study was to investiga...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000126386.12402.f5
更新日期：2004-05-01 00:00:00
abstract：:The effect of physical exercise and vitamin C on iron absorption after oral iron administration was investigated. Eight healthy male subjects without iron deficiency were studied after administration of 100 mg ferric sodium citrate complex, 100 mg ferric sodium citrate complex with 200 mg ascorbic acid, and without ir...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：10.1097/00005768-199612000-00005
更新日期：1996-12-01 00:00:00
abstract：PURPOSE:Power training plays an essential part in many sport disciplines. The importance of eccentric power training remains a matter of controversial discussion. The objective of this study was therefore to investigate the difference in metabolic reaction between eccentric and concentric stress in comparable work. ME...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200105000-00018
更新日期：2001-05-01 00:00:00
abstract：PURPOSE:This study aimed to evaluate the relationship between race car cockpit temperature and thermal strain indicators among race car drivers. METHODS:Four male racing drivers' heart rate (HR), skin temperature (Tskin), and core temperature (Tcore) were measured continuously using the Equivital Life Monitor bio harn...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000002483
更新日期：2021-02-01 00:00:00
abstract：:Anthropometric and demographic characteristics are important determinants of exercise performance in healthy subjects, but their influence has not yet been studied in severe chronic heart failure, although peak oxygen uptake is frequently assessed in such patients for prognostic purposes. The aim of the present analys...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199706000-00002
更新日期：1997-06-01 00:00:00
abstract：INTRODUCTION:Parents play a critical role in shaping children's attitudes, beliefs, and behaviors, including those around physical activity and inactivity. Our ability to identify which practices effectively promote children's physical activity and limit inactivity is limited by existing measurement instruments. This p...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e31829d27de
更新日期：2013-12-01 00:00:00
abstract：:Since the first reported use of knee braces for prophylactic purposes in 1979, these braces have gone through a period of widespread popularity and use, followed by increasing skepticism as to their effectiveness. Early use was unsupported by significant clinical or laboratory data. Multiple studies regarding prophyla...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,评审
doi：
更新日期：1991-07-01 00:00:00
abstract：PURPOSE:A cyclical operational model is proposed to examine the interrelationship of a number of factors that are involved in sports injury epidemiology. In sports injury research, investigations often attempt to identify a unique risk factor that distinguishes an injured player. However, a wide variety of factors can ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200112000-00004
更新日期：2001-12-01 00:00:00
abstract：PURPOSE:Physical activity questionnaires (PAQs) are considered the most cost-efficient method to estimate total energy expenditure (TEE) in epidemiological studies. However, relatively few PAQs have been validated using doubly labeled water (DLW) in women or in samples with diverse ethnic backgrounds. This study was co...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：10.1097/00005768-200111000-00024
更新日期：2001-11-01 00:00:00
abstract：PURPOSE:The study's purposes were to 1) assess changes in cardiorespiratory fitness (CRF) from 1998 to 2010, controlling for decimal age and body mass index (BMI), and 2) repeat the analysis in cohorts from 2005 to 2010, controlling for maturation, deprivation, and BMI. METHODS:A total of 27,942 (n = 14,247 boys) 9- t...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3182300267
更新日期：2012-03-01 00:00:00
abstract：UNLABELLED:Exertional heat stroke (EHS) is a state of extreme hyperthermia that occurs when excess heat that is generated by muscular exercise exceeds the body's ability to dissipate it at the same rate. EHS is thought to coincide with previously healthy, highly motivated, and relatively untrained individuals exerting ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199902000-00004
更新日期：1999-02-01 00:00:00
abstract：PURPOSE:Arterial distensibility decreases with age. This decrease may be associated with the initiation and/or progression of hypertension and atherosclerosis and may be attenuated by positive lifestyle habits, including habitual physical activity. We tested the hypothesis that self-reported sport, leisure, and work ph...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200112000-00014
更新日期：2001-12-01 00:00:00
abstract：PURPOSE:The effect of quantified resistance and high impact exercise training on bone mass as modified by age and oral contraceptive (OCont) use in young women was studied. METHODS:Women were categorized by age (18-23 vs 24-31 yr) and OCont use, and were then randomized into either three sessions of resistance exercis...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00005768-200106000-00004
更新日期：2001-06-01 00:00:00
abstract：PURPOSE:Accurate and reliable measurement of physical activity plays an important role in assessing effective lifestyle interventions for obesity. This study examined reliability of accelerometer-based estimates of physical activity levels of overweight and obese adults before and after a lifestyle weight loss program....
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181846cd8
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:Pedometers may provide valuable information regarding the ambulatory patterns of adolescents, but the effects of body mass index (BMI) on pedometer accuracy in this population are unknown.The purpose of this study was twofold: 1) to determine whether the New Lifestyles NL-2000 (NL) and the Digi-Walker SW-200 (D...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3182746aa5
更新日期：2013-03-01 00:00:00
abstract：:Running technique and economy (VO2submax) were examined before and after a 6-wk period of running training. Fifteen males were filmed and performed 10-min economy runs at 3.36 m.s-1 on a treadmill. An incremental treadmill test was used to record running performance and maximal oxygen consumption (VO2max). Subjects we...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00005768-199607000-00013
更新日期：1996-07-01 00:00:00
abstract：INTRODUCTION:Androgen deprivation therapy (ADT) is associated with significant bone loss and an increase in fracture risk among prostate cancer survivors (PCS). We investigated whether impact + resistance training could stop ADT-related declines in bone mineral density (BMD) among PCS on ADT. METHODS:We randomized 51 ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0000000000000265
更新日期：2014-08-01 00:00:00
abstract：PURPOSE:Tibial stress fracture is a common overuse running injury that results from the interplay of repetitive mechanical loading and bone strength. This research project aimed to determine whether female runners with a history of tibial stress fracture (TSF) differ in ground reaction force (GRF) parameters during run...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000117116.90297.e1
更新日期：2004-03-01 00:00:00
abstract：PURPOSE:This investigation assessed the effects of a 9-wk regimen of creatine monohydrate (Cr x H2O) supplementation coupled with resistance training on body composition and neuromuscular performance in NCAA Division I football athletes. METHODS:Twenty-five subjects were randomly assigned in a double-blind, randomized...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00005768-200110000-00009
更新日期：2001-10-01 00:00:00
abstract：:The purpose of this investigation was to determine the influence of post-exercise carbohydrate (CHO) intake on the rate of muscle glycogen resynthesis after high intensity weight resistance exercise in subjects not currently weight training. In a cross-over design, eight male subjects performed sets (mean = 8.8) of si...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:The effects of the potent opioid, sufentanil, were studied in 11 athletes. Sufentanil was administered intravenously (up to 0.5 microgram.kg-1 over 10 min) to the subjects while they ran at 14 km.hr-1 on a level treadmill. Prior to, and after, the drug infusion, the treadmill was inclined by 6% for 4 min and CO2 was i...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
abstract：PURPOSE:Endurance training improves skeletal muscular function including energy metabolism and structure. Sex steroid hormones partly contribute to the exercise-induced muscular adaptations. Recently, we demonstrated that skeletal muscle contains steroidogenic converting enzymes to synthesize sex steroid hormones and a...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e31821e9d74
更新日期：2011-11-01 00:00:00
abstract：:The kinetics of gas exchange at the on-transient of exercise are appreciably slowed in older individuals. Eight older men (72 yr) completed 6 months of aerobic cycle training. Ventilation and gas exchange kinetics were determined at the onset of a below threshold (ventilatory threshold, V(E)T) square wave exercise fun...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:Muscle fatigue has been studied with a variety approaches, tools and technologies. The foci of these studies have ranged tremendously, from molecules to the entire organism. Single cell and animal models have been used to gain mechanistic insight into the fatigue process. The theme of this review is the concept that t...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,评审
doi：10.1249/MSS.0000000000001052
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:Compelling evidence suggests larger performance decrements during hypoxic versus normoxic repeated sprinting. Yet the underlying mechanical alterations have not been thoroughly investigated. Therefore, we examined the effects of different levels of normobaric hypoxia on running mechanical performance during rep...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0000000000000937
更新日期：2016-08-01 00:00:00
abstract：:To determine the effects of anabolic steroids on myocardial structure, VO2max, and body composition, experienced age-matched male weight trainers (M age 26.5 yr) who either used (U) (N = 11) or did not use (NU) (N = 13) anabolic steroids were evaluated. Steroid users were tested while off cycle (U-OFF) for at least 8 ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:The inheritance of cardiac changes during acute dynamic physical exercise was studied in 21 pairs of monozygotic and 12 pairs of dizygotic male twins, ages 18-31 yr. Echocardiography was performed in resting conditions and at submaximal supine bicycle exercise at a heart rate of 110 bpm. In resting conditions signific...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：PURPOSE:We tested the hypothesis that critical velocity (CV) during intermittent running with changes of direction is reliably and accurately identified from a simple shuttle field test. We also tested the hypothesis that CV during intermittent running with changes of direction running is not equivalent to continuous l...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001774
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:To assess the biologic basis of massage therapies, we developed an experimental approach to mimic Swedish massage and evaluate this approach on recovery from eccentric exercise-induced muscle damage using a well-controlled animal model. METHODS:Tibialis anterior muscles of six New Zealand White rabbits were su...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e31816c4e12
更新日期：2008-07-01 00:00:00
abstract：PURPOSE:Maximizing carbohydrate availability is important for many endurance events. Combining pectin and sodium alginate with ingested maltodextrin-fructose (MAL + FRU + PEC + ALG) has been suggested to enhance carbohydrate delivery via hydrogel formation, but the influence on exogenous carbohydrate oxidation remains ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0000000000002262
更新日期：2020-06-01 00:00:00
