Abstract:
PURPOSE:To report a case of bilateral regression of choroidal metastasis with adenocarcinoma of the lung treated with gefitinib. METHODS:Retrospective case review of a 68-year-old woman with pulmonary adenocarcinoma with choroidal metastasis who presented with visual loss in the left eye as the initial manifestation. Her visual acuity was 6/6 in the right eye and 6/60 in the left eye before the start of gefitinib administration. Best-corrected visual acuity and spectral-domain optical coherence tomography were compared between baseline and 3 months after treatment. RESULTS:Best-corrected visual acuity in the left eye had improved to 6/30 3 months after oral gefitinib. The elevated lesions of the right eye disappeared, with decrease of subretinal fluid and retinal pigment epithelial atrophy. Spectral-domain optical coherence tomography showed that subretinal fluid of the left eye was also reduced. CONCLUSIONS:Oral gefitinib could be effective for regression of choroidal metastasis in patients with adenocarcinoma of the lung and provides a potential treatment option.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Inoue M,Watanabe Y,Yamane S,Kobayashi S,Arakawa A,Tsukahara T,Kaneko T,Kadonosono Kdoi
10.1177/112067211002000526subject
Has Abstractpub_date
2010-09-01 00:00:00pages
963-5issue
5eissn
1120-6721issn
1724-6016pii
6BFD76E3-D3ED-4765-BF17-17B5C76DDEA0journal_volume
20pub_type
杂志文章abstract:PURPOSE:The authors report the ophthalmic characteristics of a male proband in a Japanese family with autosomal dominant optic atrophy (DOA) harboring a frameshift mutation in the OPA1 gene. METHODS:Conventional ophthalmologic examinations including static automated perimetry were performed, as well as assessment of t...
journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
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更新日期:1993-01-01 00:00:00
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