Treatment induced necrosis versus recurrent/progressing brain tumor: going beyond the boundaries of conventional morphologic imaging.

abstract：PURPOSE:Although the survival of most melanoma patients diagnosed with leptomeningeal disease (LMD) is short, some patients can have better outcomes and prolonged survival. A large retrospective cohort of patients was analyzed to identify features associated with survival with LMD from melanoma. METHODS:Clinical chara...

journal_title：Journal of neuro-oncology

authors： Ferguson SD,Bindal S,Bassett RL Jr,Haydu LE,McCutcheon IE,Heimberger AB,Li J,O'Brien BJ,Guha-Thakurta N,Tetzlaff MT,Tawbi H,Davies MA,Glitza IC

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Therapeutic intervention at glioblastoma (GBM) progression, as defined by current assessment criteria, is arguably too late as second-line therapies fail to extend survival. Still, most GBM trials target recurrent disease. We propose integration of a novel imaging biomarker to more confidently and promptly defi...

journal_title：Journal of neuro-oncology

authors： Gatson NTN,Bross SP,Odia Y,Mongelluzzo GJ,Hu Y,Lockard L,Manikowski JJ,Mahadevan A,Kazmi SAJ,Lacroix M,Conger AR,Vadakara J,Nayak L,Chi TL,Mehta MP,Puduvalli VK

更新日期：2020-07-01 00:00:00

abstract：:Radiation (RT) is critical to the treatment of high-grade gliomas (HGGs) but cures remain elusive. The BRAF mutation V600E is critical to the pathogenesis of 10-20% of pediatric gliomas, and a small proportion of adult HGGs. Here we aim to determine whether PLX4720, a specific BRAF V600E inhibitor, enhances the activi...

journal_title：Journal of neuro-oncology

authors： Dasgupta T,Olow AK,Yang X,Hashizume R,Nicolaides TP,Tom M,Aoki Y,Berger MS,Weiss WA,Stalpers LJ,Prados M,James CD,Mueller S,Haas-Kogan DA

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:The purpose of this study is to map spatial metabolite differences across three molecular subgroups of glial tumors, defined by the IDH1/2 mutation and 1p19q-co-deletion, using magnetic resonance spectroscopy. This work reports a new MR spectroscopy based classification algorithm by applying a radiomics anal...

journal_title：Journal of neuro-oncology

authors： Diamandis E,Gabriel CPS,Würtemberger U,Guggenberger K,Urbach H,Staszewski O,Lassmann S,Schnell O,Grauvogel J,Mader I,Heiland DH

更新日期：2018-09-01 00:00:00

abstract：:This adjunct to a prospective phase II blinded study of 48 patients with recurrent malignant glioma evaluated the predictive reliability of an extreme drug resistance (EDR) to identify clinical resistance to irinotecan (CPT-11), using fresh tumor biopsies obtained from recurrent patients immediately prior to their fir...

journal_title：Journal of neuro-oncology

authors： Parker RJ,Fruehauf JP,Mehta R,Filka E,Cloughesy T

更新日期：2004-02-01 00:00:00

abstract：:Intravascular lymphomatosis (IL) is a rare entity only recently included in lymphoma classification, whose main feature is the exclusive or predominant growth of neoplastic cells within blood vessels. The vast majority of the patients affected by IL belong to the 7th or 8th decade of life and present with skin rash or...

journal_title：Journal of neuro-oncology

authors： Massimino M,Giardini R,Cefalo G,Simonetti F,Pollo B,Giombini S,Tesoro-Tess JD,Ponzoni M,Patriarca C

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:To analyze the surgical outcome of a consecutive and single center series of medulla oblongata (MO) and spinal cord hemangioblastomas (HB). PATIENT AND METHODS:We retrospectively reviewed the medical charts of all MO and spinal HB patients operated on in our institution between 1985 and 2002. All patients had ...

journal_title：Journal of neuro-oncology

authors： Parker F,Aghakhani N,Ducati LG,Yacubian-Fernandes A,Silva MV,David P,Richard S,Tadie M

更新日期：2009-05-01 00:00:00

abstract：:One objection to using cell cultures for studying the proliferation of tumors is the potential for phenotypic changes that may occur in vitro. Here, we compared the antigen pattern expression of cultured meningioma cells with that of the primary tumor. Cell cultures established from 9 intracranial meningiomas and depa...

journal_title：Journal of neuro-oncology

authors： Pallini R,Casalbore P,Mercanti D,Maggiano N,Larocca LM

更新日期：2000-08-01 00:00:00

abstract：:The optimal treatment of recurrent glioblastoma (GBM) in elderly patients is unclear. Fotemustine (FTM) is a third-generation nitrosourea showing efficacy in gliomas and it has been used with different schedules in adult patients. We performed, for the first time anywhere, a mono-institutional retrospective study to a...

journal_title：Journal of neuro-oncology

authors： Lombardi G,Bellu L,Pambuku A,Della Puppa A,Fiduccia P,Farina M,D'Avella D,Zagonel V

更新日期：2016-07-01 00:00:00

abstract：:We have developed an in vitro assay for Natural Killer (NK) cell cytolysis of and binding to substrate attached human glioma and fetal brain cells. The monolayer cells were labeled with [51Cr] and the effectors were directly sedimented onto these substrate attached target cells. Using this method we screened several g...

journal_title：Journal of neuro-oncology

authors： Kazimer RM,Whisler RL,Stephens RE,Pearl DK,Yates AJ

更新日期：1989-07-01 00:00:00

abstract：:Neuroblastoma (NB) is a tumor of pediatric age that is associated with high mortality in metastatic stages, although stage IVS patients undergo frequent spontaneous regression. Since apoptosis has been proposed as a possible cause of remission among cancer patients, we tested this hypothesis among both localized and m...

journal_title：Journal of neuro-oncology

authors： Tonini GP,Mazzocco K,di Vinci A,Geido E,de Bernardi B,Giaretti W

更新日期：1997-01-01 00:00:00

abstract：:Aberrant expression of stem cell-related genes in tumors may confer more primitive and aggressive traits affecting clinical outcome. Here, we investigated expression and prognostic value of the neural stem cell marker CD133, as well as of the pluripotency genes LIN28 and OCT4 in 37 samples of pediatric medulloblastoma...

journal_title：Journal of neuro-oncology

authors： Rodini CO,Suzuki DE,Saba-Silva N,Cappellano A,de Souza JE,Cavalheiro S,Toledo SR,Okamoto OK

更新日期：2012-01-01 00:00:00

abstract：:Gliomatosis cerebri (GC) is regarded as a rare glial neoplasm of unknown origin, and a detailed analysis of molecular alterations underlying this disease has started only recently. However, because GC characteristically affects large parts of the brain and spinal cord, the distribution of genetic alterations may be hi...

journal_title：Journal of neuro-oncology

authors： Mawrin C,Kirches E,Schneider-Stock R,Boltze C,Vorwerk CK,von Mawrin A,Kirches E,Schneider-Stock R,Boltze C,Vorwerk CK,von Mawrin A,Kirches E,Schneider-Stock R,Boltze C,Vorwerk CK,von Mawrin A,Kirches E,Schneider-Stock R

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:Children with recurrent medulloblastoma have a poor prognosis. Re-irradiation is an option for some patients, but has not been well-studied in the era of molecular characterization for pediatric medulloblastoma. METHODS:This was a retrospective cohort study of 14 children age 18 years and younger at initial di...

journal_title：Journal of neuro-oncology

authors： Tsang DS,Sarhan N,Ramaswamy V,Nobre L,Yee R,Taylor MD,Hawkins C,Bartels U,Huang A,Tabori U,Hodgson DC,Bouffet E,Laperriere N

更新日期：2019-10-01 00:00:00

abstract：:The diagnosis of brain metastases is associated with a poor prognosis reflecting uncontrolled primary disease that has spread to the relative sanctuary of the central nervous system. 20 % of brain metastases occur in the posterior fossa and are associated with significant morbidity. The risk of acute hydrocephalus and...

journal_title：Journal of neuro-oncology

authors： Sunderland GJ,Jenkinson MD,Zakaria R

更新日期：2016-12-01 00:00:00

abstract：:Hepatoma-derived growth factor (HDGF) is a neurotrophic factor found in mouse spinal cord and hippocampal neurons. In various malignant tumors, the role of HDGF in tumor progression and its use as a diagnostic biomarker or therapeutic target have been extensively explored. However, the prognostic function and mitogeni...

journal_title：Journal of neuro-oncology

authors： Hsu SS,Chen CH,Liu GS,Tai MH,Wang JS,Wu JC,Kung ML,Chan EC,Liu LF

更新日期：2012-03-01 00:00:00

abstract：:The labeling index (LI) of 216 cases of human brain tumors was determined by the immunohistochemical technique with monoclonal antibody to bromodeoxyuridine (BrdU). The proliferative potential of 110 cases was estimated using the intra-operative intravenous infusion of BrdU at a dose of 200 mg/sq m. In another 106 cas...

journal_title：Journal of neuro-oncology

authors： Kharbanda K,Dinda AK,Sarkar C,Karak AK,Dhir R,Mathur M,Roy S

更新日期：1995-01-01 00:00:00

abstract：:Radiation therapy (RT) for brain tumors is associated with neurocognitive toxicity which may be a result of damage to neural progenitor cells (NPCs). We present a novel technique to limit the radiation dose to NPC without compromising tumor coverage. A study was performed in mice to examine the rationale and another w...

journal_title：Journal of neuro-oncology

authors： Redmond KJ,Achanta P,Grossman SA,Armour M,Reyes J,Kleinberg L,Tryggestad E,Quinones-Hinojosa A,Ford EC

更新日期：2011-09-01 00:00:00

abstract：:Pituitary adenomas produce the chemokine stromal cell-derived factor (SDF-1α/CXCL12) and its receptor, CXCR4. A recent study indicated that CXCL12 and CXCR4 are concomitantly up-regulated in hypoxia. The objective of this study was to analyze the molecular mechanism of hypoxia-mediated CXCR4 up-regulation and assess t...

journal_title：Journal of neuro-oncology

authors： Yoshida D,Koketshu K,Nomura R,Teramoto A

更新日期：2010-10-01 00:00:00

abstract：:Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) has a characteristic chimeric oncogene EWS-FLI1, which results from chromosomal translocation t (11; 22), that is believed to initiate tumorigenesis of EWS/PNET. However, the specific details of EWS/PNET oncogenesis and exact role of EWS-FLI1 remain largely un...

journal_title：Journal of neuro-oncology

authors： Yang Y,Zhang L,Wei Y,Wang H,Fukuma M,Xu H,Xiong W,Zheng J

更新日期：2008-11-01 00:00:00

abstract：:This study investigated a single institution's experience with volumetric modulated arc therapy (VMAT) directed stereotactic ablative body radiotherapy (SABR) for vertebral metastases. From 2010 to 2014, 95 lesions of spinal metastases in 73 patients were treated with SABR using VMAT. Clinical local control, pain leve...

journal_title：Journal of neuro-oncology

authors： Gestaut MM,Thawani N,Kim S,Gutti VR,Jhavar S,Deb N,Morrow A,Ward RA,Huang JH,Patel M

更新日期：2017-05-01 00:00:00

abstract：:The utility of current response criteria has not been established in anaplastic astrocytoma (AA). We retrospectively reviewed MR images for 20 patients with AA and compared RANO-based approaches to clinician impression described as follow: (1) standard RANO-based criteria met by growth of or development of new enhanci...

journal_title：Journal of neuro-oncology

authors： Kazda T,Hardie JG,Pafundi DH,Kaufmann TJ,Brinkmann DH,Laack NN

更新日期：2015-03-01 00:00:00

abstract：:A case is reported of a patient rendered quadraparetic following collapse of a cervical vertebra due to neoplastic invasion by metastatic glioblastoma multiforme. The case is discussed in light of a review of the world literature regarding the clinical incidence and significance of metastasis of glial tumors. It is re...

journal_title：Journal of neuro-oncology

authors： Chesnut RM,Abitbol JJ,Chamberlain M,Marshall LF

更新日期：1993-05-01 00:00:00

abstract：:From 1974 to 1992, 63 patients diagnosed with low-grade pure or mixed oligo-astrocytoma were seen and treated at our institution. All patients underwent CT scan pre-operatively. There were 20 female and 43 males ranging in age from 12 to 73 years (median age of 33 years). 15 patients had a stereotactic biopsy as the o...

journal_title：Journal of neuro-oncology

authors： Bahary JP,Villemure JG,Choi S,Leblanc R,Olivier A,Bertrand G,Souhami L,Tampieri D,Hazel J

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine outcomes in recurrent pediatric ependymoma. METHODS:We performed a systematic review of PubMed, Embase, Web of Science and the Cochrane Library for studies reporting on survival outcomes for pediatric patients with recurrent ependymoma. We then performed a meta-analys...

journal_title：Journal of neuro-oncology

authors： Byer L,Kline CN,Coleman C,Allen IE,Whitaker E,Mueller S

更新日期：2019-09-01 00:00:00

abstract：:The role of repeat resection in the multimodal treatment of gliomas is unclear. Repeat surgery theoretically carries a higher risk of inducing neurological deficits, which might even out any advantage of cytoreduction. We sought to determine whether the occurrence of perioperative infarction is higher for repeat surge...

journal_title：Journal of neuro-oncology

authors： Dützmann S,Geßler F,Bink A,Quick J,Franz K,Seifert V,Senft C

更新日期：2012-05-01 00:00:00

abstract：:Both cell proliferation and cell death occur simultaneously in tumor tissue, and extent of tumor growth reflects the net balance of these events. We correlated cell proliferation, spontaneous cell death, and alterations in tumor suppressor proteins with one another and with survival of patients with primary astrocytic...

journal_title：Journal of neuro-oncology

authors： Nakamizo A,Inamura T,Ikezaki K,Yoshimoto K,Inoha S,Mizoguchi M,Amano T,Fukui M

更新日期：2002-04-01 00:00:00

abstract：:Children with a brain tumor (BT) are at risk for a number of physical and cognitive problems that may lower their health-related quality of life (HRQoL). Executive functioning (EF) and intellectual ability are hypothesized to associate with HRQoL and deficits in these areas may be amenable to interventions. This study...

journal_title：Journal of neuro-oncology

authors： Netson KL,Ashford JM,Skinner T,Carty L,Wu S,Merchant TE,Conklin HM

更新日期：2016-06-01 00:00:00

abstract：:Intracranial Hodgkin's lymphoma (ICHL) in the HIV positive population is a rarely reported event with only three prior cases reported in the literature. In these prior reports, the outcome of the patients was uncertain or very poor. We report here the case of an HIV seropositive patient with an isolated intracranial r...

journal_title：Journal of neuro-oncology

authors： Ramchandar K,Verhey LH,Jha NK,Murty NK,McMillan W

更新日期：2008-08-01 00:00:00

abstract：:Gliomatosis cerebri (GC) are extensively infiltrative glial tumors classified as astrocytic tumors in the current World Health Organization (WHO) classification scheme. In investigating the tumorigenesis of GC, we reviewed 28 cases of GC immunohistochemically and carried out array-based comparative genomic hybridizati...

journal_title：Journal of neuro-oncology

authors： Min HS,Kim B,Park SH

更新日期：2008-12-01 00:00:00