Abstract:
:Population-based association studies have supported the heritability of posttraumatic stress disorder (PTSD). This study explored the influence of genetic variation in the dopamine transporter (DAT) 3' untranslated region variable number tandem repeat on the development of PTSD in preschool children exposed to Hurricane Katrina, diagnosed using a developmentally appropriate semistructured interview. A diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition , (DSM-IV; American Psychiatric Association, 1994), total symptoms, and specifically Criterion D symptoms were significantly more likely to be found in children with the 9 allele. This study replicates a previous finding in adults with PTSD. The specificity of this finding to the increased arousal symptoms of Criterion D suggests that dopamine and the DAT allele may contribute to one heritable path in a multifinality model of the development of PTSD.
journal_name
J Trauma Stressjournal_title
Journal of traumatic stressauthors
Drury SS,Theall KP,Keats BJ,Scheeringa Mdoi
10.1002/jts.20475subject
Has Abstractpub_date
2009-12-01 00:00:00pages
534-9issue
6eissn
0894-9867issn
1573-6598journal_volume
22pub_type
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