Abstract：
:Available data show that Africa, together with the Americas and western and central Europe, reported the lowest prevalence of multidrug-resistant tuberculosis (MDR-TB). However, sub-Saharan Africa has a high TB incidence and the highest human immunodeficiency virus (HIV) prevalence in the world, and because of the high number of TB cases, Africa still presents 14% of the global burden of new MDR-TB cases. Until recently, Africa and South America were deprived of second-line antituberculosis drugs, preventing the development of extensively drug-resistant TB (XDR-TB). Current efforts, introducing improved laboratory infrastructure and second-line TB treatment in resource-limited countries, need to be carried out with care to minimize the development of MDR/XDR-TB in these countries. Recent diagnostic developments now need evaluation and implementation in resource-limited areas, and delays in diagnosis also need to be addressed. Outcomes for MDR/XDR-TB have improved, but prevention of MDR/XDR-TB by early diagnosis and treatment, improvement of adherence, and proper infection control remains the mainstay for the future.
journal_name
Clin Chest Medjournal_title
Clinics in chest medicineauthors
Schaaf HS,Moll AP,Dheda Kdoi
10.1016/j.ccm.2009.08.019subject
Has Abstractpub_date
2009-12-01 00:00:00pages
667-83, vii-viiiissue
4eissn
0272-5231issn
1557-8216pii
S0272-5231(09)00095-1journal_volume
30pub_type
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