Abstract：
OBJECTIVE:Constipation is one of the most common gastrointestinal complications suspected to degrade the quality of life in diabetic patients. Mosapride citrate is a novel selective 5-HT4 receptor agonist, which enhances gastric emptying and motility in the upper gastrointestinal tract facilitating acetylcholine release from the enteric cholinergic neurons. Since the receptors of 5-HT4 have been recently found in the lower intestine including the rectum in humans, we tested if mosapride improves constipation in diabetic patients. PATIENTS AND METHODS:Diabetic patients with constipation were treated with mosapride citrate (15 mg/day, n=20) or domperidone (30 mg/day, n=12) as controls for 8 weeks. Bowel frequency was monitored and gastrointestinal symptoms were evaluated by Gastrointestinal Symptoms Rating Scale (GSRS). RESULTS:Administration of mosapride resulted in increased bowel frequency after 4 and 8 weeks of administration, while no change was seen in the control group. Mosapride increased bowel frequency in even patients with diabetic polyneuropathy. Mosapride improved reflux and constipation evaluated by GSRS. As previously reported, glycemic control also improved by mosapride in these patients. CONCLUSIONS:Administration of mosapride increased bowel frequency and ameliorated symptoms of reflux and constipation possibly stimulating the lower intestine. Given that mosapride has those beneficial aspects, it may be a useful prokinetic agent in treating diabetic patients with constipation.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Ueno N,Inui A,Satoh Ydoi
10.1016/j.diabres.2009.09.024subject
Has Abstractpub_date
2010-01-01 00:00:00pages
27-32issue
1eissn
0168-8227issn
1872-8227pii
S0168-8227(09)00416-1journal_volume
87pub_type
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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doi：10.1016/j.diabres.2003.11.008
更新日期：2004-06-01 00:00:00
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doi：10.1016/0168-8227(95)01041-b
更新日期：1995-03-01 00:00:00
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doi：10.1016/0168-8227(94)90139-2
更新日期：1994-11-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2014-12-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究
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abstract：:The purpose of this study was to investigate the effect of both a single dose and daily oral administration for 15 days of the aqueous extract of the aerial part of Chamaemelum nobile (C. nobile) at a dose of 20mg/kg body weight on blood glucose concentrations and basal insulin levels in normal and streptozotocin-indu...
journal_title：Diabetes research and clinical practice
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doi：10.1016/j.diabres.2004.07.015
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2004.06.001
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更新日期：2015-12-01 00:00:00
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更新日期：2019-09-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2009-12-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2008.06.016
更新日期：2008-10-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(01)00284-4
更新日期：2001-10-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2018.10.019
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:To explore the apoptotic role of amylin on human mesangial cell (MC). MATERIALS AND METHODS:Primarily cultured human MCs were applied and treated with fresh amylin preparation. Human MCs were identified by the morphology and immunofluorescence staining. The apoptotic cells were determined by ultrastructure c...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2007.02.018
更新日期：2007-10-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/S0168-8227(11)70024-9
更新日期：2011-08-01 00:00:00
