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IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without fasting hyperglycemia.

Abstract：

:Previous studies have established that impaired glucose tolerance (IGT) patients with fasting hyperglycemia (IGT/FH: fasting plasma glucose (FPG) level 6.1-7.0 mmol/l and 2 h PG level of 7.8-11.1 mmol/l) exhibit higher insulin resistance than those with isolated IGT (FPG level <6.1 mmol/l and 2 h PG level of 7.8-11.1 mmol/l), but the association with microalbuminuria has not been determined. Here, we evaluate the prevalence of microalbuminuria in non-diabetic Japanese males 20-70 years of age. The subjects were classified into four groups based on the results of OGTT: normal glucose tolerance (NGT: n=71), impaired fasting glucose (IFG: n=24), isolated IGT (n=36), and IGT/FH (n=23). A urinary albumin-to-creatinine ratio (ACR) from 30 to 300 microg/mg creatinine was counted as microalbuminuria. The prevalence of microalbuminuria was higher in subjects with IGT/FH than in subjects with isolated IGT (26% versus 14%). Logistic regression analysis showed microalbuminuria to be more significantly associated with IGT/FH (OR=3.82, 95% CI 1.09-13.36) than with isolated IGT (OR=1.75, 95% CI 0.50-6.17). While insulin resistance (HOMA-IR) in isolated IGT was not significantly different from that in NGT, insulin resistance in IGT/FH was significantly higher (P<0.01). Regression analysis of ACR in IGT showed a significant correlation with insulin resistance (P=0.012). Accordingly, microalbuminuria is more strongly associated with IGT/FH than with isolated IGT, most likely due to the higher insulin resistance.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Suzuki H,Fukushima M,Usami M,Ikeda M,Taniguchi A,Nakai Y,Matsuura T,Yasuda K,Hosokawa M,Seino Y,Yamada Y

doi

10.1016/j.diabres.2003.11.008

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

213-9

issue

3

eissn

0168-8227

issn

1872-8227

pii

S0168822703002985

journal_volume

64

pub_type

杂志文章

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