The use of antithrombotic agents in microvascular surgery.

Abstract:

:Despite increasing advances in microvascular free tissue transfer, flap failures, most commonly resulting from thrombosis at the anastomotic vascular site, remain a significant concern. Although several experimental and clinical studies have been carried out, no consensus has been reached so far on the efficacy, dosage and timing of anticoagulant agents available for the prevention and treatment of thrombosis in microvascular surgery. Inhibition of fibrin formation and platelet function or the use of thrombolytic agents is a common approach in the antithrombotic management. However, some agents exhibit serious side effects and all of them carry the risk of bleedings. The current literature on the use of antithrombotic agents, targeting at clinical trials in microvascular surgery, is therefore reviewed, to provide an informative basis for recommendations for an appropriate pharmacological approach.

authors

Stephan B,Schenk JF,Nemeh A,Pindur G

doi

10.3233/CH-2009-1220

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

51-6

issue

1-2

eissn

1386-0291

issn

1875-8622

pii

M684176565KW48XL

journal_volume

43

pub_type

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