Biochemical relevance between oxidative/carbonyl stress and elevated viscosity of erythrocyte suspensions.

Abstract:

:The effects of various aldehydes such as secondary products of peroxidized lipids and other aldehydes on rheological parameters and their relation with aging process were studied. Malondialdehyde (MDA) in different concentrations can increase significantly viscosity and plastic viscosity of erythrocytes suspended in plasma and HEPES buffer solution. Simultaneously, oxidation induced by Fe2+ can also enhance the viscosity of erythrocyte suspensions. All of these data suggest that MDA as one of the most studied unsaturated carbonyl products of lipid peroxidation leading to protein crosslinking may carry important information in understanding carbonyl stress-related rheological change in acute as well as chronic diseases and aging.

authors

Liu X,Qin W,Yin D

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

149-56

issue

2

eissn

1386-0291

issn

1875-8622

journal_volume

31

pub_type

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