Abstract:
:Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thrombotic processes. In summary, a mechanistic correlation between the gut microbiome, TMAO and cardiovascular diseases becomes obvious and emphasizes to the significance of the intestinal microbiome.
journal_name
Clin Hemorheol Microcircjournal_title
Clinical hemorheology and microcirculationauthors
Krüger-Genge A,Jung F,Hufert F,Jung EM,Küpper JH,Storsberg Jdoi
10.3233/CH-209206subject
Has Abstractpub_date
2020-01-01 00:00:00pages
309-316issue
2eissn
1386-0291issn
1875-8622pii
CH209206journal_volume
76pub_type
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journal_title:Clinical hemorheology and microcirculation
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journal_title:Clinical hemorheology and microcirculation
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journal_title:Clinical hemorheology and microcirculation
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journal_title:Clinical hemorheology and microcirculation
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