Effects of gut microbial metabolite trimethylamine N-oxide (TMAO) on platelets and endothelial cells.

Abstract:

:Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thrombotic processes. In summary, a mechanistic correlation between the gut microbiome, TMAO and cardiovascular diseases becomes obvious and emphasizes to the significance of the intestinal microbiome.

authors

Krüger-Genge A,Jung F,Hufert F,Jung EM,Küpper JH,Storsberg J

doi

10.3233/CH-209206

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

309-316

issue

2

eissn

1386-0291

issn

1875-8622

pii

CH209206

journal_volume

76

pub_type

杂志文章
  • Erythrocyte osmotic fragility increases with serum advanced glycated end products in cigarette smokers.

    abstract:BACKGROUND:This study examines the relationship between circulating advanced glycated end products (AGEs) level and erythrocyte osmotic fragility in smokers. METHODS:Forty-eight smokers (aged 45 ± 5 years) and fifty healthy nonsmokers (aged 42 ± 6 years) were selected in this study. All subjects were analysed accordin...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-131801

    authors: Li R,Chen X

    更新日期:2014-01-01 00:00:00

  • Challenges for microcirculation research in developing countries.

    abstract:BACKGROUND:Microvascular dysfunction is a main contributor to morbidity and mortality worldwide. Sophisticated technical tools (e.g. miniaturized hardware, automated software), along with skilled personnel are the prerequisite for quantitative observations of the microvasculature. OBJECTIVE:This review aimed to get an...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,评审

    doi:10.3233/CH-190611

    authors: Islam S,Ahmed N,Rivu SF,Khalil M,Tanjia N,Lehmann C

    更新日期:2019-01-01 00:00:00

  • Shear resistance of human umbilical endothelial cells on different materials covered with or without extracellular matrix: controlled in-vitro study.

    abstract::A variety of medical grade polymeric materials are used in tissue engineering and biomedical technology. Dense non-porous polymeric foils were used as substrates for endothelial cell layers. Half a the test samples (polymers and control materials) were seeded with bovine corneal endothelial cells (BCEC) which more or ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2009-1230

    authors: Hoepken S,Fuhrmann R,Jung F,Franke RP

    更新日期:2009-01-01 00:00:00

  • Modulation of RAGE expression influences the adhesion of red blood cells from diabetic patients.

    abstract::Atherothrombotic complications are frequent in patients with type 2 diabetes. Red blood cells (RBC) from diabetic patients exhibited an increased adhesion which correlated to the extent of vascular complications. In the present study we have investigated the adhesive interactions of RBCs with endothelium, using flow-b...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Wautier MP,Khodabandehlou T,Le Dévéhat C,Wautier JL

    更新日期:2006-01-01 00:00:00

  • Parametric imaging with contrast-enhanced ultrasound: usefulness for characterization of dynamic effects of microvascularization for hepatocellular carcinoma and focal nodular hyperplasia.

    abstract:OBJECTIVE:To evaluate whether parametric imaging with contrast-enhanced ultrasound (CEUS) is equal to experienced radiologists after review of CEUS in differentiating hepatocellular carcinoma (HCC) from focal nodular hyperplasia (FNH). METHODS:An image processing software was used to quantitatively analyze the CEUS cl...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-121652

    authors: Zheng SG,Xu HX,Liu LN,Wang Y,Zhang YF,Guo LH,Liu C,Xu JM,Sun LP,Wu J

    更新日期:2013-01-01 00:00:00

  • Micro-vascular medicine and proteomics.

    abstract::A new technique is sweeping the world, and changing the course of human work and life. It is impacting upon models, methods and the development of medical research. In the development of this new technique, a huge quantity of experimental research and clinical practice has proved that many human diseases have a close ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,评审

    doi:

    authors: Zhang HG,Xiu RJ

    更新日期:2003-01-01 00:00:00

  • Effects of haemoglobin levels on the sublingual microcirculation in pregnant women.

    abstract::Anemia in pregnant women is associated with increased maternal and perinatal mortality and represents an important economic burden in many developing countries. Our goal was to evaluate the impact of anemia on the capillary network during pregnancy. Therefore, we compared microcirculatory parameters of anemic pregnant...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-162064

    authors: Sharawy N,Hussein A,Hossny O,Refaa A,Saka A,Mukhtar A,Whynot S,George R,Lehmann C

    更新日期:2016-11-25 00:00:00

  • Impaired blood rheology by remnant-like lipoprotein particles: studies in patients with fatty liver disease.

    abstract::Fatty liver disease (FLD) characterised by a high plasma levels of lipoproteins and remnant-like lipoproteins (RLP) is a risk factor for impaired microvascular blood flow, endothelial cell dysfunction and atherosclerosis. Using an immunoseparation technique with a gel mixture containing human monoclonal antibodies to ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Kurihara T,Deguchi S,Kato J,Furakawa M,Tsuchiya M,Akimoto M,Ishiguro H,Hashimoto H,Niimi A,Maeda A,Shigemoto M,Yamashita K,Kawakami A,Umemura K,Nakashima M,Nakano T,Saniabadi AR

    更新日期:2001-01-01 00:00:00

  • Skin microcirculation in healthy term newborn infants--assessment of morphology, perfusion and oxygenation.

    abstract:UNLABELLED:Despite microcirculation's fundamental role, assessments of its function are limited. We explored the applicability of Computer Assisted Video Microscope (CAVM), Laser Doppler Perfusion Measurements (LDPM) and Diffuse Reflectance Spectroscopy (DRS) to study skin microvascular morphology, perfusion and oxygen...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-131764

    authors: Fredly S,Fugelseth D,Wester T,Häggblad E,Kvernebo K

    更新日期:2015-01-01 00:00:00

  • A new simple cone-plate viscometer for hemorheology.

    abstract::The aim of this work was to evaluate a new automatic cone-plate viscometer (LBY-N6, PRECIL, Beijing, China) which was designed for clinical measurements of blood and plasma viscosities. Standard calibrating oils of viscosity varying from 1.85 to 20.5 mPas (conforming to ASTM Standard) were used to test the precision a...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Wang X,Liao FL,Stoltz JF

    更新日期:1998-09-01 00:00:00

  • Exposure of human neutrophils to oxygen radicals causes loss of deformability, lipid peroxidation, protein degradation, respiratory burst activation and loss of migration.

    abstract::The effects of oxygen radical generating system of H(2)O(2) on neutrophil deformability, lipid peroxidation, protein degradation, chemotaxis, random migration and activation were studied in the presence and absence of selected anti-oxidants such as vitamin E and carbon monoxide. Hydrogen peroxide caused a significant ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Abu-Khader AA,Bilto YY

    更新日期:2002-01-01 00:00:00

  • The influence of cryoglobulins on the temperature-dependent erythrocyte aggregation in vitro by backscattering nephelometry.

    abstract::Nephelometry technique was used to register the alterations of the scattering signal from a whole blood sample due to erythrocyte aggregates in stasis and under controlled shear stress. The measured parameters were: the characteristic times of linear and three-dimensional aggregates formation, and the strength of aggr...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Konstantinova NA,Matveeva NA,Sirko IV,Firsov NN

    更新日期:2004-01-01 00:00:00

  • Ultrasound elastography for the detection of capsular fibrosis in breast implants: First results.

    abstract:BACKGROUND:Capsular contractures around breast implants usually develop leading to pain and aesthetically inadequate results and ultimately often requires the replacement of the implants. Textured silicone implants are the most commonly placed implant, but polyurethane-coated implants are increasingly being used in an ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-200875

    authors: Jung E,Hösl V,von Fraunberg S,Jung F,Prantl L

    更新日期:2020-09-08 00:00:00

  • Acute responses of platelet count and ADP-induced platelet aggregation to different high intensity interval exercise modes.

    abstract:BACKGROUND:Platelet activation is associated with abdominal obesity and exercise training is an important modulator of body weight. OBJECTIVE:We investigated the effects of two high intensity interval exercise (HIIE) protocols of different intensity and duration on platelet indices and platelet aggregation in overweig...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-200848

    authors: Ahmadizad S,Rahmani H,Khosravi N,Falakdin Z,Connes P,Daraei A

    更新日期:2020-01-01 00:00:00

  • Effects of dance movement therapy on the rheological properties of blood in elderly women.

    abstract:OBJECTIVE:The aim of this study was to analyse the effects of dance movement therapy exercises (DMT) on the rheological properties of blood in elderly women. METHODS:The study encompassed group of women (mean aged: 67 years), who were subjected to three-month dance movement therapy programme (n = 20). Blood samples fr...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-180470

    authors: Filar-Mierzwa K,Marchewka A,Dąbrowski Z,Bac A,Marchewka J

    更新日期:2019-01-01 00:00:00

  • Hemorheology and circulation.

    abstract::The main functions of the blood are the transport, and delivery of oxygen and nutrients, removal of carbon dioxide and waste products of metabolism, distribution of heat and signals of immune system. They are provided by circulation due to the driving force of the heart. Circulation of the blood depends on its rheolog...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,评审

    doi:10.3233/CH-2009-1192

    authors: Marossy A,Svorc P,Kron I,Gresová S

    更新日期:2009-01-01 00:00:00

  • Absent post-ischemic increase of blood flowmotion in the cutaneous microcirculation of healthy chronic cigarette smokers.

    abstract::The aim of the study was to investigate whether chronic cigarette smoke habit is associated with changes of laser Doppler (LD) skin blood flowmotion (SBF). We performed spectral analysis of skin forearm LD signal detected by a LD flowmetry (Periflux PF4, Perimed, Sweden) before and during forearm post-ischemic hyperae...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Rossi M,Carpi A,Di Maria C,Galetta F,Santoro G

    更新日期:2007-01-01 00:00:00

  • Evaluation of multimodality imaging using image fusion with ultrasound tissue elasticity imaging in an experimental animal model.

    abstract:PURPOSE:To evaluate the ultrasound tissue elasticity imaging by comparison to multimodality imaging using image fusion with Magnetic Resonance Imaging (MRI) and conventional grey scale imaging with additional elasticity-ultrasound in an experimental small-animal-squamous-cell carcinoma-model for the assessment of tissu...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-141821

    authors: Paprottka PM,Zengel P,Cyran CC,Ingrisch M,Nikolaou K,Reiser MF,Clevert DA

    更新日期:2014-01-01 00:00:00

  • Attenuating effect of Myakuryu on mesenteric microcirculatory disorders induced by ischemia and reperfusion.

    abstract::Myakuryu (MR) is a newly developed herbal medicine composing Crataegue oinnatifida bge (COB), Panax notoginseng (PN) and Ginkyo biloba (GB). To examine the effectiveness of MR, we investigated its effects on rat mesenteric microcirculatory injury induced by ischemia/reperfusion (I/R). The mesenteric microcirculation o...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Han JY,Horie Y,Li D,Akiba Y,Nagata H,Miura S,Oda M,Ishii H,Hibi T

    更新日期:2006-01-01 00:00:00

  • Numerical investigation on red blood cell dynamics in microflow: Effect of cell deformability.

    abstract::The radial dispersion of red blood cells (RBCs) near the vessel wall can significantly affect the transport dynamics in small vessels. The radial dispersion of RBCs is mainly caused by collisions between RBCs and this can be enhanced by aggregation. The objective of this study is to numerically investigate on the effe...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-16128

    authors: Ju M,Leo HL,Kim S

    更新日期:2017-01-01 00:00:00

  • Effects of cigarette smoking on hemorheologic parameters, plasma osmolality and lung function.

    abstract:BACKGROUND:Cigarette smoking deteriorates human health via vascular disorders, cancer and especially respiratory diseases. The aim of this study is to investigate effects of cigarette smoking on hemorheologic parameters, plasma osmolality and lung function in individuals without diagnosis of chronic obstructive pulmona...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-152018

    authors: Ergun DD,Karis D,Alkan FA,Cakmak G,Yenigun M,Ercan M

    更新日期:2016-10-05 00:00:00

  • Astroglial swelling for removed rat brain enlargement incubated in deoxygenated mock cerebrospinal fluid.

    abstract::The source and target of edema fluid for ischemic brain swelling clinically often observed in "malignant infarction" was examined in ex vivo. Wister rat brain hemispheres were removed and incubated air-tightly in a deoxygenated artificial cerebrospinal fluid at 37 degrees for 30 min. Ionic movement into the brain tiss...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Osada T,Tomita M,Tanahashi N,Takeda H,Nagai T,Suzuki N

    更新日期:2006-01-01 00:00:00

  • Susceptibility of erythrocytes from non-insulin-dependent diabetes mellitus and hemodialysis patients, cigarette smokers and normal subjects to in vitro oxidative stress and loss of deformability.

    abstract::Incubation of normal erythrocytes with 10 mM H2O2 has caused a loss of deformability. This loss of deformability was correlated with the extent of malonyldialdehyde, MDA (an indicator of lipid peroxidation) and alanine production (an indicator of protein degradation). The susceptibility of erythrocytes from 21 non-ins...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Srour MA,Bilto YY,Juma M

    更新日期:2000-01-01 00:00:00

  • The influence of a multifunctional, polymeric biomaterial on the concentration of acute phase proteins in an animal model.

    abstract::The concentrations of the acute phase proteins alpha1-Acid Glycoprotein (AAG) and haptoglobin were determined in Sprague-Dawley-rats after implantation of a novel biodegradable multifunctional polymeric biomaterial for the reconstruction of a gastric wall defect (polymer group; n=42). For comparison, the concentration...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Rickert D,Scheithauer MO,Coskun S,Kelch S,Lendlein A,Franke RP

    更新日期:2007-01-01 00:00:00

  • Radiographic contrast media alterate the localization of actin/band4.9 in the membrane cytoskeleton of human erythrocytes.

    abstract::Different radiographic contrast media (RCM) were shown to induce morphological changes of blood cells (e.g. erythrocytes or thrombocytes) and endothelial cells. The echinocytic shape change of erythrocytes, particularly, affords alterations of the membrane cytoskeleton. The cytoskeleton plays a crucial role for the sh...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-141894

    authors: Franke RP,Scharnweber T,Fuhrmann R,Mrowietz C,Wenzel F,Krüger A,Jung F

    更新日期:2014-01-01 00:00:00

  • Evaluation of human mesenchymal stem cell senescence, differentiation and secretion behavior cultured on polycarbonate cell culture inserts.

    abstract::Polycarbonate (PC) substrate is well suited for culturing human mesenchymal stem cells (MSCs) with high proliferation rate, low cell apoptosis rate and negligible cytotoxic effects. However, little is known about the influence of PC on MSC activity including senescence, differentiation and secretion. In this study, th...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-189322

    authors: Zou J,Wang W,Kratz K,Xu X,Nie Y,Ma N,Lendlein A

    更新日期:2018-01-01 00:00:00

  • Chronic pharmacological preconditioning against ischemia.

    abstract::Despite decades of research and thousands of experimental publications, acute preconditioning strategies have yet to be implemented in clinical practice. While some have attributed this to a failure of the experimental studies to mimic the clinical environment, others have suggested that acute preconditioning strategi...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,评审

    doi:10.3233/CH-2011-1479

    authors: Luca MC,Liuni A,Muxel S,Münzel T,Forconi S,Gori T,Parker JD

    更新日期:2011-01-01 00:00:00

  • Modulating human mesenchymal stem cells using poly(n-butyl acrylate) networks in vitro with elasticity matching human arteries.

    abstract::Non-swelling hydrophobic poly(n-butyl acrylate) network (cPnBA) is a candidate material for synthetic vascular grafts owing to its low toxicity and tailorable mechanical properties. Mesenchymal stem cells (MSCs) are an attractive cell type for accelerating endothelialization because of their superior anti-thrombosis a...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-189418

    authors: Wang W,Xu X,Li Z,Kratz K,Ma N,Lendlein A

    更新日期:2019-01-01 00:00:00

  • Increased dense erythrocytes in flame-burned patients.

    abstract:OBJECTIVE:We have studied dense erythrocytes separated on Arabinogalactan (Stractan) ultracentrifuged gradients in flame-burned patients and in normal individuals. In each case, the percentage of erythrocytes in the densest layers was increased when compared to age and sex matched controls. METHODS AND RESULTS:Using a...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2012-1556

    authors: Saavedra AP,Warth JA,Burke JF,Norton KJ,Gelfand JA

    更新日期:2013-01-01 00:00:00

  • Effect of extracts of poly(ether imide) microparticles on cytotoxicity, ROS generation and proinflammatory effects on human monocytic (THP-1) cells.

    abstract::Current haemodialysis techniques are not capable to remove efficiently low molecular weight hydrophobic uremic toxins from the blood of patients suffering from chronic renal failure. With respect to the hydrophobic characteristics and the high level of protein binding of these uremic toxins, hydrophobic adsorber mater...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-152027

    authors: Kumar RK,Basu S,Lemke HD,Jankowski J,Kratz K,Lendlein A,Tetali SD

    更新日期:2016-01-01 00:00:00