当前位置： SCI文献检索 > CLINICAL HEMORHEOLOGY AND MICROCIRCULATION期刊下所有文献 > Influence of nanoporous poly(ether imide) particle extracts on human aortic endothelial cells (HAECs).

Influence of nanoporous poly(ether imide) particle extracts on human aortic endothelial cells (HAECs).

Abstract：

:Accumulated uremic toxins like indoxyl sulphate, hippuric acid and p-cresyl sulphates in renal failure patients stimulate proinflammatory effects, and consequently kidney and cardiovascular diseases. Low clearance rate of these uremic toxins from the blood of uremic patients by conventional techniques like hemodialysis is due to their strong covalent albumin binding (greater than 95%) and hydrophobic nature, which led to alternatives like usage of hydrophobic adsorber's in removing these toxins from the plasma of kidney patients. Polymers like polyethylene, polyurethane, polymethylmethacrylate, cellophane and polytetrafluoroethylene were already in use as substitutes for metal devices as dialysis membranes. Among new synthetic polymers, one such ideal adsorber material are highly porous microparticles of poly(ether imide) (PEI) with diameters in the range from 50-180μm and a porosity around 88±2% prepared by a spraying and coagulation process.It is essential to make sure that these synthetic polymers should not evoke any inflammatory or apoptotic response during dialysis. Therefore in our study we evaluated in vitro effect of PEI microparticle extracts in human aortic endothelial cells (HEACs) concerning toxicity, inflammation and apoptosis. No cell toxicity was observed when HAECs were treated with PEI extracts and inflammatory/apoptotic markers were not upregulated in presence of PEI extracts. Our results ensure biocompatibility of PEI particles and further hemocompatibility of particles will be tested.

journal_name

Clin Hemorheol Microcirc

journal_title

Clinical hemorheology and microcirculation

authors

Kumar RK,Basu S,Lemke HD,Jankowski J,Kratz K,Lendlein A,Tetali SD

doi

10.3233/CH-168046

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

931-940

issue

4

eissn

1386-0291

issn

1875-8622

pii

CH168046

journal_volume

64

pub_type

杂志文章

相关文献

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION文献大全
  • Red blood cell-deformability measurement: review of techniques.

    abstract：:Cell-deformability characterization involves general measurement of highly complex relationships between cell biology and physical forces to which the cell is subjected. The review takes account of the modern technical solutions simulating the action of the force applied to the red blood cell in macro- and microcircul...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章,评审

    doi：10.3233/CH-2009-1187

    authors： Musielak M

    更新日期：2009-01-01 00:00:00

  • Microcirculation and tissue metabolism in peripheral arterial disease.

    abstract：:It is now clear that different pathophysiologic mechanisms have a profound influence on the extent of the functional impairment in intermittent claudication. In particular, metabolic derangements, including impaired oxygen delivery and/or extraction, reduced nitric oxide synthesis, reduced glucose oxidation, accumulat...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章,评审

    doi：

    authors： Brevetti G,Corrado S,Martone VD,Di Donato A,Silvestro A,Vanni L

    更新日期：1999-01-01 00:00:00

  • Effects of haemoglobin levels on the sublingual microcirculation in pregnant women.

    abstract：:Anemia in pregnant women is associated with increased maternal and perinatal mortality and represents an important economic burden in many developing countries. Our goal was to evaluate the impact of anemia on the capillary network during pregnancy. Therefore, we compared microcirculatory parameters of anemic pregnant...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-162064

    authors： Sharawy N,Hussein A,Hossny O,Refaa A,Saka A,Mukhtar A,Whynot S,George R,Lehmann C

    更新日期：2016-11-25 00:00:00

  • Doppler ultrasonography and contrast-enhanced ultrasonography to evaluate liver allograft discard: A pilot prospective study.

    abstract：BACKGROUND:Broad hemodynamic changes, is believed to have a profoundly damaging effect on donor livers after brain death (DBD) or cardiac death (DCD). It remains unclear whether Doppler ultrasonography (DUS) and contrast-enhanced ultrasonography (CEUS), the imaging modalities to evaluate perfusion, could provide more i...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-200950

    authors： Zhang HJ,Zheng BW,Gu SJ,Wu T,Wu LL,Lian YF,Tong G,Yi SH,Ren J

    更新日期：2020-09-08 00:00:00

  • Haemorheological profile in congenital afibrinogenemia and in congenital dysfibrinogenemia: A clinical case report.

    abstract：:Although the inherited quantitative and qualitative disorders of fibrinogen are rare, in the course of time patients may develop complications including episodes of arterial and venous thrombosis. It can be useful to complete the laboratory assessment of these clinical conditions with the evaluation of the haemorheolo...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-180542

    authors： Caimi G,Raso S,Napolitano M,Hopps E,Lo Presti R,Siragusa S

    更新日期：2019-01-01 00:00:00

  • L-arginine as dietary supplement for improving microvascular function.

    abstract：BACKGROUND:Reduced availability of nitric oxide leads to dysfunction of endothelium which plays an important role in the development of cardiovascular diseases. OBJECTIVE:The aim of the present study was to determine whether the dietary supplement L-arginine improves the endothelial function of microvessels by increas...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-16159

    authors： Melik Z,Zaletel P,Virtic T,Cankar K

    更新日期：2017-01-01 00:00:00

  • Current approaches to non-invasive optical oximetry.

    abstract：:The optical oxymetry methods based on light transmission or diffuse reflectance of living tissues are discussed. The experimental techniques now under test are highlighted. ...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章,评审

    doi：

    authors： Lugarà PM

    更新日期：1999-01-01 00:00:00

  • Timing of clopidogrel loading dose on peripheral blood endothelial progenitor cells, SDF-1α and neointimal hyperplasia in carotid stenting.

    abstract：BACKGROUND:Carotid stenting stimulates intimal proliferation through platelet and stem cell activation. OBJECTIVE:The aim of this study is to evaluate whether the administration before or after carotid stenting of clopidogrel loading dose may play a role on circulating endothelial progenitor cells, stromal cell-derive...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章,随机对照试验

    doi：10.3233/CH-180429

    authors： Di Stolfo G,Mastroianno S,Ruggieri M,Fontana A,Marinucci R,Copetti M,Minervini MM,Savino L,Mastroianno M,Savino M,Pacilli MA,Di Mauro L,Potenza DR,Cascavilla N,Paroni G,Russo A

    更新日期：2019-01-01 00:00:00

  • The effects of Chinese herb Angelica in focal cerebral ischemia injury in the rat.

    abstract：:This experiment was designed to study the therapeutic mechanisms of Angelica on the focal cerebral ischemia injury of the rat. The ischemic area was determined by TTC stain. And terminal deoxynucleotidyl transferase (TDT) mediated DUTP-biotin nick end labeling (TUNEL) method was applied to detect neuronal apoptosis. T...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Yang JW,Ouyang JP,Liao WJ,Tian J,Liu YM,Wei L,Wang BH,Li K

    更新日期：2005-01-01 00:00:00

  • Image fusion in the management of thermal tumor ablation of the liver.

    abstract：PURPOSE:The purpose of this study was to evaluate whether image fusion with contrast enhanced ultrasound (CEUS) and CT is effective in the pre-, intra- and post-interventional management of liver lesions during microwave or radiofrequency ablation. METHODS AND MATERIALS:Fifteen patients with a single hepatocellular ca...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-2012-1598

    authors： Clevert DA,Paprottka PM,Helck A,Reiser M,Trumm CG

    更新日期：2012-01-01 00:00:00

  • Conventional US combined with acoustic radiation force impulse (ARFI) elastography for prediction of triple-negative breast cancer and the risk of lymphatic metastasis.

    abstract：PURPOSE:To evaluate the combination of conventional ultrasound (US) and acoustic radiation force impulse (ARFI) elastography in predicting triple-negative breast cancer and the likelihood of lymphatic metastasis. MATERIALS AND METHODS:A total of 178 women presenting from May 2013 to September 2015 with pathologically ...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-16196

    authors： Pu H,Zhao LX,Yao MH,Xu G,Liu H,Xu HX,Wu R

    更新日期：2017-01-01 00:00:00

  • Effects of salvianolic acids on erythrocyte deformability in oleic acid induced acute lung injury in rabbits.

    abstract：:The present study was to investigate the protective effects of salvianolic acids (SA) on deformability of red blood cells (RBCs) and its mechanism during the development of acute lung injury (ALI) induced by oleic acid (OA) in rabbits. 32 rabbits were randomized into four groups, normal control group, OA-treated group...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Xing JJ,Chen X,Tu PF,Jiang Y,Zhao JY

    更新日期：2006-01-01 00:00:00

  • The role of erythrocytapheresis in secondary erythrocytosis therapy.

    abstract：:In chronic respiratory insufficiency secondary erythrocytosis (SPC), causing pulmonary hypertension and dx ventricular insufficiency, is often noticed. An alternative therapy to phlebotomy for SPC is isovolemic large volume erythrocytapheresis performed with cell separator (CSE) in order to quickly remove a large volu...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Pollari G,Antonini V,Izzo A,Moreschini G,Serraino M,Tonelli V,D'Angiolino A,Migliaccio M

    更新日期：1999-01-01 00:00:00

  • Formulation of drug-loaded oligodepsipeptide particles with submicron size.

    abstract：:The size of particulate carriers is key to their transport and distribution in biological systems, and needs to be tailored in the higher submicron range to enable follicular uptake for dermal treatment. Oligodepsipeptides are promising nanoparticlulate carrier systems as they can be designed to exhibit enhanced inter...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-200977

    authors： Brunacci N,Wischke C,Naolou T,Patzelt A,Lademann J,Neffe AT,Lendlein A

    更新日期：2020-11-11 00:00:00

  • Astroglial swelling for removed rat brain enlargement incubated in deoxygenated mock cerebrospinal fluid.

    abstract：:The source and target of edema fluid for ischemic brain swelling clinically often observed in "malignant infarction" was examined in ex vivo. Wister rat brain hemispheres were removed and incubated air-tightly in a deoxygenated artificial cerebrospinal fluid at 37 degrees for 30 min. Ionic movement into the brain tiss...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Osada T,Tomita M,Tanahashi N,Takeda H,Nagai T,Suzuki N

    更新日期：2006-01-01 00:00:00

  • Modulating human mesenchymal stem cells using poly(n-butyl acrylate) networks in vitro with elasticity matching human arteries.

    abstract：:Non-swelling hydrophobic poly(n-butyl acrylate) network (cPnBA) is a candidate material for synthetic vascular grafts owing to its low toxicity and tailorable mechanical properties. Mesenchymal stem cells (MSCs) are an attractive cell type for accelerating endothelialization because of their superior anti-thrombosis a...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-189418

    authors： Wang W,Xu X,Li Z,Kratz K,Ma N,Lendlein A

    更新日期：2019-01-01 00:00:00

  • Value of high-resolution contrast-enhanced ultrasound in detection and characterisation of endoleaks after EVAR.

    abstract：PURPOSE:To compare the value of high-resolution contrast-enhanced ultrasound in the detection and characterisation of endoleaks after EVAR. MATERIAL AND METHODS:In this retrospective study, a cohort of 80 patients underwent both standard examination using a curved array 5 MHz transducer and a second examination using ...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-141896

    authors： Zimmermann H,D'Anastasi M,Rjosk-Dendorfer D,Helck A,Meimarakis G,Reiser M,Clevert DA

    更新日期：2014-01-01 00:00:00

  • Phototherapy decreases red blood cell deformability in patients with psoriasis.

    abstract：BACKGROUND:Alternations in erythrocyte deformability (ED), namley, the ability of erythrocytes to change shape under flow in the microcirculation, can contribute to cardiovascular diseases. Psoriasis, a systemic inflammatory skin disorder, is associated with an increased cardiovascular risk. The effect of psoriasis and...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-180424

    authors： Biran R,Hadayer N,Ramot Y,Zlotogorski A,Yedgar S,Barshtein G

    更新日期：2019-01-01 00:00:00

  • First results of endocavity evaluation of the microvascularization of malignant prostate tumors using contrast enhanced ultrasound (CEUS) including perfusion analysis: first results.

    abstract：AIM:Detection of prostate cancer lesions using transrectal contrast enhanced ultrasound (CEUS) of the prostate utilizing quantitative perfusion analysis. METHOD:20 patients (mean age 63 years, 47-71) with biopsy proven prostate cancer underwent transrectal ultrasound (TRUS) prior to radical prostatectomy by 2 experien...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-2012-1594

    authors： Jung EM,Wiggermann P,Greis C,Eder F,Ehrich J,Jung W,Schreyer AG,Stroszczynski C,Ganzer R

    更新日期：2012-01-01 00:00:00

  • Importance of methodological standardization for the ektacytometric measures of red blood cell deformability in sickle cell anemia.

    abstract：:Red blood cell (RBC) deformability is severely decreased in patients with sickle cell anemia (SCA), which plays a role in the pathophysiology of the disease. However, investigation of RBC deformability from SCA patients demands careful methodological considerations. We assessed RBC deformability by ektacytometry (LORR...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-151979

    authors： Renoux C,Parrow N,Faes C,Joly P,Hardeman M,Tisdale J,Levine M,Garnier N,Bertrand Y,Kebaili K,Cuzzubbo D,Cannas G,Martin C,Connes P

    更新日期：2016-01-01 00:00:00

  • Effects of fluid shear stress on expression of proto-oncogenes c-fos and c-myc in cultured human umbilical vein endothelial cells.

    abstract：:The objective of our research was to reveal the effects of different shear stresses on the expression of proto-oncogenes c-fos and c-myc in cultured human umbilical vein endothelial cells (HUVEC). A parallel plate flow chamber was used to control the value and duration of shear stress (SS), and the expression of c-fos...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Li C,Zeng Y,Hu J,Yu H

    更新日期：2002-01-01 00:00:00

  • Blood rheological abnormalities in sickle cell anemia.

    abstract：:This review focuses on the contribution of abnormal blood rheology in the pathophysiology of sickle cell anemia (SCA). SCA is characterized by a reduction of red blood cell (RBC) deformability but this reduction is very heterogeneous among patients. Recent works have shown that patients with the lowest RBC deformabili...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-189005

    authors： Connes P,Renoux C,Romana M,Abkarian M,Joly P,Martin C,Hardy-Dessources MD,Ballas SK

    更新日期：2018-01-01 00:00:00

  • Biochemical relevance between oxidative/carbonyl stress and elevated viscosity of erythrocyte suspensions.

    abstract：:The effects of various aldehydes such as secondary products of peroxidized lipids and other aldehydes on rheological parameters and their relation with aging process were studied. Malondialdehyde (MDA) in different concentrations can increase significantly viscosity and plastic viscosity of erythrocytes suspended in p...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Liu X,Qin W,Yin D

    更新日期：2004-01-01 00:00:00

  • Effect of a modified fibrate (Biniwas Retard) on hemorheological alterations in hyperlipemic patients.

    abstract：:The effect of a binifibrate (Biniwas Retard, Wasserman) on the plasma lipids and hemorheological profile of 30 primary hyperlipemic patients was studied. Our results indicate that the patients under study had evident rheological alterations as well as the expected lipid alterations. Treatment with Biniwas (2 x 550 mg/...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Labios M,Martínez M,Vayá A,Gabriel F,Guiral V,Aznar J

    更新日期：1999-01-01 00:00:00

  • Haematological, biochemical and inflammatory parameters in inactive Behçet's disease. Its association with red blood cell distribution width.

    abstract：:Red blood cell distribution width (RDW) has been shown to be associated with disease activity in several inflammatory disorders. However only one study to show this has been conducted in patients with Behçet's disease (BD). The aim of the present study was to analyse the association of RDW with BD and its main complic...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-131744

    authors： Vayá A,Rivera L,Todolí J,Hernandez JL,Laiz B,Ricart JM

    更新日期：2014-01-01 00:00:00

  • Susceptibility of erythrocytes from non-insulin-dependent diabetes mellitus and hemodialysis patients, cigarette smokers and normal subjects to in vitro oxidative stress and loss of deformability.

    abstract：:Incubation of normal erythrocytes with 10 mM H2O2 has caused a loss of deformability. This loss of deformability was correlated with the extent of malonyldialdehyde, MDA (an indicator of lipid peroxidation) and alanine production (an indicator of protein degradation). The susceptibility of erythrocytes from 21 non-ins...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Srour MA,Bilto YY,Juma M

    更新日期：2000-01-01 00:00:00

  • Use of contrast-enhanced ultrasound to monitor rabbit renal ischemia-reperfusion injury and correlations between time-intensity curve parameters and renal ICAM-1 expression.

    abstract：BACKGROUND:Renal ischemia-reperfusion injury (IRI) is common in renal transplantation, shock, and nephrolithotomy. OBJECTIVE:To quantitatively assess rabbit renal IRI with contrast-enhanced ultrasound (CEUS) and investigate associations between renal cortical time-intensity curve (TIC) parameters and intracellular adh...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-131768

    authors： Li M,Luo Z,Chen X,Xuan J,Ye F,Liu H,Chen K

    更新日期：2015-01-01 00:00:00

  • IL-17 predicts the effect of TACE combined with apatinib in hepatocellular carcinoma.

    abstract：OBJECTIVE:IL-17 is considered to be a cancer-promoting gene in hepatocellular carcinoma (HCC). Here, we explored the effect of IL-17 in predicting the therapeutic effect of transcatheter arterial chemoembolization (TACE) combined with apartinib in patients with HCC in this study. METHODS:Established of IL-17 knockdown...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-200857

    authors： Wu Y,Cheng G,Chen H,Wang J,Wang J,Wang W

    更新日期：2020-07-09 00:00:00

  • Contrast enhanced ultrasound (CEUS) and time intensity curve (TIC) analysis in compartment syndrome: first results.

    abstract：OBJECTIVE:Purpose of this study was to monitor changes of microcirculation in acute compartment syndrome using contrast enhanced ultrasound (CEUS) and to assess the modified perfusion with a special quantification software. METHODS:8 patients with trauma of the lower limb or the upper extremity were enrolled after acu...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-2011-1438

    authors： Geis S,Gehmert S,Lamby P,Zellner J,Pfeifer C,Prantl L,Jung EM

    更新日期：2012-01-01 00:00:00

  • Angiogenesis around new AB-polymer networks after one week of implantation in mice.

    abstract：:Biomaterials research is expected to forward new materials to be used as, e.g., implant materials or as scaffolds for tissue engineering. It is central for such a scaffold material to create the track on which those cells can inhabit the scaffold needed to rebuild functional tissue substitutes. The tissue engineering ...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Binzen E,Rickert D,Kelch S,Fuhrmann R

    更新日期：2003-01-01 00:00:00