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The effects of Chinese herb Angelica in focal cerebral ischemia injury in the rat.

Abstract：

:This experiment was designed to study the therapeutic mechanisms of Angelica on the focal cerebral ischemia injury of the rat. The ischemic area was determined by TTC stain. And terminal deoxynucleotidyl transferase (TDT) mediated DUTP-biotin nick end labeling (TUNEL) method was applied to detect neuronal apoptosis. The expressions of Bcl-2 and Bax proteins were observed by immunohistochemical staining methods. Results show that the treatment with angelica reduced the volume of cerebral infarction (p < 0.05), and that the number of neuronal apoptosis cells decreased significantly (p < 0.01). Also the expression level of Bax protein decreased (p < 0.01). These results suggest that Angelica can reduce the number of apoptosis cells by decreasing the expression of Bax protein. This is maybe one of the mechanisms of the therapeutic effect of Angelica on focal cerebral ischemia injury.

journal_name

Clin Hemorheol Microcirc

journal_title

Clinical hemorheology and microcirculation

authors

Yang JW,Ouyang JP,Liao WJ,Tian J,Liu YM,Wei L,Wang BH,Li K

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

209-15

issue

3

eissn

1386-0291

issn

1875-8622

journal_volume

32

pub_type

杂志文章

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