The effect of cerebral lymphatic blockage on cortex regional cerebral blood flow and somatosensory evoked potential.

Abstract:

:Disputes on the significance of cerebral lymphatic drainage pathways under physiological and pathophysiological conditions still exist. The purpose of this experiment is to investigate the influence of cerebral lymphatic blockage on cerebral blood flow and cortex somatosensory evoked potential. Wistar rat cerebral lymphatic blockage models were established by removing cervical lymphatic nodes after obstructing their input and output tubes. Animals were divided randomly into a sham-operated group and a cerebral lymphatic-blockage group. Regional cerebral blood flow in different regions of the cortex were detected using a laser-Doppler flowmeter probe, and cortex evoked potential was detected using an electromyogram and evoked potential instrument before the operation, then 1 day, 5 days and 7 days after the operation. Results showed that the sham operation had no obvious effect on regional cerebral blood flow and the latency of somatosensory evoked potential. From 1 day to 7 days after cerebral lymphatic obstruction, regional cerebral blood flow in different cortical regions decreased markedly (P<0.01). Latency of somatosensory evoked potential was significantly delayed on the 5th and 7th day after blockage of cerebral lymphatic drainage (P<0.01). We concluded that cerebral lymphatic drainage may play an important role in maintaining the equilibrium of the internal environment of the brain, and blockage of this pathway results in cerebral ischemia.

authors

Xia ZL,Sun BL,Yang MF,Yuan H,Qiu PM,Chen YS

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

345-9

issue

3-4

eissn

1386-0291

issn

1875-8622

journal_volume

29

pub_type

杂志文章
  • Erythrocytes dynamic viscoelasticity in beta-thalassaemia minor.

    abstract::Beta-thalassaemia is a hereditary hemolytic disease, in which each clinic phenotype encompasses a heterogenic group of genetic alterations resulting in beta-globin chain synthesis decrease or absence in red blood cells. Studies on beta-thalassaemia carriers suggest the existence of decreased red cell deformability. Th...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Pérez SM,Riquelme B,Acosta I,Valverde J,Milani A

    更新日期:2006-01-01 00:00:00

  • Tetrahydrobiopterin improves microcirculation in experimental sepsis.

    abstract:BACKGROUND:Tetrahydrobiopterin (BH4), an endogenous nucleic acid derivative, acts as an important cofactor for several enzymes found within the vascular endothelium, which is deranged in sepsis. OBJECTIVE:We hypothesized that BH4 would improve capillary density and decrease inflammation within the intestinal microcirc...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/CH-160207

    authors: Dumbarton TC,Maxan A,Farah N,Sharawy N,Zhou J,Nantais J,Lehmann C

    更新日期:2017-01-01 00:00:00

  • The influence of cryoglobulins on the temperature-dependent erythrocyte aggregation in vitro by backscattering nephelometry.

    abstract::Nephelometry technique was used to register the alterations of the scattering signal from a whole blood sample due to erythrocyte aggregates in stasis and under controlled shear stress. The measured parameters were: the characteristic times of linear and three-dimensional aggregates formation, and the strength of aggr...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Konstantinova NA,Matveeva NA,Sirko IV,Firsov NN

    更新日期:2004-01-01 00:00:00

  • Nitric oxide metabolites (nitrite and nitrate) in young patients with recent acute myocardial infarction.

    abstract::Nitric oxide (NO) has a role in the pathophysiology of acute and chronic cardiovascular events. We studied the plasma concentration of NO stable end products (nitrite and nitrate--NOx) in 43 patients aged<46 years, with recent acute myocardial infarction (AMI). The evaluation was effected at the initial stage, after 3...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Caimi G,Montana M,Calandrino V,Caruso M,Carollo C,Catania A,Lo Presti R

    更新日期:2008-01-01 00:00:00

  • Formulation of drug-loaded oligodepsipeptide particles with submicron size.

    abstract::The size of particulate carriers is key to their transport and distribution in biological systems, and needs to be tailored in the higher submicron range to enable follicular uptake for dermal treatment. Oligodepsipeptides are promising nanoparticlulate carrier systems as they can be designed to exhibit enhanced inter...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-200977

    authors: Brunacci N,Wischke C,Naolou T,Patzelt A,Lademann J,Neffe AT,Lendlein A

    更新日期:2020-11-11 00:00:00

  • Angiogenesis: the role of PDGF-BB on adipose-tissue derived stem cells (ASCs).

    abstract::Recently, it was shown that mesenchymal stem cells (MSCs) are capable of differentiating into endothelial cells which highlights the potential role of MSCs in neovascularization. In the present study, we investigated the paracrine factors responsible for tube formation in human adipose-tissue derived stem cells (ASCs)...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2011-1397

    authors: Gehmert S,Gehmert S,Hidayat M,Sultan M,Berner A,Klein S,Zellner J,Müller M,Prantl L

    更新日期:2011-01-01 00:00:00

  • Effects of cardiotonic pill on RBC rheologic abnormalities in HFD-induced mice and LPL deficient mice.

    abstract::The lipoprotein lipase deficient (LPL-/-) mice and high fat-diet (HFD) induced hypertriglyceridemic mice were used to investigate the effects of cardiotonic pill (CP) on RBC rheologic abnormalities. Mice were randomly divided into the following five groups: the control group; the untreated HFD group; the untreated LPL...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Wang XW,Guo J,Wang XF,Chen XP,Wen ZY

    更新日期:2008-01-01 00:00:00

  • Erythrocyte deformability in morbid obesity before bariatric surgery. Influence of abdominal obesity.

    abstract::Although there are several studies dealing with erythrocyte deformability (ED) in obese patients, research on this topic in morbidly obese subjects is scarce. In these studies ED seems to be decreased, although the cause remains unknown. A case-control study in 76 morbid obese subjects (23 women and 53 men, aged 44 ± ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2010-1357

    authors: Vayá A,Cámara R,Hernádez-Mijares A,Romagnoli M,Solá E,Corella D,Laiz B

    更新日期:2010-01-01 00:00:00

  • Association of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage: the J-SHIP and Toon Health Study.

    abstract:BACKGROUND:Elevated hematocrit levels have been suggested to be an independent determinant of insulin resistance and type 2 diabetes. To clarify the diagnostic significance of hematocrit level, we investigated the association with hemodynamic profiles, insulin resistance and insulin sensitivity, arterial properties, an...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2012-1634

    authors: Tabara Y,Igase M,Saito I,Nishida W,Kohara K,Sakurai S,Kawamura R,Okada Y,Hitsumoto S,Onuma H,Nagai T,Takata Y,Uetani E,Takita R,Kido T,Ochi N,Osawa H,Tanigawa T,Miki T

    更新日期:2013-01-01 00:00:00

  • Absent post-ischemic increase of blood flowmotion in the cutaneous microcirculation of healthy chronic cigarette smokers.

    abstract::The aim of the study was to investigate whether chronic cigarette smoke habit is associated with changes of laser Doppler (LD) skin blood flowmotion (SBF). We performed spectral analysis of skin forearm LD signal detected by a LD flowmetry (Periflux PF4, Perimed, Sweden) before and during forearm post-ischemic hyperae...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Rossi M,Carpi A,Di Maria C,Galetta F,Santoro G

    更新日期:2007-01-01 00:00:00

  • Hemorheology of growth hormone-deficient adults.

    abstract::Growth hormone deficiency (GHD) in adults results in alterations of body composition and metabolism associated with a lowered insulin sensitivity and an increased cardiovascular risk. Since hemorheologic disturbances (putative factors of vascular risk) are found in the insulin-resistance syndrome, we investigated bloo...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Peyreigne C,Fédou C,Benhaddad AA,de Boisvilliers F,Mercier J,Bringer J,Brun JF

    更新日期:1999-01-01 00:00:00

  • Modulating human mesenchymal stem cells using poly(n-butyl acrylate) networks in vitro with elasticity matching human arteries.

    abstract::Non-swelling hydrophobic poly(n-butyl acrylate) network (cPnBA) is a candidate material for synthetic vascular grafts owing to its low toxicity and tailorable mechanical properties. Mesenchymal stem cells (MSCs) are an attractive cell type for accelerating endothelialization because of their superior anti-thrombosis a...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-189418

    authors: Wang W,Xu X,Li Z,Kratz K,Ma N,Lendlein A

    更新日期:2019-01-01 00:00:00

  • The role of GST polymorphism in reperfusion induced oxidative stress, inflammatory responses and clinical complications after surgical and percutaneous coronary intervention.

    abstract:BACKGROUND:Patients having coronary artery disease treated by coronary bypass or PCI procedure are exposed to tissue damage because of the phenomenon called reperfusion injury. Reperfusion injury can be characterized/monitored by oxidative stress parameters, inflammatory markers and by post-operative complication rate....

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/CH-170270

    authors: Pintér Ö,Hardi P,Nagy T,Gasz B,Kovács V,Arató E,Sínay L,Lénárd L,Jancsó G

    更新日期:2017-01-01 00:00:00

  • Performance evaluation of the Anysis-200 platelet function analyzer in cardiac patients.

    abstract:BACKGROUND:Platelet function analysis is crucial in assessing the hemostatic status to evaluate congenital and acquired platelet function defects. The Anysis-200 analyzer is a new automated lab-on-a-chip-based platelet function analyzer. OBJECTIVE:We aimed to evaluate a new platelet function analyzing system, the Anys...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-190801

    authors: Park SJ,Yoon J,Seo HS,Lim CS

    更新日期:2020-02-24 00:00:00

  • Contrast enhanced ultrasound (CEUS) to assess pleural pulmonal changes in severe COVID-19 infection: First results.

    abstract:AIM:Use of contrast enhanced ultrasound (CEUS) in severe cases of COVID-19 infection to assess pulmonary changes near the pleura. MATERIAL AND METHODS:Bedside examinations by an experienced intensive care unit examiner using a multi-frequency probe (C1-6 MHz) with B-mode and CEUS to assess pleural-near changes in seve...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-209005

    authors: Jung EM,Stroszczynski C,Jung F

    更新日期:2020-01-01 00:00:00

  • Prospective evaluation of 4-D contrast-enhanced-ultrasound (CEUS) imaging in bladder tumors.

    abstract:PURPOSE:The evaluation of the potential clinical benefit of four-dimensional ultrasound (4D-US) in the assessment of bladder cancer (BC). MATERIAL AND METHODS:20 patients with indication for cystoscopy for suspicion of bladder cancer were prospectively included in this study. All patients underwent two-dimensional ult...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-199231

    authors: Jokisch F,Buchner A,Schulz GB,Grimm T,Weinhold P,Pfitzinger PL,Chaloupka M,Stief CG,Schlenker B,Clevert DA

    更新日期:2020-01-01 00:00:00

  • Numerical investigation on red blood cell dynamics in microflow: Effect of cell deformability.

    abstract::The radial dispersion of red blood cells (RBCs) near the vessel wall can significantly affect the transport dynamics in small vessels. The radial dispersion of RBCs is mainly caused by collisions between RBCs and this can be enhanced by aggregation. The objective of this study is to numerically investigate on the effe...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-16128

    authors: Ju M,Leo HL,Kim S

    更新日期:2017-01-01 00:00:00

  • Contrast-enhanced ultrasound versus CT and operative findings in evaluation of renal vein aneurysm with AV fistula.

    abstract::We report the case of a 61-year-old patient admitted to our hospital owing to recent nonspecific abdominal pain. Five years earlier he had been treated with a graft owing to thoracic and abdominal aortic aneurysm with dissection. He now showed a left renal vein aneurysm with a diameter of 11x7.5 cm. This case demonstr...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Clevert DA,Stickel M,Kopp R,Weidenhagen R,Fink C,Jauch KW,Reiser M

    更新日期:2008-01-01 00:00:00

  • The influence of a multifunctional, polymeric biomaterial on the concentration of acute phase proteins in an animal model.

    abstract::The concentrations of the acute phase proteins alpha1-Acid Glycoprotein (AAG) and haptoglobin were determined in Sprague-Dawley-rats after implantation of a novel biodegradable multifunctional polymeric biomaterial for the reconstruction of a gastric wall defect (polymer group; n=42). For comparison, the concentration...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Rickert D,Scheithauer MO,Coskun S,Kelch S,Lendlein A,Franke RP

    更新日期:2007-01-01 00:00:00

  • Follow-up after focal therapy of the prostate with high intensity focused ultrasound (HIFU) using contrast enhanced ultrasound (CEUS) in combination with MRI image fusion.

    abstract:INTRODUCTION:Focal therapy (FT) of the prostate for low risk prostate cancer (PCa) is an alternative to traditional definite treatment options like external beam radiotherapy or radical prostatectomy. However, follow up after FT is still challenging and is subject to current studies. Significance of imaging after FT su...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-199222

    authors: Apfelbeck M,Chaloupka M,Schlenker B,Stief CG,Clevert DA

    更新日期:2019-01-01 00:00:00

  • The combined effects of the microcirculatory status and cardiopulmonary bypass on platelet count and function during cardiac surgery.

    abstract:BACKGROUND:Cardiac surgery with cardiopulmonary bypass is associated with important changes in the microcirculation, usually attributed to endothelial dysfunction. Another common finding of cardiac surgery is postoperative thrombocytopenia and platelet loss of function. OBJECTIVE:To investigate the association between...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-180391

    authors: Di Dedda U,Ranucci M,Porta A,Bari V,Ascari A,Fantinato A,Baryshnikova E,Cotza M

    更新日期:2018-01-01 00:00:00

  • Hemorheological methods in drug research.

    abstract::Development of new drugs is a sophisticated process that requires several, different methods. In our experiments we have applied two rheological models to study experimental and clinically used drugs. The antioxidant properties of several agents were estimated by erythrocyte filtration technique. The known antioxidant...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Marton Z,Halmosi R,Alexy T,Horvath B,Toth A,Feher G,Koltai K,Kesmarky G,Habon T,Sumegi B,Hideg K,Toth K

    更新日期:2004-01-01 00:00:00

  • Interaction of thrombocytes with poly(ether imide): The influence of processing.

    abstract::The processing of polymers for blood contacting devices can have a major influence on surface properties. In this study, we fabricated poly(ether imide) (PEI) membranes and films to investigate the effects of the processing on physicochemical surface properties by atomic force microscopy (AFM), scanning electron micro...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2010-1351

    authors: Braune S,Lange M,Richau K,Lützow K,Weigel T,Jung F,Lendlein A

    更新日期:2010-01-01 00:00:00

  • Effects of radiation on the expression of adhesion molecules and cytokines in a static model of human dermal microvascular endothelial cells.

    abstract:BACKGROUND:Radiation-induced wound healing complications represent an important clinical problem. Microvascular compromise is an important component of its pathogenesis and the microvascular endothelial cell is the key representative affected at the cellular level. MATERIAL AND METHODS:Human dermal microvascular endot...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2012-1626

    authors: Haubner F,Ohmann E,Pohl F,Prantl L,Strutz J,Gassner HG

    更新日期:2013-01-01 00:00:00

  • Effects of storage duration and temperature of human blood on red cell deformability and aggregation.

    abstract::Blood samples used in hemorheological studies may be stored for a period of time, the effects of storage have yet to be fully explored. This study evaluated the effects of storage temperature (i.e., 4 degrees C or 25 degrees C) and duration on RBC deformability and aggregation for blood from healthy controls and from ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2009-1178

    authors: Uyuklu M,Cengiz M,Ulker P,Hever T,Tripette J,Connes P,Nemeth N,Meiselman HJ,Baskurt OK

    更新日期:2009-01-01 00:00:00

  • Evaluation of different methods used to measure malonyldialdehyde in human erythrocytes.

    abstract::Malonyldialdehyde (MDA), a secondary product of lipid peroxidation is widely used as an indicator of lipid peroxidation. Eight of the most frequently used methods for measuring MDA have been evaluated with regard to their sensitivity and reproducibility. The sensitivity of these methods for pure MDA solution was in th...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Srour MA,Bilto YY,Juma M

    更新日期:2000-01-01 00:00:00

  • A new simple cone-plate viscometer for hemorheology.

    abstract::The aim of this work was to evaluate a new automatic cone-plate viscometer (LBY-N6, PRECIL, Beijing, China) which was designed for clinical measurements of blood and plasma viscosities. Standard calibrating oils of viscosity varying from 1.85 to 20.5 mPas (conforming to ASTM Standard) were used to test the precision a...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Wang X,Liao FL,Stoltz JF

    更新日期:1998-09-01 00:00:00

  • Blood rheological abnormalities in sickle cell anemia.

    abstract::This review focuses on the contribution of abnormal blood rheology in the pathophysiology of sickle cell anemia (SCA). SCA is characterized by a reduction of red blood cell (RBC) deformability but this reduction is very heterogeneous among patients. Recent works have shown that patients with the lowest RBC deformabili...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-189005

    authors: Connes P,Renoux C,Romana M,Abkarian M,Joly P,Martin C,Hardy-Dessources MD,Ballas SK

    更新日期:2018-01-01 00:00:00

  • Elevated hematocrit in nonalcoholic fatty liver disease: a potential cause for the increased risk of cardiovascular disease?

    abstract:BACKGROUND AND AIM:Hematocrit is an important hemorheological parameter. Both hematocrit and nonalcoholic fatty liver disease (NAFLD) are strongly correlated with cardiovascular disease. However, there is no study to explore the direct relationship of hematocrit with NAFLD. METHODS:Hematocrit levels were analyzed from...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2011-1509

    authors: Li G,Hu H,Shi W,Li Y,Liu L,Chen Y,Hu X,Wang J,Gao J,Yin D

    更新日期:2012-01-01 00:00:00

  • Erythrocyte deformability and nitric oxide mobilization under pannexin-1 and PKC dependence.

    abstract::The erythrocyte adenosine triphosphate (ATP) is utilised for protein phosphorylation and exported through the pannexin 1 hemichannel (Px1) in the microcirculation. The physiological stimuli for ATP release are dependent of blood shear rate level and of the tissue oxygen content. The deoxygenated and oxygenated states ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-141833

    authors: Silva-Herdade AS,Freitas T,Almeida JP,Saldanha C

    更新日期:2015-01-01 00:00:00