Erythrocyte as a biological sensor.

Abstract:

:The erythrocytes ability of sensing the local oxygen gradient through the hemoglobin conformation, along with changes in nitric oxide mobilization and vasomotor repercussions at the microcirculation, were reviewed in detail in this article. Different approachs trying to explain the erythrocyte death were additionally documented. Also, the influence of several types of molecules (vasoactive, oxidant/reductor) on the erythrocyte roles as sensor of (i) oxygen tissue needs, (ii) blood viscosity and myogenic environment, (iii) and inflammatory conditions were mentioned in order to highlight its physiologycal function and substitute the erroneous idea of the erythrocyte being simply a hemoglobin sac content.

authors

Lopes de Almeida JP,Oliveira S,Saldanha C

doi

10.3233/CH-2011-1512

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

1-20

issue

1

eissn

1386-0291

issn

1875-8622

pii

R758367NX3847833

journal_volume

51

pub_type

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