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A long-distance fluid transport pathway within fibrous connective tissues in patients with ankle edema.

Abstract：

OBJECTIVES:Although the microcirculatory dysfunctions of edema formation are well documented, the draining pattern of dermal edema lacks information. This study was to assess the potential drainage pathways of the interstitial fluid in patients with ankle edema using the anatomical and histological methods. METHODS AND RESULTS:Four amputees of lower leg participated in this study. Fluorescent imaging agent was injected into lateral ankle dermis in one volunteered patient before the amputation and three lower legs after the amputation. Physiologically in the volunteer or enhanced by cyclical compression on three amputated limbs, several fluorescent longitudinal pathways from ankle dermis to the broken end of the amputated legs were subsequently visualized and studied using histological methods, laser confocal microscopy and electron microscopy methods respectively. Interestingly, the fluorescent pathways confirmed to be fibrous connective tissues and the presence of two types: those of the cutaneous pathway (located in dermis or the interlobular septum among adipose tissues within the hypodermis) and those of the perivascular pathway (located in connective tissues surrounding the veins and the arteries). The intrinsic three-dimensional architecture of each fluorescent pathway was the longitudinally running and interconnected fibril bundles, upon which, an interfacial transport pathway within connective tissues was visualized by fluorescein. CONCLUSIONS:The current anatomical data suggested that a unique long-distance transport pathway composed of oriented fibrous connective tissues might play a pathophysiological role in draining dermal edema besides vascular circulations and provide novel understandings of general fibrous connective tissues in life science.

journal_name

Clin Hemorheol Microcirc

journal_title

Clinical hemorheology and microcirculation

authors

Li H,Yang C,Lu K,Zhang L,Yang J,Wang F,Liu D,Cui D,Sun M,Pang J,Dai L,Han D,Liao F

doi

10.3233/CH-162057

subject

Has Abstract

pub_date

2016-10-05 00:00:00

pages

411-421

issue

eissn

1386-0291

issn

1875-8622

pii

CH2057

journal_volume

pub_type

杂志文章

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A long-distance fluid transport pathway within fibrous connective tissues in patients with ankle edema.