Abstract：
BACKGROUND:Hemodialysis patients have increased mortality from cardiovascular complications. Whole blood viscosity (WBV) and red cell aggregation (RCA) may influence the pathogenesis of vascular complications in this population. The objective of this study was to determine whether the hemodialysis treatment or vascular complications were associated with impaired WBV or RCA. METHODS:This prospective, cross sectional investigation included 38 patients receiving chronic hemodialysis. Blood samples for WBV, RCA and hematocrit were drawn before and after dialysis. WBV was determined between 10 and 780 s-1 and RCA was measured by calculating aggregate shape parameter. WBV and RCA were subsequently assessed for correlation with a history of vascular disease. RESULTS:The mean WBV, aggregate shape parameter, and hematocrit post-dialysis were significantly higher than pre-dialysis values (p < 0.05). Using a linear model with WBV as the dependent variable, the covariates of aggregate shape parameter, hematocrit, weight, and history of diabetes were not significant. However, pre/post timing of the sample was a significant covariate. WBV correlated with prior access thrombosis or stenosis, especially if the patient had a history of peripheral vascular disease. CONCLUSIONS:Higher WBV correlated with an increased incidence of access failure and vascular disease. Repetitive increases in WBV and RCA with each dialysis treatment could contribute to vascular dysfunction in this patient population.
journal_name
Clin Hemorheol Microcircjournal_title
Clinical hemorheology and microcirculationauthors
Dhar P,Eadon M,Hallak P,Munoz RA,Hammes Mdoi
10.3233/CH-2012-1532subject
Has Abstractpub_date
2012-01-01 00:00:00pages
265-75issue
4eissn
1386-0291issn
1875-8622pii
U453216578Q740RJjournal_volume
51pub_type
杂志文章abstract：:A new technique is sweeping the world, and changing the course of human work and life. It is impacting upon models, methods and the development of medical research. In the development of this new technique, a huge quantity of experimental research and clinical practice has proved that many human diseases have a close ...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：:Primary closure in dermatologic surgery is state of the art in small lesions at the head, but also in larger lesions at the trunk or the extremities. Microcirculatory effects on the skin blood flow near to the wound edges affected by primary closure. Forty three patients were investigated. Before and after surgery, sk...
journal_title：Clinical hemorheology and microcirculation
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abstract：OBJECTIVES:As most clinical studies measure whole blood viscosity (WBV) from peripheral samples, potential differences in WBV obtained from the coronary arteries are often ignored. This study investigated differences in WBV measured from coronary artery specimens in patients with and without acute coronary syndrome (AC...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-131692
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abstract：:A simple and reproducible 'syringe viscometer' method was used to determine plasma viscosity, an important haemorheological parameter, in 27 (14 M, 13 F) nephrotic Nigerian patients. The plasma fibrinogen (PFC) and immunoglobulin levels (IgG, IgM, IgA) were also determined in these patients. Similar determinations wer...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：INTRODUCTION:Using standard cell biological and biochemical experimental approaches we were able to test the ability of a particular polymer construct to support the adhesion, proliferation, and the cellular acitivity of pharyngeal cells. The delicate balance between Matrix Metalloproteinases (MMPs) and their endogenou...
journal_title：Clinical hemorheology and microcirculation
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abstract：:Determination of shear stresses at given shear rates allow approximation of flow curves by mathematical models and to calculate viscosities of non-Newtonian fluids. In term neonates, the mean arterial blood pressure (MAP) is markedly below that of adults, therefore rheological properties of blood play an important rol...
journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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abstract：:Bioelectrical impedancemetry (BIA) has been used to evaluate hemorheological parameters from whole body measurements. In a previous study, we have determined a set of predictive equations for hematocrit, whole blood viscosity and plasma viscosity in athletes. In another previous study, we also found other predictive e...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:To evaluate the different ultrasound techniques for quantification of contrast enhanced ultrasound (CEUS) in an experimental rat prostate carcinoma model. METHOD AND MATERIALS:Prostate carcinoma (MLLB-2) cells were subcutaneously injected into the right flank of male rat (Charles River, Sulzfeld, Germany, 180 ...
journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2002-01-01 00:00:00
abstract：:Polycarbonate (PC) substrate is well suited for culturing human mesenchymal stem cells (MSCs) with high proliferation rate, low cell apoptosis rate and negligible cytotoxic effects. However, little is known about the influence of PC on MSC activity including senescence, differentiation and secretion. In this study, th...
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章,随机对照试验
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
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更新日期：2000-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
