Plasma viscosity in nephrotic Nigerians.

Abstract:

:A simple and reproducible 'syringe viscometer' method was used to determine plasma viscosity, an important haemorheological parameter, in 27 (14 M, 13 F) nephrotic Nigerian patients. The plasma fibrinogen (PFC) and immunoglobulin levels (IgG, IgM, IgA) were also determined in these patients. Similar determinations were carried out in 30 (15 M, 15 F) age- and sex-matched healthy control subjects for comparison. The nephrotic patients had significantly higher relative plasma viscosity (RPV), PFC and IgM levels (2.02+/-0.17 vs. 1.66+/-0.19, 6.48+/-2.59 vs. 2.26+/-0.91 g/l; 316.2+/-169.0 vs. 186.0+/-59.5 IU/ml, p < 0.001, respectively). However, IgG and IgA levels were significantly less (151.1+/-88.7 vs. 205.7+/-77.6 IU/ml, p < 0.05, and 95.8+/-41.5 vs. 127.3+/-31.3 IU/ml, p < 0.01, respectively). In the nephrotic patients, plasma fibrinogen and IgM levels had a significant positive correlation with RPV (r=0.444, p < 0.05, and r=0.452, p < 0.02, respectively). The observed increased plasma viscosity in our nephrotic patients could on the long term predispose them to increased risk for cardiovascular morbidity.

authors

Oviasu E,Famodu AA,Ojeh EA

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

163-7

issue

2

eissn

1386-0291

issn

1875-8622

journal_volume

19

pub_type

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