当前位置： SCI文献检索 > CLINICAL HEMORHEOLOGY AND MICROCIRCULATION期刊下所有文献 > The interaction of adipose-derived human mesenchymal stem cells and polyether ether ketone.

The interaction of adipose-derived human mesenchymal stem cells and polyether ether ketone.

Abstract：

:Polyether ether ketone (PEEK) as a high-performance, thermoplastic implant material entered the field of medical applications due to its structural function and commercial availability. In bone tissue engineering, the combination of mesenchymal stem cells (MSCs) with PEEK implants may accelerate the bone formation and promote the osseointegration between the implant and the adjacent bone tissue. In this concept the question how PEEK influences the behaviour and functions of MSCs is of great interest. Here the cellular response of human adipose-derived MSCs to PEEK was evaluated and compared to tissue culture plate (TCP) as the reference material. Viability and morphology of cells were not altered when cultured on the PEEK film. The cells on PEEK presented a high proliferation activity in spite of a relatively lower initial cell adhesion rate. There was no significant difference on cell apoptosis and senescence between the cells on PEEK and TCP. The inflammatory cytokines and VEGF secreted by the cells on these two surfaces were at similar levels. The cells on PEEK showed up-regulated BMP2 and down-regulated BMP4 and BMP6 gene expression, whereas no conspicuous differences were observed in the committed osteoblast markers (BGLAP, COL1A1 and Runx2). With osteoinduction the cells on PEEK and TCP exhibited a similar osteogenic differentiation potential. Our results demonstrate the biofunctionality of PEEK for human MSC cultivation and differentiation. Its clinical benefits in bone tissue engineering may be achieved by combining MSCs with PEEK implants. These data may also provide useful information for further modification of PEEK with chemical or physical methods to regulate the cellular processes of MSCs and to consequently improve the efficacy of MSC-PEEK based therapies.

journal_name

Clin Hemorheol Microcirc

journal_title

Clinical hemorheology and microcirculation

authors

Wang W,Kratz K,Behl M,Yan W,Liu Y,Xu X,Baudis S,Li Z,Kurtz A,Lendlein A,Ma N

doi

10.3233/CH-152001

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

301-21

issue

2

eissn

1386-0291

issn

1875-8622

pii

CH2001

journal_volume

61

pub_type

杂志文章

相关文献

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION文献大全
  • First results of endocavity evaluation of the microvascularization of malignant prostate tumors using contrast enhanced ultrasound (CEUS) including perfusion analysis: first results.

    abstract：AIM:Detection of prostate cancer lesions using transrectal contrast enhanced ultrasound (CEUS) of the prostate utilizing quantitative perfusion analysis. METHOD:20 patients (mean age 63 years, 47-71) with biopsy proven prostate cancer underwent transrectal ultrasound (TRUS) prior to radical prostatectomy by 2 experien...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-2012-1594

    authors： Jung EM,Wiggermann P,Greis C,Eder F,Ehrich J,Jung W,Schreyer AG,Stroszczynski C,Ganzer R

    更新日期：2012-01-01 00:00:00

  • Influence of the direct NO-donor SIN-1 on the interaction between platelets and stainless steel stents under dynamic conditions.

    abstract：:It was investigated whether the NO-donor SIN-1, the active metabolite of molsidomine, influenced the activation of platelets, the formation of circulating platelet aggregates, the spontaneous aggregation of platelets and the activation of the clotting system triggered by a body foreign surface in an in vitro closed-lo...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Jung F,Mrowietz C,Seyfert UT,Grewe R,Franke RP

    更新日期：2003-01-01 00:00:00

  • Pneumoperitoneum induced ischemia-reperfusion injury of the peritoneum - Preconditioning may reduce the negative side-effects caused by carbon-dioxide pneumoperitoneum - Pilot study.

    abstract：INTRODUCTION:Laparoscopy is more beneficial than the conventional open technique, however the pneumoperitoneum created may have an ischemic side effect. OBJECTIVE:Our aim was to evaluate the protective effects of preconditioning during laparoscopic cholecystectomies (LC). METHODS:30 patients were randomized into 2 gr...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-170336

    authors： Veres TG,Takács I,Nagy T,Jancsó G,Kondor A,Pótó L,Vereczkei A

    更新日期：2018-01-01 00:00:00

  • Effects of storage duration and temperature of human blood on red cell deformability and aggregation.

    abstract：:Blood samples used in hemorheological studies may be stored for a period of time, the effects of storage have yet to be fully explored. This study evaluated the effects of storage temperature (i.e., 4 degrees C or 25 degrees C) and duration on RBC deformability and aggregation for blood from healthy controls and from ...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-2009-1178

    authors： Uyuklu M,Cengiz M,Ulker P,Hever T,Tripette J,Connes P,Nemeth N,Meiselman HJ,Baskurt OK

    更新日期：2009-01-01 00:00:00

  • Folate receptor mediated genetic modification of human mesenchymal stem cells via folic acid-polyethylenimine-grafted poly(N-3-hydroxypropyl)aspartamide.

    abstract：:Mesenchymal stem cells (MSCs) are targeted as vehicles for cell mediated gene therapy. Here we report on a macromolecular carrier, which was designed aiming at successful targeted gene delivery into MSCs through the mediation of folate receptor and reduced cytotoxicity compared to established cationic polymer vector -...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-179209

    authors： Wang W,Li W,Wang J,Hu Q,Balk M,Bieback K,Stamm C,Jung F,Tang G,Lendlein A,Ma N

    更新日期：2017-01-01 00:00:00

  • Methods in hemorheology and their clinical applications1.

    abstract：:The lecture was presented during the Fåhraeus award ceremony for 2016 at the University of Lisbon. It summarizes the main results and some of the more important hemorheological contributions achieved in the Laboratory of Biodynamics and Biorheology of the Institute of Mechanics to BAS and in collaboration with other l...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-168001

    authors： Antonova N

    更新日期：2016-01-01 00:00:00

  • Erythrocytes dynamic viscoelasticity in beta-thalassaemia minor.

    abstract：:Beta-thalassaemia is a hereditary hemolytic disease, in which each clinic phenotype encompasses a heterogenic group of genetic alterations resulting in beta-globin chain synthesis decrease or absence in red blood cells. Studies on beta-thalassaemia carriers suggest the existence of decreased red cell deformability. Th...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Pérez SM,Riquelme B,Acosta I,Valverde J,Milani A

    更新日期：2006-01-01 00:00:00

  • Veno-active drugs in the management of chronic venous disease. An international consensus statement: current medical position, prospective views and final resolution.

    abstract：BACKGROUND:Veno-active drugs (VAD) have effects on edema and symptoms related to chronic venous disease (CVD), especially so-called venous pain. VAD's effectiveness, although well established, is regularly debated. OBJECTIVE:Our purpose was to select all randomized controlled trials (RCTs) and meta-analyses devoted to...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章,评审

    doi：

    authors： Ramelet AA,Boisseau MR,Allegra C,Nicolaides A,Jaeger K,Carpentier P,Cappelli R,Forconi S

    更新日期：2005-01-01 00:00:00

  • Alterations of serum erythropoietin and thrombopoietin levels in patients undergoing Coronary Artery Bypass Grafting (CABG).

    abstract：INTRODUCTION:The hormones erythropoietin (EPO) and thrombopoietin (TPO) are main regulators of erythro- and thrombopoiesis. Cell loss caused by operative procedures may alter serum levels of the hormones, resulting in well known phenomenons like reactice thrombocytosis. MATERIAL AND METHODS:Blood samples from 10 patie...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-2011-1489

    authors： Wenzel F,Gettmann T,Zimmermann N,Giers G

    更新日期：2011-01-01 00:00:00

  • A long-distance fluid transport pathway within fibrous connective tissues in patients with ankle edema.

    abstract：OBJECTIVES:Although the microcirculatory dysfunctions of edema formation are well documented, the draining pattern of dermal edema lacks information. This study was to assess the potential drainage pathways of the interstitial fluid in patients with ankle edema using the anatomical and histological methods. METHODS AN...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-162057

    authors： Li H,Yang C,Lu K,Zhang L,Yang J,Wang F,Liu D,Cui D,Sun M,Pang J,Dai L,Han D,Liao F

    更新日期：2016-10-05 00:00:00

  • Hemorheological methods in drug research.

    abstract：:Development of new drugs is a sophisticated process that requires several, different methods. In our experiments we have applied two rheological models to study experimental and clinically used drugs. The antioxidant properties of several agents were estimated by erythrocyte filtration technique. The known antioxidant...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Marton Z,Halmosi R,Alexy T,Horvath B,Toth A,Feher G,Koltai K,Kesmarky G,Habon T,Sumegi B,Hideg K,Toth K

    更新日期：2004-01-01 00:00:00

  • Metabolic alterations in morbid obesity. Influence on the haemorheological profile.

    abstract：:There are few studies on haemorheological disturbances in morbidly obese patients. The role played by the metabolic syndrome on the rheological profile of morbidly obese subjects has not yet been established, and it is not clear whether morbidly obese, but "metabolically healthy", show rheological alterations. We aime...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-2011-1417

    authors： Vayá A,Hernández-Mijares A,Suescun M,Solá E,Cámara R,Romagnoli M,Bautista D,Laiz B

    更新日期：2011-01-01 00:00:00

  • The influence of cryoglobulins on the temperature-dependent erythrocyte aggregation in vitro by backscattering nephelometry.

    abstract：:Nephelometry technique was used to register the alterations of the scattering signal from a whole blood sample due to erythrocyte aggregates in stasis and under controlled shear stress. The measured parameters were: the characteristic times of linear and three-dimensional aggregates formation, and the strength of aggr...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Konstantinova NA,Matveeva NA,Sirko IV,Firsov NN

    更新日期：2004-01-01 00:00:00

  • Aggregability and disaggregability of erythrocytes in women suffering from ovarian cancer: evidence for an increased disaggregation threshold.

    abstract：:In order to further characterize the alterations of erythrocyte aggregation described in ovarian cancer, we measured it with laser backscattering in eleven women suffering from ovarian cancer (mean age: 44.7 +/- 3.6, extreme values: 28-61 yr) compared with thirteen matched control women. Blood rheology exhibited a wid...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： El Bouhmadi A,Laffargue F,Brun JF

    更新日期：2000-01-01 00:00:00

  • The use of antithrombotic agents in microvascular surgery.

    abstract：:Despite increasing advances in microvascular free tissue transfer, flap failures, most commonly resulting from thrombosis at the anastomotic vascular site, remain a significant concern. Although several experimental and clinical studies have been carried out, no consensus has been reached so far on the efficacy, dosag...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章,评审

    doi：10.3233/CH-2009-1220

    authors： Stephan B,Schenk JF,Nemeh A,Pindur G

    更新日期：2009-01-01 00:00:00

  • Erythrocyte deformability in morbid obesity before bariatric surgery. Influence of abdominal obesity.

    abstract：:Although there are several studies dealing with erythrocyte deformability (ED) in obese patients, research on this topic in morbidly obese subjects is scarce. In these studies ED seems to be decreased, although the cause remains unknown. A case-control study in 76 morbid obese subjects (23 women and 53 men, aged 44 ± ...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-2010-1357

    authors： Vayá A,Cámara R,Hernádez-Mijares A,Romagnoli M,Solá E,Corella D,Laiz B

    更新日期：2010-01-01 00:00:00

  • Red blood cell distribution width and erythrocyte deformability in patients with acute myocardial infarction.

    abstract：:Increased RDW has been found to be a marker of adverse outcomes in cardiovascular disease (CVD), although the exact mechanism remains unclear. Recently, several authors have found that higher RDW is associated with decreased erythrocyte deformability, which can impair blood flow through microcirculation, a fact which ...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-131751

    authors： Vayá A,Rivera L,de la Espriella R,Sanchez F,Suescun M,Hernandez JL,Fácila L

    更新日期：2015-01-01 00:00:00

  • Determination of whole blood and plasma viscosity in term neonates by flow curve analysis with the LS300 viscometer1.

    abstract：:Determination of shear stresses at given shear rates allow approximation of flow curves by mathematical models and to calculate viscosities of non-Newtonian fluids. In term neonates, the mean arterial blood pressure (MAP) is markedly below that of adults, therefore rheological properties of blood play an important rol...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-152008

    authors： Kuss N,Bauknecht E,Felbinger C,Gehm J,Gehm L,Pöschl J,Ruef P

    更新日期：2015-10-06 00:00:00

  • Chronic liver disease: Correlation of CEUS-based microperfusion and indocyanine green clearance.

    abstract：PURPOSE:To evaluate whether changes of dynamic contrast-enhanced ultrasound (CEUS)-based liver microcirculation during chronic liver disease are correlated with the extent of impaired liver function, expressed by the indocyanine green (ICG) clearance. MATERIALS AND METHODS:19 patients underwent CEUS examinations with ...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-151990

    authors： Haimerl M,Jung EM,Beyer LP,Pregler B,Dollinger M,Sieroń D,Niessen C,Stroszczynski C,Wiggermann P

    更新日期：2015-01-01 00:00:00

  • Partially cystic thyroid nodules on ultrasound: The associated factors for malignancy.

    abstract：OBJECTIVES:To identify the associated factors for malignancy in partially cystic thyroid nodules (PCTNs) on ultrasound (US). MATERIALS AND METHODS:This is a retrospective study. 338 PCTNs confirmed by surgery was included in this study. The US features of the nodules were reviewed and their significance in differentia...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-190582

    authors： Shi YZ,Jin Y,Zheng L

    更新日期：2020-01-01 00:00:00

  • 3D monitoring of tumor volume in an in vivo model.

    abstract：BACKGROUND:The ability to evaluate tumor development within experimental oncology is of upmost importance. However, determining tumor volumes in 3D in vivo tumor models is challenging. The chick chorioallantoic membrane (CAM) model represents an optimized xenograft model that surpasses many disadvantages that are inher...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-209216

    authors： Troebs J,Asam C,Pion E,Prantl L,Aung T,Haerteis S

    更新日期：2020-01-01 00:00:00

  • Ultrasound elastography for the detection of capsular fibrosis in breast implants: First results.

    abstract：BACKGROUND:Capsular contractures around breast implants usually develop leading to pain and aesthetically inadequate results and ultimately often requires the replacement of the implants. Textured silicone implants are the most commonly placed implant, but polyurethane-coated implants are increasingly being used in an ...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-200875

    authors： Jung E,Hösl V,von Fraunberg S,Jung F,Prantl L

    更新日期：2020-09-08 00:00:00

  • Plasma nitric oxide level is correlated with microvascular functions in the peripheral arterial disease.

    abstract：:At present there is no widely accepted biomarker for monitoring of vascular functions. The purpose of this prospective study was to investigate the association of some blood biomarkers with vascular reactivity in patients with peripheral arterial diseases (PAD). A prospective evaluation was made of 3 groups comprising...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-16143

    authors： Akkoca M,Usanmaz SE,Koksoy C,Bengisun U,Demirel-Yilmaz E

    更新日期：2017-01-01 00:00:00

  • Increased hematocrit and reduced blood pressure following control of glycemia in diabetes.

    abstract：:In this study we determine the effects of reducing blood glucose on mean arterial blood pressure (MAP) and hematocrit (Hct) in patients with type 2 diabetes who are not responding to conventional treatment in an intensive treatment program 1 year after initiation of treatment. Data on MAP, glucose and Hct was obtained...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 临床试验,杂志文章

    doi：

    authors： Salazar Vázquez BY,Salazar Vázquez MA,Venzor VC,Negrete AC,Cabrales P,Díaz JS,Intaglietta M

    更新日期：2008-01-01 00:00:00

  • Parametric imaging with contrast-enhanced ultrasound: usefulness for characterization of dynamic effects of microvascularization for hepatocellular carcinoma and focal nodular hyperplasia.

    abstract：OBJECTIVE:To evaluate whether parametric imaging with contrast-enhanced ultrasound (CEUS) is equal to experienced radiologists after review of CEUS in differentiating hepatocellular carcinoma (HCC) from focal nodular hyperplasia (FNH). METHODS:An image processing software was used to quantitatively analyze the CEUS cl...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-121652

    authors： Zheng SG,Xu HX,Liu LN,Wang Y,Zhang YF,Guo LH,Liu C,Xu JM,Sun LP,Wu J

    更新日期：2013-01-01 00:00:00

  • Vascular complications in liver transplantation: Beneficial role of contrast-enhanced ultrasound (CEUS) in the postoperative phase.

    abstract：PURPOSE:To compare the sensitivity and specificity of contrast-enhanced ultrasound (CEUS) and computed tomography (CT) in the diagnosis of vascular complications after liver transplantation in the postoperative phase. MATERIALS AND METHODS:A total of 60 patients with elevated liver function tests after liver transplan...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：10.3233/CH-168118

    authors： Rübenthaler J,Paprottka KJ,Hameister E,Hoffmann K,Joiko N,Reiser M,Clevert DA

    更新日期：2016-01-01 00:00:00

  • Oxidative stress and hemorheological changes induced by acute treadmill exercise.

    abstract：:The present investigation was designed to evaluate the acute effect of aerobic exercise on oxidative stress and the flow properties of the blood. Fourteen clinically healthy subjects (7 men and 7 women aged 56+/-19 yr) underwent maximal treadmill exercise with blood samples drawn prior to and immediately after exercis...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Ajmani RS,Fleg JL,Demehin AA,Wright JG,O'Connor F,Heim JM,Tarien E,Rifkind JM

    更新日期：2003-01-01 00:00:00

  • Studies on the aggregation behaviour of pegylated human red blood cells with the Zeta sedimentation technique.

    abstract：:Covalent binding of poly(ethylene glycol), abbreviated as PEG, to red blood cells (RBC) surface leads to masking of the RBC blood group determinants and the PEG layer on the cell surface sterically hinders RBC-RBC and RBC-plasma protein interactions. We cross-linked linear mPEG-SPA of various molecular mass (2000, 500...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Jovtchev S,Stoeff S,Arnold K,Zschörnig O

    更新日期：2008-01-01 00:00:00

  • Discussion on the relationship between normal hematocrit and geographical factors in China.

    abstract：:This paper is written in order to provide a scientific basis for laying out an unified standard of the reference value of hematocrit of Chinese healthy people. It studies the relationship between the reference values of Chinese adults' hematocrit, tested according to the Wintrobe Laws and five geographical factors. It...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Miao G,Yan Y,Chuanmin Z,Naiying L

    更新日期：1997-11-01 00:00:00

  • Microvascular vasodilatory responses to electric acupuncture in rat brain under acute hemorrhagic hypotension.

    abstract：:The present experiment attempted to evaluate the effect of electrical acupuncture on the cerebral microcirculation in anesthetized rats, using fluorescence videomicroscopy. Changes in the pial arteriolar diameter under acute hemorrhagic hypotension were examined quantitatively. The present results suggest that acupunc...

    journal_title：Clinical hemorheology and microcirculation

    pub_type： 杂志文章

    doi：

    authors： Niimi H,Yamaguchi S,Hu QH,Zhuang FY

    更新日期：2000-01-01 00:00:00