Abstract：
:In this study we determine the effects of reducing blood glucose on mean arterial blood pressure (MAP) and hematocrit (Hct) in patients with type 2 diabetes who are not responding to conventional treatment in an intensive treatment program 1 year after initiation of treatment. Data on MAP, glucose and Hct was obtained from 21 diabetic type 2 individuals subjected to personalized treatment and compared (paired statistics) to pretreatment conditions. Exclusion criteria were severe retinopathy, diabetic nephropathy, amputation of diabetic foot and increased glucose>50 mg/dl. Treatment was the combined administration of glibenclamide and metformin dosed to obtain a reduction of glucose levels. Exercise and strict adherence to a prescribed diet were prescribed in all cases. One year after initiation of therapy, glucose decreased from 219 +/- 87 to 158+/-51 mg/dl (p<0.002), Hct increased from 41.6 +/- 3.2 to 44.7+/-2.9% (p<0.001) and MAP decreased from 100.6 +/- 11.0 to 94.3+/-7.2 mmHg (p<0.001). There were no statically significant changes in cholesterol and triglyceride concentrations. The patients lost weight (72.5+/-12.6 to 70.3+/-13.0 kg, p<0.001) and lowered blood creatinine concentration from 1.04+/-0.24 to 0.95+/-0.25 mg/dl, p<0.05. The increase in Hct should correspond to an increase in blood viscosity of about 12%, however blood pressure, and presumably vascular resistance, decreased by 6%. It is proposed that these effects are in part related to improved kidney function resulting in increased Hct and blood viscosity which increases vascular wall shear stress and NO bioavailability leading to a vasodilator effect.
journal_name
Clin Hemorheol Microcircjournal_title
Clinical hemorheology and microcirculationauthors
Salazar Vázquez BY,Salazar Vázquez MA,Venzor VC,Negrete AC,Cabrales P,Díaz JS,Intaglietta Msubject
Has Abstractpub_date
2008-01-01 00:00:00pages
57-64issue
1eissn
1386-0291issn
1875-8622journal_volume
38pub_type
临床试验,杂志文章abstract：BACKGROUND:Plasma cell mastitis (PCM), a common type of mastitis often mimics malignancy clinically and radiologically. OBJECTIVE:The study was designed to explore the diagnostic value of superb microvascular imaging (SMI) in differentiating PCM from malignant breast lesions. METHODS:A total of 95 breast lesions unde...
journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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doi：
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journal_title：Clinical hemorheology and microcirculation
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