Abstract：
:Hypothyroidism is associated with atherosclerotic events, however, the mechanism is unclear. We investigated the effects of oxidative stress and cholesterol on plasma viscosity in female patients with hypothyroidism (n = 20; mean age: 45.5 +/- 5.5 years) at baseline and after L-thyroxine replacement therapy (average daily dose being 0.1 to 0.15 mg). Two blood samples were taken after 2.3 +/- 1.2 months. In hypothyroid state plasma viscosity and thiobarbituric acid reactive substance (TBARS; marker of oxidative stress were significantly higher (p < 0.001 and p < 0.001), and plasma protein thiol (antioxidants) levels were significantly lower (p < 0.001) than in the healthy state (female; n = 15). After L-thyroxine replacement therapy, patients reached to euthyroid state. In this state, the levels of plasma viscosity and TBARS were decreased (p < 0.001 and p < 0.001), and protein thiol levels were significantly elevated (p < 0.001). There was a significant correlation between plasma cholesterol and viscosity (r = 0.64, p < 0.001), as well as plasma protein thiol (r = -0.59, p < 0.001) in the patients. The correlation between viscosity and TBARS was weak (r = 0.29, p < 0.01). Therefore hypothyroidism may be associated with atherosclerotic process by different mechanisms.
journal_name
Clin Hemorheol Microcircjournal_title
Clinical hemorheology and microcirculationauthors
Konukoglu D,Ercan M,Hatemi Hsubject
Has Abstractpub_date
2002-01-01 00:00:00pages
107-13issue
2eissn
1386-0291issn
1875-8622journal_volume
27pub_type
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journal_title：Clinical hemorheology and microcirculation
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更新日期：2020-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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doi：
更新日期：2002-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
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doi：
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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doi：
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journal_title：Clinical hemorheology and microcirculation
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doi：
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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更新日期：2015-01-01 00:00:00
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pub_type： 杂志文章,多中心研究
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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