Abstract：
:It is now clear that different pathophysiologic mechanisms have a profound influence on the extent of the functional impairment in intermittent claudication. In particular, metabolic derangements, including impaired oxygen delivery and/or extraction, reduced nitric oxide synthesis, reduced glucose oxidation, accumulation of toxic metabolites and reduction in carnitine availability are correlated with disease severity. Therefore, metabolic interventions aimed at counteracting these alterations may represent a valid therapeutic approach to the treatment of this condition. To date, verapamil and L-arginine efficacy has been proven in few patients; a large scale clinical trial, conversely, reports that propionyl-L-carnitine appears to be an effective and well tolerated drug for the treatment of intermittent claudication.
journal_name
Clin Hemorheol Microcircjournal_title
Clinical hemorheology and microcirculationauthors
Brevetti G,Corrado S,Martone VD,Di Donato A,Silvestro A,Vanni Lsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
245-54issue
3-4eissn
1386-0291issn
1875-8622journal_volume
21pub_type
杂志文章,评审abstract：:Regular physical activity leads to increased endothelium-dependent vasodilatation. Postocclusive reactive hyperemia (PRH) is a transient increase of blood flow after the release of an arterial occlusion and has been used as a clinical tool to estimate endothelial function. The aim of our study was to assess the potent...
journal_title：Clinical hemorheology and microcirculation
pub_type： 临床试验,杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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doi：
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章,随机对照试验
doi：10.3233/CH-160207
更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
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journal_title：Clinical hemorheology and microcirculation
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doi：
更新日期：2007-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章,多中心研究
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更新日期：2016-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
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doi：10.3233/CH-170336
更新日期：2018-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type：
doi：
更新日期：2002-01-01 00:00:00
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pub_type： 杂志文章
doi：10.3233/CH-190582
更新日期：2020-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
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doi：
更新日期：2004-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
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doi：10.3233/CH-15107
更新日期：2017-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
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更新日期：2020-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
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更新日期：2016-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
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doi：
更新日期：2004-01-01 00:00:00
