Abstract：
OBJECTIVE:To assess the severity of renal pathology in patients with chronic kidney disease (CKD) using contrast-enhanced ultrasonography (US). METHODS:275 patients with CKD who were proven by renal biopsy and 30 healthy adults were examined using conventional US and contrast-enhanced US. Ultrasonic parameters included renal length, cortical thickness, rise time (RT), peak intensity (PI), area under the time-intensity curve (AUC), wash-in slope (WIS) and time to peak (TTP). Based on pathological scores, CKD patients were classified into mild, and moderate to severe CKD groups. The logistic regression analysis and receiver operating characteristic (ROC) curves were used. RESULTS:PI and AUC differed significantly among the controls, mild and moderate to severe CKD groups (P < 0.05). There was significant difference in PI among the different pathology types (P < 0.05). The multivariate logistic regression analysis showed that PI was associated independently with the severity of renal pathology in patients with CKD (P < 0.05). PI less than 13.87 dB had a certain diagnostic ability, and the sensitivity and specificity were 72.5% and 64.0%, respectively. CONCLUSIONS:Contrast-enhanced US may be useful for noninvasive assessment of the severity of renal pathology. PI may be potentially valuable for guiding therapy and follow-up in patients with CKD.
journal_name
Clin Hemorheol Microcircjournal_title
Clinical hemorheology and microcirculationauthors
Yang WQ,Mou S,Xu Y,Xu L,Li FH,Li HLdoi
10.3233/CH-170303subject
Has Abstractpub_date
2018-01-01 00:00:00pages
71-82issue
1eissn
1386-0291issn
1875-8622pii
CH170303journal_volume
68pub_type
杂志文章abstract：:Under both the in vivo and in vitro conditions we investigated the insulin effect on the most significant factor disturbing the blood rheological disorders in the microcirculation, the red blood cell aggregability. The in vivo studies we carried out in the 42 insulin treated diabetic patients (diabetes mellitus type I...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Beta-thalassaemia is a hereditary hemolytic disease, in which each clinic phenotype encompasses a heterogenic group of genetic alterations resulting in beta-globin chain synthesis decrease or absence in red blood cells. Studies on beta-thalassaemia carriers suggest the existence of decreased red cell deformability. Th...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Cigarette smoking deteriorates human health via vascular disorders, cancer and especially respiratory diseases. The aim of this study is to investigate effects of cigarette smoking on hemorheologic parameters, plasma osmolality and lung function in individuals without diagnosis of chronic obstructive pulmona...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-152018
更新日期：2016-10-05 00:00:00
abstract：:Red blood cell distribution width (RDW) has been shown to be associated with disease activity in several inflammatory disorders. However only one study to show this has been conducted in patients with Behçet's disease (BD). The aim of the present study was to analyse the association of RDW with BD and its main complic...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-131744
更新日期：2014-01-01 00:00:00
abstract：:Anemia in pregnant women is associated with increased maternal and perinatal mortality and represents an important economic burden in many developing countries. Our goal was to evaluate the impact of anemia on the capillary network during pregnancy. Therefore, we compared microcirculatory parameters of anemic pregnant...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-162064
更新日期：2016-11-25 00:00:00
abstract：:Autologus veins have been used clinically as a bypass conduit for reconstruction of small arteries, but there are few data available for microvascular response to arteriovenous (AV) shunting. This study was aimed to evaluate microvascular hemodynamic changes induced by creating AV anastomosis in rat hindlimb. Using in...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:In the vascular system, the shear applied to the vascular wall activates mechano-sensors located on endothelial cells (ECs) leading to a modification in the gene expression profile. We applied laminar shear stress at 1 Pa on ECs for 6 h and measured by quantitative real time PCR the expression modulation of genes impl...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-190582
更新日期：2020-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-180424
更新日期：2019-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-179212
更新日期：2017-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-2012-1532
更新日期：2012-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-141894
更新日期：2014-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-2010-1275
更新日期：2010-01-01 00:00:00
abstract：:General anesthesia, either with inhalation or through nonvolatile anesthetics, is known to affect the overall cardiovascular function as well as the microcirculatory hemodynamics. In this study, the effects of desfluran anesthesia on the red blood cell deformability of young and old rats are investigated. 33 male rats...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-190671
更新日期：2020-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-151940
更新日期：2015-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-2012-1531
更新日期：2012-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-141866
更新日期：2015-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
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doi：10.3233/CH-190693
更新日期：2020-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章,随机对照试验
doi：10.3233/CH-160207
更新日期：2017-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章,多中心研究
doi：10.3233/CH-151958
更新日期：2016-01-01 00:00:00
abstract：:Accumulated uremic toxins like indoxyl sulphate, hippuric acid and p-cresyl sulphates in renal failure patients stimulate proinflammatory effects, and consequently kidney and cardiovascular diseases. Low clearance rate of these uremic toxins from the blood of uremic patients by conventional techniques like hemodialysi...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-168046
更新日期：2016-01-01 00:00:00
abstract：:There are few studies on haemorheological disturbances in morbidly obese patients. The role played by the metabolic syndrome on the rheological profile of morbidly obese subjects has not yet been established, and it is not clear whether morbidly obese, but "metabolically healthy", show rheological alterations. We aime...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-2011-1417
更新日期：2011-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-16159
更新日期：2017-01-01 00:00:00
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journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-2010-1330
更新日期：2010-01-01 00:00:00
abstract：:This review starts with a brief description of the pioneering work done by J.R. Casley-Smith when he looked at the pathophysiological changes that occur, and transport from the blood vessels, through the interstitium to the lymphatics and lymphatic uptake, with the electron microscope. Collaboration with, and further ...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Atherothrombotic complications are frequent in patients with type 2 diabetes. Red blood cells (RBC) from diabetic patients exhibited an increased adhesion which correlated to the extent of vascular complications. In the present study we have investigated the adhesive interactions of RBCs with endothelium, using flow-b...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:To identify the indications for CEUS in renal imaging in an interdisciplinary ultrasound department. METHODS:102 CEUS examinations of the kidney in 82 patients between September 2014 and July 2016 were analysed regarding the indication for ultrasound. CEUS was performed by one experienced sonographer agent a...
journal_title：Clinical hemorheology and microcirculation
pub_type： 杂志文章
doi：10.3233/CH-179103
更新日期：2017-01-01 00:00:00
