Sex-dependent differences in rheological properties and the relation of blood viscosity to erythrocyte aggregation indices among morbidly obese patients.

Abstract:

:Some studies indicate that obesity is associated with rheological disturbances. Because there are usually sex differences in the type of obesity we decided to evaluate rheological differences between male and female obese patients. We studied 18 morbidly obese men, mean age 43.66 +/- 11.32 years, mean body mass index (BMI) 49.82 +/- 6.03 kg/m2 and 20 obese females, mean age 40.6 +/- 11.86 years, mean BMI 47.41 +/- 8.81 kg/m2. Blood and plasma viscosity measurements were performed using a cone-plate viscometer (Brookfield DV-II). Erythrocyte elongation and red blood cell (RBC) aggregation were measured using the Laser-assisted Optical Rotational Cell Analyser (LORCA). Whole blood viscosity and RBC deformability expressed by the elongation index were significantly higher in obese men. We did not observe differences in plasma viscosity, corrected blood viscosity and aggregation parameters among the obese population. Blood viscosity correlated with selected RBC aggregation indices. We conclude that morbidly obese patients presented sex-dependent differences in some rheological properties. This study indicates a relation between erythrocyte aggregation indices and blood viscosity in obese populations.

authors

Wiewióra M,Sosada K,Slowinska L,Piecuch J,Glück M,Zurawinski W,Turczynski B

doi

10.3233/CH-2010-1275

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

259-67

issue

4

eissn

1386-0291

issn

1875-8622

pii

3014VM4684001632

journal_volume

44

pub_type

杂志文章
  • Astroglial swelling for removed rat brain enlargement incubated in deoxygenated mock cerebrospinal fluid.

    abstract::The source and target of edema fluid for ischemic brain swelling clinically often observed in "malignant infarction" was examined in ex vivo. Wister rat brain hemispheres were removed and incubated air-tightly in a deoxygenated artificial cerebrospinal fluid at 37 degrees for 30 min. Ionic movement into the brain tiss...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Osada T,Tomita M,Tanahashi N,Takeda H,Nagai T,Suzuki N

    更新日期:2006-01-01 00:00:00

  • Influence of nanoporous poly(ether imide) particle extracts on human aortic endothelial cells (HAECs).

    abstract::Accumulated uremic toxins like indoxyl sulphate, hippuric acid and p-cresyl sulphates in renal failure patients stimulate proinflammatory effects, and consequently kidney and cardiovascular diseases. Low clearance rate of these uremic toxins from the blood of uremic patients by conventional techniques like hemodialysi...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-168046

    authors: Kumar RK,Basu S,Lemke HD,Jankowski J,Kratz K,Lendlein A,Tetali SD

    更新日期:2016-01-01 00:00:00

  • Physostigmine reverses disturbances of the intestinal microcirculation during experimental endotoxemia.

    abstract::Intestinal microcirculatory disturbances play an important role in the pathophysiology of sepsis. A neural anti-inflammatory pathway has been suggested as a potential target for therapy that may dampen systemic inflammation. The aim of this study is to investigate the effects of physostigmine, a cholinesterase inhibit...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-131743

    authors: Zhou J,Pavlovic D,Rüb J,Masur S,Spassov A,Whynot S,Hung O,Kern H,Saleh Abdo I,Shukla R,Cerny V,Lehmann C

    更新日期:2014-01-01 00:00:00

  • Plasma viscosity in female patients with hypothyroidism: effects of oxidative stress and cholesterol.

    abstract::Hypothyroidism is associated with atherosclerotic events, however, the mechanism is unclear. We investigated the effects of oxidative stress and cholesterol on plasma viscosity in female patients with hypothyroidism (n = 20; mean age: 45.5 +/- 5.5 years) at baseline and after L-thyroxine replacement therapy (average d...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Konukoglu D,Ercan M,Hatemi H

    更新日期:2002-01-01 00:00:00

  • Alpha smooth muscle actin in the cycling ovary - an immunohistochemical study.

    abstract::In the ovary with its cyclically developing and regressing functional bodies and the associated intense neovascularisation and remodelling, alpha-smooth muscle actin (SMA) immunolocalisation has been frequently used as a marker to establish vessel hierarchy, in angiogenesis studies, or in studies characterising ovaria...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2011-1448

    authors: Hirschberg RM,Plendl J,Kaessmeyer S

    更新日期:2012-01-01 00:00:00

  • IL-17 predicts the effect of TACE combined with apatinib in hepatocellular carcinoma.

    abstract:OBJECTIVE:IL-17 is considered to be a cancer-promoting gene in hepatocellular carcinoma (HCC). Here, we explored the effect of IL-17 in predicting the therapeutic effect of transcatheter arterial chemoembolization (TACE) combined with apartinib in patients with HCC in this study. METHODS:Established of IL-17 knockdown...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-200857

    authors: Wu Y,Cheng G,Chen H,Wang J,Wang J,Wang W

    更新日期:2020-07-09 00:00:00

  • The role of erythrocytapheresis in secondary erythrocytosis therapy.

    abstract::In chronic respiratory insufficiency secondary erythrocytosis (SPC), causing pulmonary hypertension and dx ventricular insufficiency, is often noticed. An alternative therapy to phlebotomy for SPC is isovolemic large volume erythrocytapheresis performed with cell separator (CSE) in order to quickly remove a large volu...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Pollari G,Antonini V,Izzo A,Moreschini G,Serraino M,Tonelli V,D'Angiolino A,Migliaccio M

    更新日期:1999-01-01 00:00:00

  • Evidence for cytostatic effect of cyclophosphamide on human vein endothelial cells in cancer therapy: Preliminary in vitro results.

    abstract::In cancer therapy, a number of drugs with different mechanisms of action are in clinical use, which act directly after administration without metabolism, while others only become active in the metabolites produced in the liver. Such drugs/metabolites - especially when administered parenterally - interact in high conce...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-189125

    authors: Krüger-Genge A,Steinbrecht S,Küpper JH,Lendlein A,Jung F

    更新日期:2018-01-01 00:00:00

  • Laparoscopy-guided percutaneous microwave ablation for symptomatic 12.8 cm hepatic hemangioma with low blood loss and short hospital stay post-operation: A case report and literature review.

    abstract::We described a patient with symptomatic giant hepatic hemangioma (GHH) treated with laparoscopic guided percutaneous microwave ablation (MWA). A 58 years' old woman was referred to our hospital who presented with upper abdominal distension and appetite loss for more than 1 year. The medical history included untreated ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-200922

    authors: Zhang HL,Meng HB,Li XL,Sun LP,Lu F,Xu HX,Yu SY

    更新日期:2020-10-13 00:00:00

  • Metabolic alterations in morbid obesity. Influence on the haemorheological profile.

    abstract::There are few studies on haemorheological disturbances in morbidly obese patients. The role played by the metabolic syndrome on the rheological profile of morbidly obese subjects has not yet been established, and it is not clear whether morbidly obese, but "metabolically healthy", show rheological alterations. We aime...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2011-1417

    authors: Vayá A,Hernández-Mijares A,Suescun M,Solá E,Cámara R,Romagnoli M,Bautista D,Laiz B

    更新日期:2011-01-01 00:00:00

  • The role of GST polymorphism in reperfusion induced oxidative stress, inflammatory responses and clinical complications after surgical and percutaneous coronary intervention.

    abstract:BACKGROUND:Patients having coronary artery disease treated by coronary bypass or PCI procedure are exposed to tissue damage because of the phenomenon called reperfusion injury. Reperfusion injury can be characterized/monitored by oxidative stress parameters, inflammatory markers and by post-operative complication rate....

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/CH-170270

    authors: Pintér Ö,Hardi P,Nagy T,Gasz B,Kovács V,Arató E,Sínay L,Lénárd L,Jancsó G

    更新日期:2017-01-01 00:00:00

  • Impaired blood rheology by remnant-like lipoprotein particles: studies in patients with fatty liver disease.

    abstract::Fatty liver disease (FLD) characterised by a high plasma levels of lipoproteins and remnant-like lipoproteins (RLP) is a risk factor for impaired microvascular blood flow, endothelial cell dysfunction and atherosclerosis. Using an immunoseparation technique with a gel mixture containing human monoclonal antibodies to ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Kurihara T,Deguchi S,Kato J,Furakawa M,Tsuchiya M,Akimoto M,Ishiguro H,Hashimoto H,Niimi A,Maeda A,Shigemoto M,Yamashita K,Kawakami A,Umemura K,Nakashima M,Nakano T,Saniabadi AR

    更新日期:2001-01-01 00:00:00

  • Modulating human mesenchymal stem cells using poly(n-butyl acrylate) networks in vitro with elasticity matching human arteries.

    abstract::Non-swelling hydrophobic poly(n-butyl acrylate) network (cPnBA) is a candidate material for synthetic vascular grafts owing to its low toxicity and tailorable mechanical properties. Mesenchymal stem cells (MSCs) are an attractive cell type for accelerating endothelialization because of their superior anti-thrombosis a...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-189418

    authors: Wang W,Xu X,Li Z,Kratz K,Ma N,Lendlein A

    更新日期:2019-01-01 00:00:00

  • Association of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage: the J-SHIP and Toon Health Study.

    abstract:BACKGROUND:Elevated hematocrit levels have been suggested to be an independent determinant of insulin resistance and type 2 diabetes. To clarify the diagnostic significance of hematocrit level, we investigated the association with hemodynamic profiles, insulin resistance and insulin sensitivity, arterial properties, an...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2012-1634

    authors: Tabara Y,Igase M,Saito I,Nishida W,Kohara K,Sakurai S,Kawamura R,Okada Y,Hitsumoto S,Onuma H,Nagai T,Takata Y,Uetani E,Takita R,Kido T,Ochi N,Osawa H,Tanigawa T,Miki T

    更新日期:2013-01-01 00:00:00

  • Possible involvement of oxidative stress in exercise-mediated platelet activation.

    abstract::In this study, we have attempted to verify whether a single bout of strenuous exercise performed by sedentary healthy individuals may interfere with the mechanisms controlling platelet sensitivity through exercise-related modifications of plasma oxidant/antioxidant equilibrium. Strenuous exercise resulted in an increa...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Di Massimo C,Scarpelli P,Tozzi-Ciancarelli MG

    更新日期:2004-01-01 00:00:00

  • Chronic liver disease: Correlation of CEUS-based microperfusion and indocyanine green clearance.

    abstract:PURPOSE:To evaluate whether changes of dynamic contrast-enhanced ultrasound (CEUS)-based liver microcirculation during chronic liver disease are correlated with the extent of impaired liver function, expressed by the indocyanine green (ICG) clearance. MATERIALS AND METHODS:19 patients underwent CEUS examinations with ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-151990

    authors: Haimerl M,Jung EM,Beyer LP,Pregler B,Dollinger M,Sieroń D,Niessen C,Stroszczynski C,Wiggermann P

    更新日期:2015-01-01 00:00:00

  • Sex-related differences in forearm skin microvascular reactivity of young healthy subjects.

    abstract:OBJECTIVE:To assess sex-related differences in forearm skin microvascular reactivity to vascular occlusion and cardiovascular health in young healthy women and men. METHODS:203 young healthy individuals (67 men/136 women) participated in this study. Post-occlusive reactive hyperemia (PORH) in skin microcirculation fol...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-180483

    authors: Stupin A,Stupin M,Baric L,Matic A,Kolar L,Drenjancevic I

    更新日期:2019-01-01 00:00:00

  • Performance evaluation of the Anysis-200 platelet function analyzer in cardiac patients.

    abstract:BACKGROUND:Platelet function analysis is crucial in assessing the hemostatic status to evaluate congenital and acquired platelet function defects. The Anysis-200 analyzer is a new automated lab-on-a-chip-based platelet function analyzer. OBJECTIVE:We aimed to evaluate a new platelet function analyzing system, the Anys...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-190801

    authors: Park SJ,Yoon J,Seo HS,Lim CS

    更新日期:2020-02-24 00:00:00

  • Susceptibility of erythrocytes from non-insulin-dependent diabetes mellitus and hemodialysis patients, cigarette smokers and normal subjects to in vitro oxidative stress and loss of deformability.

    abstract::Incubation of normal erythrocytes with 10 mM H2O2 has caused a loss of deformability. This loss of deformability was correlated with the extent of malonyldialdehyde, MDA (an indicator of lipid peroxidation) and alanine production (an indicator of protein degradation). The susceptibility of erythrocytes from 21 non-ins...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Srour MA,Bilto YY,Juma M

    更新日期:2000-01-01 00:00:00

  • Altitude training induced alterations in erythrocyte rheological properties: a controlled comparison study in rats.

    abstract::Altitude training is frequently used by athletes to improve sea-level performance. However, the objective benefits of altitude training are controversial. This study aimed to investigate the possible alterations in hemorheological parameters in response to altitude training. Sprague Dawley rats, were divided into 6 gr...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-131711

    authors: Bor-Kucukatay M,Colak R,Erken G,Kilic-Toprak E,Kucukatay V

    更新日期:2014-01-01 00:00:00

  • Endothelial nitric oxide synthase expression in systemic and pulmonary circulation of streptozotocin induced diabetic rats: comparison using image analysis.

    abstract::To compare the level of endothelial nitric oxide synthase (eNOS) expression produced in heart and lung vascular tissue, the protein content was determined using Western blot analysis with the enhancement of image processing. Heart and lung extracts from 12 and 24 weeks from control (CON) and streptozotocin-induced dia...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Sridulyakul P,Chakraphan D,Bhattarakosol P,Patumraj S

    更新日期:2003-01-01 00:00:00

  • Hemorheology and heart rate variability: is there a relationship?

    abstract::The aim of the present study was to test the relationships between hemorheology and autonomic nervous system (ANS) activity in 23 sickle cell trait (SCT) carriers and 17 control subjects. Hemorheological parameters were assessed at rest. Nocturnal ANS activity was calculated from heart rate variability indices. Impair...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Connes P,Hue O,Hardy-Dessources MD,Boucher JH,Pichot V,Barthélémy JC

    更新日期:2008-01-01 00:00:00

  • Current approaches to non-invasive optical oximetry.

    abstract::The optical oxymetry methods based on light transmission or diffuse reflectance of living tissues are discussed. The experimental techniques now under test are highlighted. ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,评审

    doi:

    authors: Lugarà PM

    更新日期:1999-01-01 00:00:00

  • Use of contrast-enhanced ultrasound to monitor rabbit renal ischemia-reperfusion injury and correlations between time-intensity curve parameters and renal ICAM-1 expression.

    abstract:BACKGROUND:Renal ischemia-reperfusion injury (IRI) is common in renal transplantation, shock, and nephrolithotomy. OBJECTIVE:To quantitatively assess rabbit renal IRI with contrast-enhanced ultrasound (CEUS) and investigate associations between renal cortical time-intensity curve (TIC) parameters and intracellular adh...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-131768

    authors: Li M,Luo Z,Chen X,Xuan J,Ye F,Liu H,Chen K

    更新日期:2015-01-01 00:00:00

  • Effects of nimodipine combined with betahistine on CRP and other inflammatory cytokines and vascular endothelial function in patients with hypertensive cerebral vasospasm.

    abstract:OBJECTIVE:This study aims to investigate the effect of nimodipine combined with betahistine on the levels of CRP and other inflammatory cytokines, as well as vascular endothelial function in patients with hypertensive cerebral vasospasm. METHODS:A total of 80 patients with hypertensive cerebral vasospasm from March 20...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-190589

    authors: Liu X,Zhao N,Zeng K,Xiao P,Sheng P,Luo X,Wang Y

    更新日期:2020-01-01 00:00:00

  • The knockout of urea transporter-B improves the hemorheological properties of erythrocyte.

    abstract:OBJECTIVE:Urea transporter-B (UT-B), highly expressed in erythrocyte, confers specific permeability to urea, urea analogues and water. The purpose of this study was to determine the hemorheological properties of UT-B null erythrocyte using a series of biophysical techniques. METHODS AND RESULTS:The blood was taken fro...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-16174

    authors: Geng X,Lei T,Zhou H,Yao W,Xin W,Yang B

    更新日期:2017-01-01 00:00:00

  • A long-distance fluid transport pathway within fibrous connective tissues in patients with ankle edema.

    abstract:OBJECTIVES:Although the microcirculatory dysfunctions of edema formation are well documented, the draining pattern of dermal edema lacks information. This study was to assess the potential drainage pathways of the interstitial fluid in patients with ankle edema using the anatomical and histological methods. METHODS AN...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-162057

    authors: Li H,Yang C,Lu K,Zhang L,Yang J,Wang F,Liu D,Cui D,Sun M,Pang J,Dai L,Han D,Liao F

    更新日期:2016-10-05 00:00:00

  • The red blood cell deformability alterations under desfluran anesthesia in rats.

    abstract::General anesthesia, either with inhalation or through nonvolatile anesthetics, is known to affect the overall cardiovascular function as well as the microcirculatory hemodynamics. In this study, the effects of desfluran anesthesia on the red blood cell deformability of young and old rats are investigated. 33 male rats...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Yerer MB,Aydoğan S,Comu FM,Arslan M,Güneş-Ekinci I,Kurtipek O,Unal Y

    更新日期:2006-01-01 00:00:00

  • Elevated plasma nitric oxide metabolites in hypertension: synergistic vasodepressor effects of a static magnetic field and nicardipine in spontaneously hypertensive rats.

    abstract::The involvement of plasma nitric oxide metabolites (NO(x)) in hypertension was examined in stroke-resistant spontaneously hypertensive rats during the development of hypertension. Continuous application of a static magnetic field (SMF; a maximum magnetic flux density of 180 millitesla, a peak magnetic gradient of 133 ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Okano H,Ohkubo C

    更新日期:2006-01-01 00:00:00

  • Effect of extracts of poly(ether imide) microparticles on cytotoxicity, ROS generation and proinflammatory effects on human monocytic (THP-1) cells.

    abstract::Current haemodialysis techniques are not capable to remove efficiently low molecular weight hydrophobic uremic toxins from the blood of patients suffering from chronic renal failure. With respect to the hydrophobic characteristics and the high level of protein binding of these uremic toxins, hydrophobic adsorber mater...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-152027

    authors: Kumar RK,Basu S,Lemke HD,Jankowski J,Kratz K,Lendlein A,Tetali SD

    更新日期:2016-01-01 00:00:00