Abstract:
BACKGROUND:Reduced availability of nitric oxide leads to dysfunction of endothelium which plays an important role in the development of cardiovascular diseases. OBJECTIVE:The aim of the present study was to determine whether the dietary supplement L-arginine improves the endothelial function of microvessels by increasing nitric oxide production. METHODS:We undertook experiments on 51 healthy male volunteers, divided into 4 groups based on their age and physical activity since regular physical activity itself increases endothelium-dependent vasodilation. The skin laser Doppler flux was measured in the microvessels before and after the ingestion of L-arginine (0.9 g). The endothelium-dependent vasodilation was assessed by acetylcholine iontophoresis and the endothelium-independent vasodilation by sodium nitroprusside iontophoresis. In addition, we measured endothelium-dependent and endothelium-independent vasodilation in 81 healthy subjects divided into four age groups. RESULTS:After the ingestion of L-arginine, the endothelium-dependent vasodilation in the young trained subjects increased (paired t-test, p < 0.05), while in the other groups it remained the same. There were no differences in the endothelium-independent vasodilation after ingestion of L-arginine. With aging endothelium-independent vasodilation decreased while endothelium-dependent vasodilation remained mainly unchanged. CONCLUSION:Obtained results demonstrated that a single dose of L-arginine influences endothelium-dependent vasodilation predominantly in young, trained individuals.
journal_name
Clin Hemorheol Microcircjournal_title
Clinical hemorheology and microcirculationauthors
Melik Z,Zaletel P,Virtic T,Cankar Kdoi
10.3233/CH-16159subject
Has Abstractpub_date
2017-01-01 00:00:00pages
205-217issue
3eissn
1386-0291issn
1875-8622pii
CH16159journal_volume
65pub_type
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journal_title:Clinical hemorheology and microcirculation
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journal_title:Clinical hemorheology and microcirculation
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journal_title:Clinical hemorheology and microcirculation
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journal_title:Clinical hemorheology and microcirculation
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journal_title:Clinical hemorheology and microcirculation
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doi:10.3233/CH-190723
更新日期:2020-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
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doi:10.3233/CH-131734
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doi:10.3233/CH-152001
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:
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journal_title:Clinical hemorheology and microcirculation
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doi:
更新日期:2006-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
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doi:10.3233/CH-151940
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journal_title:Clinical hemorheology and microcirculation
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doi:10.3233/CH-209216
更新日期:2020-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:
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journal_title:Clinical hemorheology and microcirculation
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doi:10.3233/CH-2011-1459
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章,评审
doi:
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
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更新日期:2016-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
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doi:10.3233/CH-141843
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
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