Erythrocyte osmotic fragility increases with serum advanced glycated end products in cigarette smokers.

Abstract:

BACKGROUND:This study examines the relationship between circulating advanced glycated end products (AGEs) level and erythrocyte osmotic fragility in smokers. METHODS:Forty-eight smokers (aged 45 ± 5 years) and fifty healthy nonsmokers (aged 42 ± 6 years) were selected in this study. All subjects were analysed according to serum AGEs, osmotic fragility (H50, the NaCL concentration producing 50% hemolysis), malondialdehyde (MDA) and advanced oxidation protein products (AOPP). RESULTS:The data show that the serum AGEs, H50, MDA and AOPP levels were significantly higher for smokers than that of nonsmokers (p < 0.01). The serum AGEs correlated with H50 in smokers (r = 0.7703, p < 0.01). MDA levels correlated with H50 in smokers (r = 0.7584, p < 0.01). CONCLUSIONS:This study demonstrated that serum AGEs and MDA levels positively correlated with osmotic fragility in smokers.

authors

Li R,Chen X

doi

10.3233/CH-131801

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

85-92

issue

1

eissn

1386-0291

issn

1875-8622

pii

L3U28814483677J2

journal_volume

57

pub_type

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