Abstract:
:Rheological findings in essential hypertension are increases in haematocrit, plasma fibrinogen, plasma and whole blood viscosity, and erythrocyte aggregability as well as impaired erythrocyte deformability. Are these abnormalities secondary effects of an increased blood pressure via an increased filtration pressure rendering haemoconcentration or is the initial pressure-increase the result of a deterioration of any of the rheologic variables? Since the diameter of the red cell is about 8.5 microm, and that of the smallest capillaries about 3 microm, the ability of the cell to deform is of vital importance for capillary flow, and a decreased erythrocyte deformability could cause an increased microvascular flow resistance. We found a negative correlation between erythrocyte deformability and fasting insulin and also a decreased erythrocyte deformability in hypertensive patients during a 2 h euglycaemic insulin clamp. Associations between increased intracellular Ca2+ and decreased erythrocyte deformability on one hand and between in vitro insulin and an accumulation of Ca2+ in red blood cells on the other have earlier been shown. Hence, a decreased insulin sensitivity might be one important factor in the development of hypertension acting via an impaired erythrocyte deformability and an increased flow resistance in the microcirculation.
journal_name
Clin Hemorheol Microcircjournal_title
Clinical hemorheology and microcirculationauthors
Sandhagen Bsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
179-81issue
3-4eissn
1386-0291issn
1875-8622journal_volume
21pub_type
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章,随机对照试验
doi:10.3233/CH-180429
更新日期:2019-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
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journal_title:Clinical hemorheology and microcirculation
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:10.3233/CH-2012-1614
更新日期:2012-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:10.3233/CH-2010-1275
更新日期:2010-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:10.3233/CH-2012-1626
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journal_title:Clinical hemorheology and microcirculation
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journal_title:Clinical hemorheology and microcirculation
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更新日期:2020-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:10.3233/CH-141896
更新日期:2014-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:10.3233/CH-200996
更新日期:2021-01-13 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:10.3233/CH-162064
更新日期:2016-11-25 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:10.3233/CH-2011-1509
更新日期:2012-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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journal_title:Clinical hemorheology and microcirculation
pub_type: 杂志文章
doi:10.3233/CH-2010-1326
更新日期:2010-01-01 00:00:00