Red cell fluidity in hypertension.

Abstract:

:Rheological findings in essential hypertension are increases in haematocrit, plasma fibrinogen, plasma and whole blood viscosity, and erythrocyte aggregability as well as impaired erythrocyte deformability. Are these abnormalities secondary effects of an increased blood pressure via an increased filtration pressure rendering haemoconcentration or is the initial pressure-increase the result of a deterioration of any of the rheologic variables? Since the diameter of the red cell is about 8.5 microm, and that of the smallest capillaries about 3 microm, the ability of the cell to deform is of vital importance for capillary flow, and a decreased erythrocyte deformability could cause an increased microvascular flow resistance. We found a negative correlation between erythrocyte deformability and fasting insulin and also a decreased erythrocyte deformability in hypertensive patients during a 2 h euglycaemic insulin clamp. Associations between increased intracellular Ca2+ and decreased erythrocyte deformability on one hand and between in vitro insulin and an accumulation of Ca2+ in red blood cells on the other have earlier been shown. Hence, a decreased insulin sensitivity might be one important factor in the development of hypertension acting via an impaired erythrocyte deformability and an increased flow resistance in the microcirculation.

authors

Sandhagen B

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

179-81

issue

3-4

eissn

1386-0291

issn

1875-8622

journal_volume

21

pub_type

杂志文章,评审
  • Timing of clopidogrel loading dose on peripheral blood endothelial progenitor cells, SDF-1α and neointimal hyperplasia in carotid stenting.

    abstract:BACKGROUND:Carotid stenting stimulates intimal proliferation through platelet and stem cell activation. OBJECTIVE:The aim of this study is to evaluate whether the administration before or after carotid stenting of clopidogrel loading dose may play a role on circulating endothelial progenitor cells, stromal cell-derive...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/CH-180429

    authors: Di Stolfo G,Mastroianno S,Ruggieri M,Fontana A,Marinucci R,Copetti M,Minervini MM,Savino L,Mastroianno M,Savino M,Pacilli MA,Di Mauro L,Potenza DR,Cascavilla N,Paroni G,Russo A

    更新日期:2019-01-01 00:00:00

  • Phototherapy decreases red blood cell deformability in patients with psoriasis.

    abstract:BACKGROUND:Alternations in erythrocyte deformability (ED), namley, the ability of erythrocytes to change shape under flow in the microcirculation, can contribute to cardiovascular diseases. Psoriasis, a systemic inflammatory skin disorder, is associated with an increased cardiovascular risk. The effect of psoriasis and...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-180424

    authors: Biran R,Hadayer N,Ramot Y,Zlotogorski A,Yedgar S,Barshtein G

    更新日期:2019-01-01 00:00:00

  • Endothelial nitric oxide synthase expression in systemic and pulmonary circulation of streptozotocin induced diabetic rats: comparison using image analysis.

    abstract::To compare the level of endothelial nitric oxide synthase (eNOS) expression produced in heart and lung vascular tissue, the protein content was determined using Western blot analysis with the enhancement of image processing. Heart and lung extracts from 12 and 24 weeks from control (CON) and streptozotocin-induced dia...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Sridulyakul P,Chakraphan D,Bhattarakosol P,Patumraj S

    更新日期:2003-01-01 00:00:00

  • Effect of cytochrome P450-dependent epoxyeicosanoids on Ristocetin-induced thrombocyte aggregation.

    abstract::Epoxyeicosatrienoic acids (EETs) produced by cytochrome P450 (CYP)-dependent epoxidation of arachidonic acid (AA) inhibit thrombocyte adhesion to the vascular wall. Upon dietary omega-3 fatty acid supplementation, EETs are partially replaced by eicosapentaenoic acid (EPA)-derived epoxyeicosatetraenoic acids (EEQs) and...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2012-1614

    authors: Jung F,Schulz C,Blaschke F,Muller DN,Mrowietz C,Franke RP,Lendlein A,Schunck WH

    更新日期:2012-01-01 00:00:00

  • Contrast-enhanced ultrasonography (CEUS) using early dynamic in microcirculation for localization of pathological parathyroid glands: first-line or complimentary diagnostic modality?

    abstract:BACKGROUND:Contrast-enhanced ultrasonography (CEUS) represents a new diagnostic tool to localize pathological parathyroid glands. The aim of this study was to differentiate the capability of CEUS as first-line or complimentary modality for the detection of hyperfunctioning parathyroid glands. METHODS:Sixty patients wi...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2011-1459

    authors: Hornung M,Jung EM,Stroszczynski C,Schlitt HJ,Agha A

    更新日期:2011-01-01 00:00:00

  • Sex-dependent differences in rheological properties and the relation of blood viscosity to erythrocyte aggregation indices among morbidly obese patients.

    abstract::Some studies indicate that obesity is associated with rheological disturbances. Because there are usually sex differences in the type of obesity we decided to evaluate rheological differences between male and female obese patients. We studied 18 morbidly obese men, mean age 43.66 +/- 11.32 years, mean body mass index ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2010-1275

    authors: Wiewióra M,Sosada K,Slowinska L,Piecuch J,Glück M,Zurawinski W,Turczynski B

    更新日期:2010-01-01 00:00:00

  • Elevated plasma nitric oxide metabolites in hypertension: synergistic vasodepressor effects of a static magnetic field and nicardipine in spontaneously hypertensive rats.

    abstract::The involvement of plasma nitric oxide metabolites (NO(x)) in hypertension was examined in stroke-resistant spontaneously hypertensive rats during the development of hypertension. Continuous application of a static magnetic field (SMF; a maximum magnetic flux density of 180 millitesla, a peak magnetic gradient of 133 ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Okano H,Ohkubo C

    更新日期:2006-01-01 00:00:00

  • The influence of calcium ions and ionophore A23187 on microrheological characteristics of erythrocytes by new model ektacytometry.

    abstract::After rabbit's erythrocytes were treated with different concentrations of intercellular Ca2+ and ionophore A23187 respectively, the orientation index (DI)or, and small deformation index (DI)d of rabbit erythrocytes were measured by new model ektacytometry. The results demonstrated that (DI)or and (DI)d decreased while...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Chunyi W,Yanjun Z,Weibo K

    更新日期:2001-01-01 00:00:00

  • Effects of radiation on the expression of adhesion molecules and cytokines in a static model of human dermal microvascular endothelial cells.

    abstract:BACKGROUND:Radiation-induced wound healing complications represent an important clinical problem. Microvascular compromise is an important component of its pathogenesis and the microvascular endothelial cell is the key representative affected at the cellular level. MATERIAL AND METHODS:Human dermal microvascular endot...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2012-1626

    authors: Haubner F,Ohmann E,Pohl F,Prantl L,Strutz J,Gassner HG

    更新日期:2013-01-01 00:00:00

  • The low-dose combination preparation Vertigoheel activates cyclic nucleotide pathways and stimulates vasorelaxation.

    abstract::Vertigo of various and often unknown aetiologies has been associated with and attributed to impaired microvascular perfusion in the inner ear or the vertebrobasilar system. Vertigoheel is a low-dose combination preparation of proven value in the symptomatic treatment of vertigo. In the present study we tested the hypo...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2010-1330

    authors: Heinle H,Tober C,Zhang D,Jäggi R,Kuebler WM

    更新日期:2010-01-01 00:00:00

  • Partially cystic thyroid nodules on ultrasound: The associated factors for malignancy.

    abstract:OBJECTIVES:To identify the associated factors for malignancy in partially cystic thyroid nodules (PCTNs) on ultrasound (US). MATERIALS AND METHODS:This is a retrospective study. 338 PCTNs confirmed by surgery was included in this study. The US features of the nodules were reviewed and their significance in differentia...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-190582

    authors: Shi YZ,Jin Y,Zheng L

    更新日期:2020-01-01 00:00:00

  • A comparative study of the haemorheology of various breeds of dog.

    abstract::Haemorheological parameters in nine breeds of dog were examined. Whole blood viscosity at both high and low shear rates differed significantly between the breeds with a 50% difference between the highest and lowest viscosity at high shear rate and a 140% difference at low shear rate. Athletic breeds (Greyhounds, Deerh...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Bodey AR,Rampling MW

    更新日期:1998-07-01 00:00:00

  • Value of high-resolution contrast-enhanced ultrasound in detection and characterisation of endoleaks after EVAR.

    abstract:PURPOSE:To compare the value of high-resolution contrast-enhanced ultrasound in the detection and characterisation of endoleaks after EVAR. MATERIAL AND METHODS:In this retrospective study, a cohort of 80 patients underwent both standard examination using a curved array 5 MHz transducer and a second examination using ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-141896

    authors: Zimmermann H,D'Anastasi M,Rjosk-Dendorfer D,Helck A,Meimarakis G,Reiser M,Clevert DA

    更新日期:2014-01-01 00:00:00

  • Elevated coronary whole blood viscosity in acute coronary syndrome patients.

    abstract:OBJECTIVES:As most clinical studies measure whole blood viscosity (WBV) from peripheral samples, potential differences in WBV obtained from the coronary arteries are often ignored. This study investigated differences in WBV measured from coronary artery specimens in patients with and without acute coronary syndrome (AC...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-131692

    authors: Lee SR,Jung JM,Jung LY,Lee JH,Lee SH,Rhee KS,Chae JK,Kim WH,Ko JK,Lee DH,Rosenson RS

    更新日期:2013-01-01 00:00:00

  • Hemorheology and vascular control mechanisms.

    abstract::Blood rheology is a well-known determinant of tissue perfusion and, according to the Poiseuille relation, hemodynamic resistance in a constant-geometry vascular network is directly proportional to blood viscosity. However, this direct relationship cannot be observed in all in vivo studies. Further, there are several r...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,评审

    doi:

    authors: Baskurt OK,Yalcin O,Meiselman HJ

    更新日期:2004-01-01 00:00:00

  • Metabolic alterations in morbid obesity. Influence on the haemorheological profile.

    abstract::There are few studies on haemorheological disturbances in morbidly obese patients. The role played by the metabolic syndrome on the rheological profile of morbidly obese subjects has not yet been established, and it is not clear whether morbidly obese, but "metabolically healthy", show rheological alterations. We aime...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2011-1417

    authors: Vayá A,Hernández-Mijares A,Suescun M,Solá E,Cámara R,Romagnoli M,Bautista D,Laiz B

    更新日期:2011-01-01 00:00:00

  • Expression of MMPs and TIMPs in primary epithelial cell cultures of the upper aerodigestive tract seeded on the surface of a novel polymeric biomaterial.

    abstract:INTRODUCTION:Using standard cell biological and biochemical experimental approaches we were able to test the ability of a particular polymer construct to support the adhesion, proliferation, and the cellular acitivity of pharyngeal cells. The delicate balance between Matrix Metalloproteinases (MMPs) and their endogenou...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Rickert D,Lendlein A,Kelch S,Moses MA,Franke RP

    更新日期:2005-01-01 00:00:00

  • Comparative evaluation of ballet-type and conventional stent graft configurations for endovascular aneurysm repair: A CFD analysis.

    abstract:PURPOSE:Cross limb stent graft (SG) configuration technique for endovascular aneurysm repair (EVAR) is employed for splayed aortic bifurcations to avoid device kinking and smoothen cannulation. The present study investigates three types of stent graft (SG) configurations for endovascular aneurysm repair (EVAR) in abdom...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-200996

    authors: Ashraf F,Ambreen T,Park CW,Kim DI

    更新日期:2021-01-13 00:00:00

  • Protective effect of tetramethylpyrazine and salvianolic acid B on apoptosis of rat cerebral microvascular endothelial cell under high shear stress.

    abstract::Apoptosis induced by high shear stress has been reported for the dysfunction of various vascular endothelial cells. We investigated the protective effects of tetramethylpyrazine (TMP) and salvianolic acid B (SAB) from Chinese medicine on the shear-induced early and late stages of apoptosis in cultured rat cerebral mic...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Li M,Zhao MQ,Kumar Durairajan SS,Xie LX,Zhang HX,Kum WF,Goto S,Liao FL

    更新日期:2008-01-01 00:00:00

  • Haemorheological profile in congenital afibrinogenemia and in congenital dysfibrinogenemia: A clinical case report.

    abstract::Although the inherited quantitative and qualitative disorders of fibrinogen are rare, in the course of time patients may develop complications including episodes of arterial and venous thrombosis. It can be useful to complete the laboratory assessment of these clinical conditions with the evaluation of the haemorheolo...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-180542

    authors: Caimi G,Raso S,Napolitano M,Hopps E,Lo Presti R,Siragusa S

    更新日期:2019-01-01 00:00:00

  • Relationships among body composition, hemorheology and exercise performance in rugbymen.

    abstract::We investigated relationships among body composition, blood rheology, and exercise performance in 14 rugbymen (19-31 yr, weight 65.8-109.2 kg, height 1.7-1.96 m, body mass index 21.7-33.1 kg/m2) who underwent a standardized submaximal exercise session on cycloergometer corresponding to 225 kJ over 30 min. The rheologi...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Bouix D,Peyreigne C,Raynaud E,Monnier JF,Micallef JP,Brun JF

    更新日期:1998-11-01 00:00:00

  • Arterio-venous gradients of endothelial progenitor cells reveal a complex kinetics in human limb ischemia.

    abstract::Ischemic recruitment of endothelial progenitor cells (EPCs) in involved in compensatory angiogenic in animal models, but this still needs to be substantiated in humans. We enrolled 12 patients, who underwent surgical correction of abdominal aortic aneurysm without atherosclerosis of leg arteries (n = 4) or lower limb ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2011-1437

    authors: Fadini GP,Grego F,Menegolo M,Agostini C,Avogaro A

    更新日期:2012-01-01 00:00:00

  • Effects of haemoglobin levels on the sublingual microcirculation in pregnant women.

    abstract::Anemia in pregnant women is associated with increased maternal and perinatal mortality and represents an important economic burden in many developing countries. Our goal was to evaluate the impact of anemia on the capillary network during pregnancy. Therefore, we compared microcirculatory parameters of anemic pregnant...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-162064

    authors: Sharawy N,Hussein A,Hossny O,Refaa A,Saka A,Mukhtar A,Whynot S,George R,Lehmann C

    更新日期:2016-11-25 00:00:00

  • Elevated hematocrit in nonalcoholic fatty liver disease: a potential cause for the increased risk of cardiovascular disease?

    abstract:BACKGROUND AND AIM:Hematocrit is an important hemorheological parameter. Both hematocrit and nonalcoholic fatty liver disease (NAFLD) are strongly correlated with cardiovascular disease. However, there is no study to explore the direct relationship of hematocrit with NAFLD. METHODS:Hematocrit levels were analyzed from...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2011-1509

    authors: Li G,Hu H,Shi W,Li Y,Liu L,Chen Y,Hu X,Wang J,Gao J,Yin D

    更新日期:2012-01-01 00:00:00

  • Lipid peroxidation and total antioxidant status in juvenile myocardial infarction.

    abstract::In a group of young subjects with acute myocardial infarction (AMI) (97 men and 8 women; mean age 39.6+/-5.5 years) we examined the thiobarbituric acid - reactive substances and the total antioxidant status at the initial stage and after 12 months. The same parameters were examined in a group of 55 control subjects. O...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Lo Presti R,Carollo C,Montana M,Canino B,Catania A,Caimi G

    更新日期:2008-01-01 00:00:00

  • B-flow and B-flow with 3D and SRI postprocessing before intervention and monitoring after stenting of the internal carotid artery.

    abstract:OBJECTIVE:To investigate the extent to which B-flow and B-flow with 3D postprocessing and speckle reduction imaging (SRI) have advantages in appraising the morphology of a high-grade stenosis of the internal carotid artery (ICA) for preinterventional planning and for postinterventional ultrasonographic follow-up. MATE...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Jung EM,Kubale R,Clevert DA,Weskott HP,Prantl L,Herold T,Renz M,Rupp N,Tacke J

    更新日期:2007-01-01 00:00:00

  • Sequential analysis of erythrocyte aggregation in health and diseases.

    abstract::Aggregation of erythrocytes requires prolonged interaction of cellular and plasma constituents similar to in vivo conditions. To achieve this and then to analyse this process in various clinical and laboratory conditions, a PC-AT based system is developed. The erythrocyte suspension at 5% hematocrit in plasma is place...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Singh M,Kumaravel M

    更新日期:1997-07-01 00:00:00

  • Shear stress and force required for tether formation of neonatal and adult erythrocytes.

    abstract::Red blood cells (RBC) of neonates have a shorter survival time and they are more susceptible to mechanical alterations than RBC of adults. Irreversible alteration of the membrane of RBC of preterm neonates, term neonates and adults due to tether formation was studied by means of a micropipette technique. Shear stress ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2011-1390

    authors: Ruef P,Gehm J,Gehm L,Pöschl J

    更新日期:2011-01-01 00:00:00

  • Relationships between von Willebrand factor and hemorheology in sportsmen.

    abstract::It is well established that exercise performance in athletes is related to improved blood fluidity. However, training effects on functional state of endothelium and relations of endothelial cell functions with hemorheology are poorly known. Circulating levels of von Willebrand factor may serve as a good marker of endo...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Melnikov AA,Vikulov AD,Bagrakova SV

    更新日期:2003-01-01 00:00:00

  • Slow flow of passive neutrophils and sequestered nucleus into micropipette.

    abstract::In the present study, the role of the nucleus and its contribution to the deformability of the passive neutrophils was investigated. To determine the rheological properties of the nucleus and of the neutrophil itself, deformation tests on single neutrophil and sequestered nucleus have been performed by micropipette un...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2010-1326

    authors: Kaleridis V,Athanassiou G,Deligianni D,Missirlis Y

    更新日期:2010-01-01 00:00:00