Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway.

abstract：:Spectrofluorimetry experiments using synthetic trisaccharides indicate that in compounds that display affinity for antithrombin III (AT-III), a unique trisaccharide sequence plays the key role in the early recognition, and the first step of AT-III activation. Added to previous observations, these new results suggest t...

journal_title：Glycobiology

authors： Petitou M,Barzu T,Herault JP,Herbert JM

更新日期：1997-04-01 00:00:00

abstract：:Epithelial cells in the lining of the intestines play critical roles in maintaining homeostasis while challenged by dynamic and sudden changes in luminal contents. Given the high density of glycosylation that encompasses their extracellular surface, environmental changes may lead to extensive reorganization of membran...

journal_title：Glycobiology

authors： Park D,Xu G,Barboza M,Shah IM,Wong M,Raybould H,Mills DA,Lebrilla CB

更新日期：2017-09-01 00:00:00

abstract：:N-Glycanase 1, encoded by NGLY1, catalyzes the deglycosylation of misfolded N-linked glycoproteins retrotranslocated into the cytosol. We identified nine cases with mutations in NGLY1. The patients show developmental delay, seizures, peripheral neuropathy, abnormal liver function and alacrima (absence of tears). The m...

journal_title：Glycobiology

authors： He P,Grotzke JE,Ng BG,Gunel M,Jafar-Nejad H,Cresswell P,Enns GM,Freeze HH

更新日期：2015-08-01 00:00:00

abstract：:In this work, focused on possible application of α-L-fucosidases from bacterial sources in the synthesis of α-L-fucosylated glycoconjugates, several nonpathogenic aerobic bacterial strains were screened for α-L-fucosidase activity. Among them Paenibacillus thiaminolyticus was confirmed as a potent producer of enzyme w...

journal_title：Glycobiology

authors： Benesová E,Lipovová P,Dvoráková H,Králová B

更新日期：2013-09-01 00:00:00

abstract：:Glycolipids are important components of almost all biological membranes. They possess unique properties that have only been incompletely characterized so far. The plant glycolipid digalactosyldiacylglycerol (DGDG) strongly influences the physical behavior of phospholipid model membranes in both the dry and hydrated st...

journal_title：Glycobiology

authors： Popova AV,Hincha DK

更新日期：2005-11-01 00:00:00

abstract：:The gut microbiota plays a major role in human health and an alteration in gut microbiota structure and function has been implicated in several diseases. In the colon, mucus covering the epithelium is critical to maintain a homeostatic relationship with the gut microbiota by harbouring a microbial community at safe di...

journal_title：Glycobiology

authors： Bell A,Juge N

更新日期：2020-10-09 00:00:00

abstract：:The sialic acid-specific cytotoxic lectin viscumin and its recombinant equivalent rViscumin specifically bind to CD75s-gangliosides with terminal Neu5Acα6Galβ4GlcNAc sequence. We, therefore, comparatively analyzed the content of CD75s-gangliosides and closely related iso-CD75s-gangliosides (terminated by Neu5Acα3Galβ4...

journal_title：Glycobiology

authors： Souady J,Hülsewig M,Distler U,Haier J,Denz A,Pilarsky C,Senninger N,Dreisewerd K,Peter-Katalinic J,Müthing J

更新日期：2011-05-01 00:00:00

abstract：:Natural human interferon (IFN)-gamma has mainly biantennary complex-type sugar chains and scarcely has multiantennary structures. We attempted to remodel the sugar chain structures using IFN-gamma as a model glycoprotein. To obtain the branching glycoforms of IFN-gamma, we introduced the genes for GnT-IV (UDP-N-acetyl...

journal_title：Glycobiology

authors： Fukuta K,Abe R,Yokomatsu T,Kono N,Asanagi M,Omae F,Minowa MT,Takeuchi M,Makino T

更新日期：2000-04-01 00:00:00

abstract：:Beta-1,2-linked mannosides from Candida albicans phosphopeptidomannan (PPM) bind to macrophages through a receptor independent from the macrophage alpha-linked mannose receptor and stimulate these cells to secrete immune mediators. Anti-beta-1,2-linked mannoside but not anti-alpha-linked mannoside antibodies produced ...

journal_title：Glycobiology

authors： Jouault T,Fradin C,Dzierszinski F,Borg-Von-Zepelin M,Tomavo S,Corman R,Trinel PA,Kerckaert JP,Poulain D

更新日期：2001-08-01 00:00:00

abstract：:Neisseria meningitidis serogroups A, B, C, Y, W135 and X are responsible for most cases of meningococcal meningitis. Neisseria meningitidis serogroup X has recently emerged as a contributor to outbreaks of disease in Africa, but there is currently no vaccine against serogroup X. Understanding of the biosynthesis of th...

journal_title：Glycobiology

authors： Muindi KM,McCarthy PC,Wang T,Vionnet J,Battistel M,Jankowska E,Vann WF

更新日期：2014-02-01 00:00:00

abstract：:We have employed fast atom bombardment mass spectrometry (FAB-MS) to screen the N-linked oligosaccharides of Bowes melanoma tissue plasminogen activator (mt-PA), and recombinant t-PAs produced by Chinese hamster ovary cells (rt-PA) and by a gene-enriched melanoma cell line (rmt-PA). These studies have confirmed the pu...

journal_title：Glycobiology

authors： Chan AL,Morris HR,Panico M,Etienne AT,Rogers ME,Gaffney P,Creighton-Kempsford L,Dell A

更新日期：1991-03-01 00:00:00

abstract：:All IgG-type antibodies are N-glycosylated in their Fc part at Asn-297. Typically, a fucose residue is attached to the first N-acetylglucosamine of these complex-type N-glycans. Antibodies lacking core fucosylation show a significantly enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) and an increased effi...

journal_title：Glycobiology

authors： von Horsten HH,Ogorek C,Blanchard V,Demmler C,Giese C,Winkler K,Kaup M,Berger M,Jordan I,Sandig V

更新日期：2010-12-01 00:00:00

abstract：:The substrate specificity of the alpha-D-mannosidases of rat liver lysosome and cytosol was examined using oligosaccharides of the oligomannosidic type. The hydrolysis products were characterized by 400 MHz 1H-NMR spectroscopy. Both catabolic pathways occur in ordered ways, but are quite different. In fact, the lysoso...

journal_title：Glycobiology

authors： Haeuw JF,Michalski JC,Strecker G,Spik G,Montreuil J

更新日期：1991-11-01 00:00:00

abstract：:Recent studies have shown that O-mannosyl glycans are present in several mammalian glycoproteins. Although knowledge on the functional roles of these glycans is accumulating, their biosynthetic pathways are poorly understood. Here we report the identification and initial characterization of a novel enzyme capable of f...

journal_title：Glycobiology

authors： Takahashi S,Sasaki T,Manya H,Chiba Y,Yoshida A,Mizuno M,Ishida H,Ito F,Inazu T,Kotani N,Takasaki S,Takeuchi M,Endo T

更新日期：2001-01-01 00:00:00

abstract：:The synthesis of Galalpha1-3Gal-terminated oligosaccharides (alpha-Gal) epitopes has been interrupted during the course of evolution, starting with Old World primates. Partial sequences similar to the alpha1,3-galactosyltransferase (alpha1,3GalT) gene, which governs the synthesis of alpha-Gal epitopes, have been detec...

journal_title：Glycobiology

authors： Lantéri M,Giordanengo V,Vidal F,Gaudray P,Lefebvre JC

更新日期：2002-12-01 00:00:00

abstract：:The N-glycans of human serum transferrin produced in Trichopulsia ni cells were analyzed to examine N-linked oligosaccharide processing in insect cells. Metabolic radiolabeling of the intra- and extracellular protein fractions revealed the presence of multiple transferrin glycoforms with molecular weights lower than t...

journal_title：Glycobiology

authors： Ailor E,Takahashi N,Tsukamoto Y,Masuda K,Rahman BA,Jarvis DL,Lee YC,Betenbaugh MJ

更新日期：2000-08-01 00:00:00

abstract：:Macrophages are major cells of inflammatory process and take part in a large number of physiological and pathological processes. According to tissue environment, they can polarize into pro-inflammatory (M1) or alternative (M2) cells. Although many evidences have hinted to a potential role of cell-surface glycosaminogl...

journal_title：Glycobiology

authors： Martinez P,Denys A,Delos M,Sikora AS,Carpentier M,Julien S,Pestel J,Allain F

更新日期：2015-05-01 00:00:00

abstract：:In this work, we analyzed at high resolution the sugar-binding mode of the recombinant N-terminal ricin-B domain of the hemolytic protein LSLa (LSL(150)) from the mushroom Laetiporus sulphureus and also provide functional in vitro evidence suggesting that, together with its putative receptor-binding role, this module ...

journal_title：Glycobiology

authors： Angulo I,Acebrón I,de las Rivas B,Muñoz R,Rodríguez-Crespo I,Menéndez M,García P,Tateno H,Goldstein IJ,Pérez-Agote B,Mancheño JM

更新日期：2011-10-01 00:00:00

abstract：:The transcriptional regulation mechanisms involved in the up-regulation of Fas-induced GD3 synthase gene have not yet been elucidated. 5'-Rapid amplification of cDNA end (5'-RACE) using mRNA prepared from Fas-induced Jurkat T cells revealed the presence of multiple transcription start sites of human GD3 synthase gene,...

journal_title：Glycobiology

authors： Kang NY,Kang SK,Lee YC,Choi HJ,Lee YS,Cho SY,Kim YS,Ko JH,Kim CH

更新日期：2006-05-01 00:00:00

abstract：:Two kinds of molecules, one recognizing the sialo-/asialo-N-acetyllactosamine structures and the other recognizing the Lewis X structure in a divalent cation-independent manner, were detected on the head of boar sperm prepared from cauda epididymis by fluorescence-labeled or biotinylated dextran-based multivalent olig...

journal_title：Glycobiology

authors： Yoshitani N,Mori E,Takasaki S

更新日期：2001-04-01 00:00:00

abstract：:The structure of the complex mixture of the core oligosaccharide components of the lipooligosaccharide (LOS) fraction of Agrobacterium tumefaciens strain TT111 was determined directly on the deacetylated products by means of spectroscopical methods. The rhamnan oligosaccharide elongating the inner Kdo residue shares s...

journal_title：Glycobiology

authors： De Castro C,Carannante A,Lanzetta R,Liparoti V,Molinaro A,Parrilli M

更新日期：2006-12-01 00:00:00

abstract：:Lipid-A represents the ubiquitous, covalently bound hydrophobic component of bacterial lipopolysaccharides (endotoxins). Lipid-As isolated and characterized from rhizobial species have large variations in their backbone sugars, as well as in their hydroxy fatty acid substituents. The sugar backbones consist of either ...

journal_title：Glycobiology

authors： Bhat UR,Carlson RW

更新日期：1992-12-01 00:00:00

abstract：:Human milk oligosaccharides (HMOS) are not digested in the proximal intestine. In distal intestine, HMOS collectively modify the microbiota, but the response of individual bacteria to individual components of the HMOS is not well defined. Here, each of 25 major isolates of the human intestinal microbiota was fed indiv...

journal_title：Glycobiology

authors： Yu ZT,Chen C,Newburg DS

更新日期：2013-11-01 00:00:00

abstract：:In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules fro...

journal_title：Glycobiology

authors： Mast SW,Diekman K,Karaveg K,Davis A,Sifers RN,Moremen KW

更新日期：2005-04-01 00:00:00

abstract：:The evolutionarily conserved Notch signaling pathway plays broad and important roles during embryonic development and in adult tissue homeostasis. Unlike most other pathways used during animal development, Notch signaling does not rely on second messengers and intracellular signaling cascades. Instead, pathway activat...

journal_title：Glycobiology

authors： Jafar-Nejad H,Leonardi J,Fernandez-Valdivia R

更新日期：2010-08-01 00:00:00

abstract：:Trehalose synthase (TreS) catalyzes the reversible conversion of maltose into trehalose in mycobacteria as one of three biosynthetic pathways to this nonreducing disaccharide. Given the importance of trehalose to survival of mycobacteria, there has been considerable interest in understanding the enzymes involved in it...

journal_title：Glycobiology

authors： Caner S,Nguyen N,Aguda A,Zhang R,Pan YT,Withers SG,Brayer GD

更新日期：2013-09-01 00:00:00

abstract：:The occurrence of a terminal disialyl motif on mammalian O-glycans is increasingly being identified through recent mass spectrometry (MS)-based glycomic profiling. In most cases, it is carried on simple core 1 structures in which both the galactose and N-acetyl galactosamine can be disialylated. In contrast, a disialy...

journal_title：Glycobiology

authors： Wang SH,Tsai CM,Lin KI,Khoo KH

更新日期：2013-06-01 00:00:00

abstract：:β-Trefoil lectins are galactose/N-acetyl galactosamine specific lectins, which are widely distributed across all kingdoms of life and are known to perform several important functions. However, there is no report available on the characterization of these lectins from protozoans. We have performed structural and biophy...

journal_title：Glycobiology

authors： Khan F,Kurre D,Suguna K

更新日期：2020-07-20 00:00:00

abstract：:Heparan sulfate/heparin N-deacetylase/N-sulfotransferase-1 (NDST-1) is a critical enzyme involved in heparan sulfate/heparin biosynthesis. This dual-function enzyme modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan. N-sulfation is an absolute requirement for the subsequent epi...

journal_title：Glycobiology

authors： Saribaş AS,Mobasseri A,Pristatsky P,Chen X,Barthelson R,Hakes D,Wang J

更新日期：2004-12-01 00:00:00

abstract：:Oral treatment of mice, cutaneously infected with herpes simplex virus type 1 (HSV-1) (strain SC16), with the alpha-glucosidase 1 inhibitor 6-O-butanoyl castanospermine (MDL 28,574) produced a significant delay in lesion development and reduced the amount of virus recovered from the brain. Virus load in the brains of ...

journal_title：Glycobiology

authors： Bridges CG,Ahmed SP,Kang MS,Nash RJ,Porter EA,Tyms AS

更新日期：1995-03-01 00:00:00