Abstract:
:Oral treatment of mice, cutaneously infected with herpes simplex virus type 1 (HSV-1) (strain SC16), with the alpha-glucosidase 1 inhibitor 6-O-butanoyl castanospermine (MDL 28,574) produced a significant delay in lesion development and reduced the amount of virus recovered from the brain. Virus load in the brains of mice, whose treatment started 2 days prior to infection, was reduced approximately 100-fold when compared to untreated controls. Treatment initiated at the time of infection, while less effective than pre-treatment, nevertheless reduced virus recovery from the brain by 10-fold. Consistent with its antiviral activity, orally administered MDL 28,574 was rapidly incorporated by brain tissue and mice fed with compound over extended periods maintained relatively high levels of drug at this site.
journal_name
Glycobiologyjournal_title
Glycobiologyauthors
Bridges CG,Ahmed SP,Kang MS,Nash RJ,Porter EA,Tyms ASdoi
10.1093/glycob/5.2.249subject
Has Abstractpub_date
1995-03-01 00:00:00pages
249-53issue
2eissn
0959-6658issn
1460-2423journal_volume
5pub_type
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