Abstract:
:Since their recent identification, eukaryotic Hsp70 nucleotide exchange factors (NEFs) have gained increasing interest due to their engagement in vital cellular processes. Here, I summarize our current knowledge of their mechanisms of action, regulations and cellular functions as well as their relevance for human diseases such as cystic fibrosis or amyloidoses.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Kabani Mdoi
10.2174/092986609788490186subject
Has Abstractpub_date
2009-01-01 00:00:00pages
623-60issue
6eissn
0929-8665issn
1875-5305journal_volume
16pub_type
杂志文章,评审abstract:BACKGROUND:Type VI Secretion System (T6SS) has been found in approximately onequarter of the gram-negative bacterial species, and its structural characteristics appear to slightly differ from species to species. The genes encoding T6SS are designated as type six secretion A-M (tssA-M). The expression of the tss gene cl...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190119121859
更新日期:2019-01-01 00:00:00
abstract::F(0)F(1)-ATPase is a rotary molecular motor. It is well known that the rotary torque is generated by ATP hydrolysis in F(1) but little is known about how it produces the proton-motive force (PMF) in F(0). Here a cross-linking approach was used to estimate the rotary torque produced by PMF. Three mutant E. coli strains...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986607779117164
更新日期:2007-01-01 00:00:00
abstract::The cyclotides are a large family of plant proteins that have a cyclic backbone and a knotted arrangement of three conserved disulfide bonds. Despite the apparent complexity of their cystine knot motif it is possible to efficiently fold these proteins, as exemplified by oxidative folding studies on the prototypic cycl...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866053005863
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:A core sequence (the 9 C-terminal residues) of calcification-associated peptide (CAP- 1) isolated from the exoskeleton of the red swamp crayfish was previously shown to control calcium carbonate precipitation with chitin. In addition, a modified core sequence in which the phosphorylated serine at the N termi...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666171221114658
更新日期:2018-01-01 00:00:00
abstract::The small heat shock protein SsHSP14.1 from the hyper-thermophilic archeaon, Sulfolobus solfataricus (S. solfataricus) was able to protect proteins from thermal aggregation and prevent enzymes from heat induced inactivation. According to the 3D (dimensional) structural model of SsHSP14.1 developed by us before, the re...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611794578369
更新日期:2011-03-01 00:00:00
abstract::With a huge amount of protein sequence data, the computational method for protein-protein interaction (PPI) prediction using only the protein sequences information have drawn increasing interest. In this article, we propose a sequence-based method based on a novel representation of local protein sequence descriptors. ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610791760306
更新日期:2010-09-01 00:00:00
abstract::During spermiogenesis, the elongating rat spermatid chromatin undergoes a gradual process of condensation which is initiated in the round spermatids at "step 7" of cytodifferentation in stage VII and extending to elongated spermatids at "step 19" of cytodifferentiation in stage VIII. The mechanism of chromatin condens...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986611795714005
更新日期:2011-08-01 00:00:00
abstract::Annual ryegrass (Lolium multiflorum) is widely used as a cool-season forage grass for its luxuriant growth, palatable and high digestible. To investigate the salt tolerance mechanism in annual ryegrass under salt stress, salt-tolerant genotype 'R102-3' and salt-sensitive genotype 'Tetragold' were subject to 300mmol/L ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866523666160314153618
更新日期:2016-01-01 00:00:00
abstract::Sry-related box (Sox) transcription factors share a conserved high-mobility-group box domain (HMG-domain) that binds DNA in the minor groove and bends DNA for further assembly of transcriptional machineries. During organogenesis, each member of the Sox family triggers a specific cell lineage differentiation, indicatin...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:
更新日期:2013-04-01 00:00:00
abstract::Galanin is a neuropeptide that is widely distributed in the central and peripheral nervous systems. Some small cell lung carcinoma (SCLC) cell lines such as SBC-3A release only the high-molecular-mass form, with lower molecular mass forms being undetectable. To investigate the mechanism of processing of progalanin to ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611796378693
更新日期:2011-10-01 00:00:00
abstract::We here describe a new strategy for the delivery of oligonucleotides to cells that is based on the use of a short peptide containing three functional units: a membrane-penetrating segment, a DNA-binding domain and a cell-localization sequence. The designed vector binds strongly to oligonucleotides and has membrane-per...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866033408291
更新日期:2003-02-01 00:00:00
abstract::Familial mediterranean fever (FMF) is a systemic disorder characterized by recurrent attacks of fever and polyserositis. In FMF, several pro-inflammatory cytokines have been found to be elevated during the attacks. In recent years, it is shown that some proteins originated from adipose tissue play important role in in...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610792231555
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Laminin, a member of the Extracellular Matrix (ECM), is a glycoprotein that is used as a factor that affects cell adhesion, proliferation, survival, and differentiation. Of these, five globular domains (LG domains) of the alpha chain play an important role in influencing the cell by binding to the integrin. ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190617091155
更新日期:2019-01-01 00:00:00
abstract::Protein structure information is very useful for the confirmation of protein function. The protein structural class can provide information for protein 3D structure analysis, causing the conformation of the protein overall folding type plays a significant part in molecular biology. In this paper, we focus on the predi...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612803217051
更新日期:2012-11-01 00:00:00
abstract::For biophysical studies using heteronuclear NMR analysis of amyloid beta peptide, construction of an efficient and high yield expression system of uniformly isotopic labeled amyloid beta peptide is desirable. Here we succeeded in obtaining (15)N-labeled amyloid beta 1-40 expressed by attachment to hen egg white lysozy...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986607781483741
更新日期:2007-01-01 00:00:00
abstract::Nudix hydrolases catalyze the hydrolysis of nucleoside diphosphates linked to other moieties X, and contain the sequence motif or Nudix box, GX5EX7REUXEEXGU. The mechanisms of Nudix hydrolases are highly diverse in the position on the substrate. In this paper, we examined the sequences and structures of the MutT/Nudix...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608783330350
更新日期:2008-01-01 00:00:00
abstract::The reaction between Arg-Gly-Asp (RGD) and Lys-Gly-Asp (KGD) derivatives with 3,4',5-trihydroxy-trans-stilbene (resveratrol) was investigated. Knowing that resveratrol, RGD as well as KGD analogues inhibit human platelet aggregation in vitro, it was tempting for us to examine whether their coupling products present en...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986607782541141
更新日期:2007-01-01 00:00:00
abstract::After several studies on prediction of mutation, we examine the effect of three sampling strategies, the sampling based on years, the sampling based on number of mutations, and the sampling based on the unpredictable portion of amino-acid pairs, on the prediction performance in H5N1 hemagglutinins. The results show th...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608785133735
更新日期:2008-01-01 00:00:00
abstract::α-Synuclein forms amyloid deposits in the dopaminergic neurons; a process that is believed to contribute to the Parkinson's disease. An emerging theme in amyloid research is the hypothesis that the toxic species produced during amyloid formation share common physic-chemical features and exert their effects by common m...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866522666150209142649
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Fruit juice clarification is a challenging aspect of beverage industry which needs to be addressed for economical and hygienic production of fruit juices. OBJECTIVE:Current study is focused on the complete purification, characterization and thermodynamic analysis of an efficient mannanase enzyme to analyze ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200916142305
更新日期:2020-09-16 00:00:00
abstract::Colon cancer is one of the most common malignances. In vitro and in vivo study show that retinoic acids inhibit a wide variety of cancer cells but the molecular mechanism of their anti-tumor effects are not yet fully understood. Alltrans retinoic acid (ATRA), an isomer of retinoic acid, can inhibit the proliferation o...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612803521675
更新日期:2012-12-01 00:00:00
abstract::Natural, synthetic and analogues of peptides have shown prospects for application in cancer chemotherapy. Notably, some food protein-derived peptides are known to possess anticancer activities in cultured cancer cells, and also in animal cancer models via different mechanisms including induction of apoptosis, cell cyc...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866523666160816152755
更新日期:2017-01-01 00:00:00
abstract::Human ankyrin repeat and suppressor of cytokine signaling box protein 9 (hASB9), a subunit of an Elongin C-cullin-SOCS box (ECS) E3 ubiquitin ligase complex, is believed to be involved in specific substrate-recognition for ubiquitination and degradation. In fact, this specific substrate-recognition is determined by th...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609787601688
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:OPT3s are involved in the transport of Fe from xylem to phloem, in loading Fe into phloem, and in the transmission of shoot-to-root iron signaling. Yet, apart from Arabidopsis, little is known about these transporters'functions in other plant species. OBJECTIVE:OPT3 proteins of several plant species were ch...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200625202028
更新日期:2020-06-25 00:00:00
abstract::Proteases have been used not only for proteolysis but also in organic solvent-assisted religation processes. Here, we demonstrated the effect of salts on peptide bond resynthesis in Glutathione-S-transferase (GST) and have found it to be in the purview of the Hofmeister phenomena. Our results show that the efficiency ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610789909395
更新日期:2010-01-01 00:00:00
abstract::AB204 is an Activin/BMP2 chimera, which has been found to exhibit a higher activity than Bone Morphogenetic Protein 2 (BMP2) in osteogenic activity. To prepare AB204 for its preclinical studies, AB204 has been characterized in various formulation buffers. We observed that AB204 purified by ion-exchange chromatography ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986652105140218110302
更新日期:2014-05-01 00:00:00
abstract::Zwitterionic dipeptides have recently been shown to exist in water mainly as nine conformational forms with specific combinations of backbone Psi, omega and Phi torsions, which allows conformer-specific molecular recognition of peptide ligands by proteins. Here, we show that pairs of virtual backbone torsions can also...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866023408904
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:The heterologous production of antimicrobial peptides in bacterial models can produce insoluble proteins due to the lack of proper folding. Fusion proteins have been used to increase the expression and solubility of these types of proteins with varying degrees of success. OBJECTIVES:Here, we demonstrate the...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200610133407
更新日期:2020-06-10 00:00:00
abstract::The formation of local structure, in short peptides has been probed by examining cleavage patterns and rates of proteolysis of designed sequences with a high tendency to form beta-hairpin structures. Three model sequences which bear fluorescence donor and acceptor groups have been investigated: [see text]. Fluorescenc...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606776819501
更新日期:2006-01-01 00:00:00
abstract::Adenoregulin is a 33 amino acid antibiotic peptide who belongs to dermaseptin family which is the first vertebrate family to show lethal effects against filamentous fungi, as well as a broad spectrum of pathogenic microorganisms. Synthetic adenoregulin gene was cloned in 2, 4 and 6 tandem repeats and subcloned in pET3...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866053765671
更新日期:2005-05-01 00:00:00