Abstract:
:The aim of this study was to investigate the potential effects of vitamin K1 supplementation on skeletal changes related to fluoride in growing rats. Forty male Wistar rats aged 4 weeks were assigned at random into three groups: high-dose fluoride (125 ppm) group; high-dose fluoride + vitamin K1 (0.2 mg/(g day)) group; and a control group. The experimental period was 12 weeks. The L3 vertebrae and the right tibiae were removed, and specimens were analysed by histologic and histomorphometric methods. Quantitative radiodensitometry was also employed to assess the differences in bone mineral density (BMD) between the groups. In the tibia, total tissue area was higher in the study groups than the control group (P < 0.05). Cortical bone area was slightly higher in the fluoride + K1 group than the fluoride group, and marrow cavity area was lower in the fluoride + K1 group (P < 0.05). In the L3 vertebral cancellous bone, bone volume, trabecular number and trabecular thickness were higher in the study groups than the control group (P < 0.05). Trabecular separation was reduced in the study groups (P < 0.05), and was lower in the fluoride + K1 group than the fluoride group (P < 0.05). The fluoride + K1 group had a significantly higher BMD than the other groups (P < 0.05), and the fluoride group had a significantly higher BMD than the control group (P < 0.05). The present study found that fluoride administration increased bone mass in both vertebrae and tibiae in growing rats. Simultaneous administration of vitamin K1 and fluoride resulted in an additional increase in vertebral bone mass.
journal_name
Arch Oral Bioljournal_title
Archives of oral biologyauthors
Cadir B,Kürkcü M,Oz ĺA,Benlidayi MEdoi
10.1016/j.archoralbio.2009.02.001subject
Has Abstractpub_date
2009-06-01 00:00:00pages
512-7issue
6eissn
0003-9969issn
1879-1506journal_volume
54pub_type
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abstract::Previous studies of the sympathetic nerve supply of the rat mandibular incisor pulp have shown conflicting results. Here, the neurovascular control of the rat lower incisor pulp was investigated by stimulating the tooth crown and the cervical sympathetic trunk electrically and monitoring blood-flow changes in the pulp...
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abstract:OBJECTIVES:The antibacterial activity of Coffea canephora extract was evaluated in vitro against Streptococcus mutans and Streptococcus sobrinus. The viability of planktonic cells was analysed by susceptibility tests (MIC and MBC) and time-kill assays. The effect of the extract on dental demineralisation was also inves...
journal_title:Archives of oral biology
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doi:10.1016/j.archoralbio.2010.12.001
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abstract::Stimulation of muscarinic cholinergic receptors on rat parotid acinar cells causes a rapid production of inositol phosphates, with the key metabolic event being the breakdown of phosphatidylinositol 4,5-bisphosphate into inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and diacylglycerol. Here a high-performance liquid chr...
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journal_title:Archives of oral biology
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doi:10.1016/0003-9969(92)90087-o
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journal_title:Archives of oral biology
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journal_title:Archives of oral biology
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abstract::Mechanisms of primary fluid formation by macropodine mandibular glands were investigated in anaesthetized red kangaroos using ion-transport and carbonic anhydrase inhibitors. Bumetanide at carotid plasma concentrations of 0.005-0.1 mmol/l progressively reduced a stable, acetylcholine-evoked flow rate of 1.02 +/- 0.024...
journal_title:Archives of oral biology
pub_type: 杂志文章
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abstract::To investigate whether mechanical deformation of osteoblasts exerts an influence upon parathyroid hormone (PTH)-induced bone resorption, the effect of medium conditioned by a statistically stretched, osteoblast-enriched, bone cell population on PTH-induced osteoclast-like cell formation in mouse bone marrow cultures w...
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abstract::Boron Neutron Capture Therapy (BNCT) is a bimodal cancer treatment based on the selective accumulation of 10B in tumors and concurrent irradiation with thermalized neutrons. The short-range, high-LET radiation produced by the capture of neutrons by 10B could potentially control tumor while sparing normal tissue if the...
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journal_title:Archives of oral biology
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journal_title:Archives of oral biology
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
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