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The varieties of gene amplification, diversification and hypervariability in the human malaria parasite, Plasmodium falciparum.

Abstract：

:The human malaria parasite, Plasmodium falciparum, is able to evade host cell-mediated and humoral immunity to maintain both persistent and repeated infections. Immune evasion is in part due to a robust repertoire of proteins which participate in host-parasite interactions but also exhibit profound antigenic diversity, and in some instances switches in gene expression. The antigenic diversity occurs both at the parasite level within families of amplified proteins, and within populations of parasites in which mechanisms of recombination and gene conversion conspire to create a broad plasticity in the antigenic exposure to the host. This review will introduce the spectrum of amplified protein families in P. falciparum and focus on three sub-telomeric encoded families, RIFIN, STEVOR and Pfmc-2TM which exhibit hypervariability with respect to their antigenic diversity.

journal_name

Mol Biochem Parasitol

journal_title

Molecular and biochemical parasitology

authors

Templeton TJ

doi

10.1016/j.molbiopara.2009.04.003

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

109-16

issue

2

eissn

0166-6851

issn

1872-9428

pii

S0166-6851(09)00117-0

journal_volume

166

pub_type

杂志文章,评审

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