Abstract：
:Recent transcript profiling and microarray studies are beginning to unveil some of the mysteries of sleep. One of the most important clues has been the identification of the endoplasmic reticulum (ER) resident chaperone, immunoglobulin binding protein (BiP), that increases with sleep deprivation in all species studied. BiP, an ER resident chaperone, is the key cellular marker and master regulator of a signaling pathway called the ER stress response or unfolded protein response. The ER stress response occurs in 3 phases. It is healthy, protective and adaptive when the ER stress is moderate. Failure of the adaptive response leads to the activation of an inflammatory response. When the ER stress burden is great and prolonged, executioner pathways are activated. Collectively this work provides new evidence that modest sleep deprivation induces cellular stress that activates an adaptive response. Aging tilts the response to sleep deprivation from one that is adaptive and protective to one that is maladaptive. Understanding the pathways activated by sleep loss and the mechanisms by which they occur will allow the development of therapies to protect the brain during prolonged wakefulness and specifically in sleep disorders including those associated with aging.
journal_name
Sleep Med Revjournal_title
Sleep medicine reviewsauthors
Naidoo Ndoi
10.1016/j.smrv.2009.01.001subject
Has Abstractpub_date
2009-06-01 00:00:00pages
195-204issue
3eissn
1087-0792issn
1532-2955pii
S1087-0792(09)00005-7journal_volume
13pub_type
杂志文章,评审abstract：:Large elastic arteries and smaller muscular conduit arteries become stiffer with ageing, a process that is accelerated in the presence of cardiovascular disease (CVD). In recent years, numerous techniques have been developed to measure arterial stiffness, either in single vessels or in entire muscular arterial trees. ...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2012.03.002
更新日期：2013-02-01 00:00:00
abstract：:Psychiatric chronotherapeutics is the controlled exposure to environmental stimuli that act on biological rhythms in order to achieve therapeutic effects in the treatment of psychiatric conditions. In recent years some techniques (mainly light therapy and sleep deprivation) have passed the experimental developmental p...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2007.06.004
更新日期：2007-12-01 00:00:00
abstract：:Vitamin D insufficiency is common in the healthy population. Recent insights addressed the role of vitamin D in serotonin and melatonin regulation, suggesting that increasing vitamin D status may be helpful for improving mood and sleep. This literature review covers the current state of evidence regarding potential ef...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2020.101379
更新日期：2021-02-01 00:00:00
abstract：:Questionnaires are a useful and extensively used tool in clinical sleep medicine and in sleep research. The number of sleep questionnaires targeting the pediatric age range has tremendously increased in recent years, and with such explosion in the number of instruments, their heterogeneity has become all the more appa...
journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1016/j.smrv.2010.06.003
更新日期：2011-02-01 00:00:00
abstract：:The cardiovascular co-morbidities of obstructive sleep apnea (OSA) are similar to those of obesity. Cardiovascular co-morbidities often are the cause of adverse outcomes in overweight/obese OSA patients. Continuous positive airway pressure (CPAP) therapy resolves the symptoms of OSA, but may, or may not lead to improv...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2016.12.001
更新日期：2018-02-01 00:00:00
abstract：:Aim of the present systematic review was to evaluate whether children and adolescents with attention-deficit/hyperactivity disorder (ADHD) are at greater chance of developing bruxism compared to individuals without this disorder. Observational studies that evaluated the occurrence of bruxism in children and adolescent...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2020.101330
更新日期：2020-10-01 00:00:00
abstract：:People with autism spectrum disorder (ASD) commonly experience other comorbidities. Studies indicate that between 50% and 83% of individuals with ASD have sleep problems or disorders. The most commonly reported sleep problems are: (a) insomnia symptoms including the inability to get to sleep or stay asleep; and (b) ci...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2020.101357
更新日期：2020-12-01 00:00:00
abstract：:Obesity is prevalent among pregnant women in the United States; 15-20% of obese pregnant women have obstructive sleep apnea. The prevalence of obstructive sleep apnea increases along with body mass index, age and in the presence of other co-morbidities. Untreated obstructive sleep apnea in women is associated with a r...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2018.05.004
更新日期：2018-12-01 00:00:00
abstract：:Cancer in children has detrimental effects on sleep patterns and sleep quality, which in turn impacts on the perception of, and the ability to cope with, the emotional and physical challenges associated with both the disease and its treatment. This places an added burden on their quality of life that can last many yea...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2015.01.001
更新日期：2015-12-01 00:00:00
abstract：:Patients with obstructive sleep apnoea (OSA) experience neuropsychological deficits falling broadly into the four areas of daytime sleepiness, cognitive deficits, reduced driving competence and impaired psychosocial well-being. Case-control studies of daytime function in OSA patients generally indicate moderate to sev...
journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1016/s1087-0792(99)90014-x
更新日期：1999-03-01 00:00:00
abstract：:Results from the present review challenge the assumption that daytime functioning deficits are associated with insomnia. Objectively-measured daytime sleepiness is not elevated in people with insomnia, and most cognitive/psychomotor tasks do not indicate deficits in people with insomnia. In contrast, a number of studi...
journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1053/smrv.1999.0074
更新日期：2000-06-01 00:00:00
abstract：:Despite advances in positive pressure therapy for obstructive sleep apnea, compliance continues to be a problem for many patients. Sleep apnea surgery is a viable option for patients who are intolerant of positive pressure therapy. This review will present the current state of art in sleep apnea surgery, including air...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2005.01.004
更新日期：2005-06-01 00:00:00
abstract：:Sleep disordered breathing (SDB) is a common disorder in both adults and children and is caused by the obstruction of the upper airway during sleep. Unlike adults, most cases of paediatric SDB are due to the presence of enlarged tonsils and adenoids, thus the main treatment option is adenotonsillectomy (T&A). It is we...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2012.04.004
更新日期：2013-02-01 00:00:00
abstract：:Disrupted nighttime sleep is one of the pentad of symptoms defining Narcolepsy. REM sleep behavior disorder (RBD) largely contributes to night sleep disruption and narcolepsy is the most common cause of secondary RBD. However, RBD linked to narcolepsy (N-RBD) has been insufficiently characterized, leaving unsolved a n...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2019.101254
更新日期：2020-04-01 00:00:00
abstract：:Disruption of the sleep-wake cycle is a risk factor and a prodromal indicator of delirium. Melatonergic agents may thus play a role in the prevention of delirium. Based upon literature search on eight databases, this systemic review and frequentist model network meta-analysis (NMA) aimed to determine the efficacy and ...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2019.101235
更新日期：2020-04-01 00:00:00
abstract：:Sleepiness and sleep propensity are strongly influenced by our circadian clock as indicated by many circadian rhythms, most commonly by that of core body temperature. Sleep is most conducive in the temperature minimum phase, but is inhibited in a "wake maintenance zone" before the minimum phase, and is disrupted in a ...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2008.02.003
更新日期：2008-08-01 00:00:00
abstract：:Understanding the long-term neuropsychological consequences of sleep disorders in children poses a significant challenge to researchers. Since children are in a state of rapidly changing cognition and neurobehavioral function, impacts on development may have profound consequences. Recent studies now demonstrate that m...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2005.10.002
更新日期：2006-04-01 00:00:00
abstract：:Among the range of primary insomnia subtypes, those assigned such labels as subjective insomnia or sleep state misperception historically have been among the most intriguing yet challenging to understand and manage clinically. Such patients who produce seemingly normal polysomnograms often present rather compelling an...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/smrv.2002.0253
更新日期：2003-06-01 00:00:00
abstract：:Sleepiness and fatigue are two interrelated, but distinct phenomena; observed in a number of psychiatric, medical and primary sleep disorders. Despite their different implications in terms of diagnosis and treatment, these two terms are often used interchangeably, or merged under the more general lay term of 'tired'. ...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2005.05.004
更新日期：2006-02-01 00:00:00
abstract：:Numerous studies have explored the effect of sleep on memory. It is well known that a period of sleep, compared to a similar period of wakefulness, protects memories from interference, improves performance, and might also reorganize memory traces in a way that encourages creativity and rule extraction. It is assumed t...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2017.09.001
更新日期：2018-06-01 00:00:00
abstract：:Traumatic events have been increasingly recognized as important precipitants of clinically significant insomnia. Trauma is an extreme form of stressful life event that generates a sustained neurobiological response triggering the onset and maintenance of insomnia. Trauma may disrupt the normal sleep-wake regulatory me...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2015.01.008
更新日期：2016-02-01 00:00:00
abstract：:This review is aimed at summarizing the current state of knowledge regarding parasomnias, which have been implicated in medicolegal cases as well as providing guidance to those working within common-law jurisdictions regarding the technical aspects of the law. Sleepwalking and sexsomnia as a defence are being raised m...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2013.07.004
更新日期：2014-06-01 00:00:00
abstract：:Jetlag is a combination of travel fatigue and circadian misalignment resulting from air travel across time zones. Routinely recommended interventions based on circadian science include timely exposure to light and darkness (scheduled sleep), but the real-world effectiveness of these and other non-circadian strategies ...
journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1016/j.smrv.2018.09.005
更新日期：2019-02-01 00:00:00
abstract：:Advances in neonatal care have improved the survival rates of preterm infants, however, the likelihood of brain injury and neurodevelopmental disability remains a significant problem. Whilst the etiology of preterm brain injury is complex, impairments in the cardio- and cerebro-vascular function have been implicated. ...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2017.10.001
更新日期：2018-06-01 00:00:00
abstract：:Opioid use whether acute or chronic, illicit or therapeutic is prevalent in Western societies. Opioid receptors are located in the same nuclei that are active in sleep regulation and opioid peptides are suggested to be involved in the induction and maintenance of the sleep state. mu-Opioids are the most commonly used ...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2006.03.006
更新日期：2007-02-01 00:00:00
abstract：:Magnesium supplementation is often suggested for restless legs syndrome (RLS) or period limb movement disorder (PLMD) based on anecdotal evidence that it relieves symptoms and because it is also commonly recommended for leg cramps. We aimed to review all articles reporting the effects of magnesium supplementation on c...
journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1016/j.smrv.2019.101218
更新日期：2019-12-01 00:00:00
abstract：:Exercise has promising effects on sleep disturbances and quality of life among cancer patients. Aerobic exercises (AE) and mind-body exercises (MBE) have different mechanisms for improving sleep, but whether they are effective remains unclear. This systematic review and meta-analysis is the first to examine the effect...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2020.101334
更新日期：2020-10-01 00:00:00
abstract：:Melatonin is synthesized and secreted during the dark period of the light-dark cycle. Thus, melatonin has an obvious association with sleep, at least in diurnal animals. Rhythmic nocturnal melatonin secretion is directly generated by the circadian clock, located in mammals within the suprachiasmatic nuclei (SCN), and ...
journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1016/s1087-0792(98)90020-x
更新日期：1998-08-01 00:00:00
abstract：:Rhythmic movement disorder consists of repetitive stereotypic movements, such as head banging or body rocking, that recur every second or so and may last from a few minutes to hours, usually prior to sleep onset. This review of childhood rhythmic movement disorder highlights the lack of systematic research into core a...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2016.08.003
更新日期：2017-10-01 00:00:00
abstract：:Based on electrophysiological, neurochemical, genetic and neuropharmacological approaches it is currently accepted that serotonin (5-HT) functions to promote waking (W) and to inhibit rapid-eye movement sleep (REMS). The serotonin-containing neurons of the dorsal raphe nucleus (DRN) provide part of the serotonergic in...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2009.10.003
更新日期：2010-10-01 00:00:00
