Abstract：
:Patients with obstructive sleep apnoea (OSA) experience neuropsychological deficits falling broadly into the four areas of daytime sleepiness, cognitive deficits, reduced driving competence and impaired psychosocial well-being. Case-control studies of daytime function in OSA patients generally indicate moderate to severe daytime sleepiness using polysomnographic or self-rating assessments. Cognitive performance on tests of attention and concentration ability, visuomotor and constructional skills, verbal fluency, planning and problem-solving, memory and executive function may be mildly to moderately impaired. These two symptoms may contribute to a road traffic accident rate in OSA between two and seven times higher than that of normals, and to the high prevalence of minor psychiatric morbidity, and reductions in functional and health status, among patients. The daytime impairments associated with OSA are improved by continuous positive airway pressure (CPAP) therapy, although a lack of complete normalization has been suggested for objective sleepiness and some areas of cognitive function. The severity of sleepiness and cognitive impairments show weak and moderate correlations with frequency of sleep-disordered breathing in clinical and epidemiological studies. Experimental and clinical evidence supports a role for nocturnal physiological events of OSA, arousals and hypoxaemia, in directly or indirectly producing neuropsychological deficits, particularly those of sleepiness and cognitive deterioration.
journal_name
Sleep Med Revjournal_title
Sleep medicine reviewsauthors
Engleman H,Joffe Ddoi
10.1016/s1087-0792(99)90014-xsubject
Has Abstractpub_date
1999-03-01 00:00:00pages
59-78issue
1eissn
1087-0792issn
1532-2955pii
S108707929990014Xjournal_volume
3pub_type
杂志文章abstract：:Cognitive behavioral therapy for insomnia (CBT-I) is effective for treatment of primary insomnia. There has been no synthesis of studies quantifying this effect on insomnia comorbid with medical and psychiatric disorders using rigorous selection criteria. The objective of this study was to quantify the effect of CBT-I...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.smrv.2014.11.007
更新日期：2015-10-01 00:00:00
abstract：:Understanding the long-term neuropsychological consequences of sleep disorders in children poses a significant challenge to researchers. Since children are in a state of rapidly changing cognition and neurobehavioral function, impacts on development may have profound consequences. Recent studies now demonstrate that m...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2005.10.002
更新日期：2006-04-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2017.04.002
更新日期：2018-04-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2019.101222
更新日期：2020-02-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2016.07.002
更新日期：2017-08-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2006.08.001
更新日期：2007-04-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2005.01.004
更新日期：2005-06-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2020.101360
更新日期：2020-12-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2018.05.004
更新日期：2018-12-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1016/s1087-0792(98)90051-x
更新日期：1998-02-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2020.101379
更新日期：2021-02-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1016/j.smrv.2018.09.005
更新日期：2019-02-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2019.05.005
更新日期：2019-10-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,meta分析
doi：10.1016/j.smrv.2018.10.006
更新日期：2019-02-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2009.01.001
更新日期：2009-06-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2017.09.001
更新日期：2018-06-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2020.101380
更新日期：2021-02-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2018.02.004
更新日期：2018-10-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2007.06.004
更新日期：2007-12-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2016.03.005
更新日期：2017-04-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1016/j.smrv.2019.101218
更新日期：2019-12-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2014.07.004
更新日期：2015-06-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2009.10.003
更新日期：2010-10-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1016/s1087-0792(97)90002-2
更新日期：1997-11-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2005.05.004
更新日期：2006-02-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,meta分析
doi：10.1016/j.smrv.2019.08.004
更新日期：2019-12-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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更新日期：2020-10-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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更新日期：2006-10-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2015.01.001
更新日期：2015-12-01 00:00:00
abstract：:Obstructive sleep apnea is an underdiagnosed sleep-related breathing disorder affecting millions of people. Recurrent episodes of apnea/hypopnea result in intermittent hypoxia leading to oxidative stress. Obstructive sleep apnea is considered an independent risk factor for cardiovascular disease but the exact pathophy...
journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1016/j.smrv.2019.03.010
更新日期：2019-08-01 00:00:00
