Abstract：
:Based on electrophysiological, neurochemical, genetic and neuropharmacological approaches it is currently accepted that serotonin (5-HT) functions to promote waking (W) and to inhibit rapid-eye movement sleep (REMS). The serotonin-containing neurons of the dorsal raphe nucleus (DRN) provide part of the serotonergic innervation of the telencephalon, diencephalon, mesencephalon and rhombencephalon of laboratory animals and man. The DRN has been subdivided into several clusters on the basis of differences in cellular morphology, expression of other neurotransmitters and afferent and efferent connections. These differences among subpopulations of 5-HT neurons may have important implications for neural mechanisms underlying 5-HT modulation of sleep and waking. The DRN contains 5-HT and non-5-HT neurons. The latter express a variety of substances including dopamine, γ-aminobutyric acid (GABA) and glutamate. In addition, nitric oxide and a number of neuropeptides have been characterized in the DRN. Available evidence tends to indicate that non-5-HT cells contribute to the regulation of the activity of 5-HT neurons during the sleep-wake cycle through local circuits and/or their mediation of the effects of afferent inputs. Mutant mice that do not express 5-HT(1A) or 5-HT(1B) receptor exhibit greater amounts of REMS than their wild-type couterparts. 5-HT(2A) and 5-HT(2C) receptor knockout mice show a significant increase of W and a reduction of slow wave sleep that is related, at least in part, to the increased release of norepinephrine and dopamine. A normal circadian sleep pattern is observed in 5-HT(7) receptor knockout mice; however, the mutants spend less time in REMS. Local microinjection of 5-HT(1B), 5-HT(2A/2C), 5-HT(3) and 5-HT(7) receptor agonists into the DRN selectively suppresses REMS in the rat. In contrast, microinjection of 5-HT(1A) receptor agonists promotes REMS. Similarly, local administration of the melanin-concentrating hormone or the GABA(A) receptor agonist muscimol produces an increase of REMS in the rat. Presently, there are no data on the effect of local infusion into the DRN of noradrenergic, dopaminergic, histaminergic, orexinergic and cholinergic agonists on sleep variables in laboratory animals.
journal_name
Sleep Med Revjournal_title
Sleep medicine reviewsauthors
Monti JMdoi
10.1016/j.smrv.2009.10.003subject
Has Abstractpub_date
2010-10-01 00:00:00pages
319-27issue
5eissn
1087-0792issn
1532-2955pii
S1087-0792(09)00099-9journal_volume
14pub_type
杂志文章,评审abstract：:This review shows that impaired/shortened sleep is a major cause of accidents in industry and transport. The reason is either sleep pathology, voluntary (non-pathological) sleep reduction, or activity during the circadian low. Night or morning work is a prominent factor with regard to the latter two. However, the link...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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journal_title：Sleep medicine reviews
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2019.05.005
更新日期：2019-10-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2005.04.004
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journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1053/smrv.2001.0177
更新日期：2002-12-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2018.07.002
更新日期：2018-12-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2010.12.001
更新日期：2011-10-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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更新日期：2019-10-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2012.04.004
更新日期：2013-02-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/smrv.2001.0220
更新日期：2003-08-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2014.07.004
更新日期：2015-06-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/S1087-0792(02)00122-3
更新日期：2004-04-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2010.10.001
更新日期：2011-08-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2005.08.001
更新日期：2006-10-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2017.10.001
更新日期：2018-06-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2009.07.005
更新日期：2010-04-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,meta分析,评审
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更新日期：2014-08-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1053/smrv.1999.0082
更新日期：1999-12-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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更新日期：2003-06-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2007.08.002
更新日期：2008-02-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2008.02.003
更新日期：2008-08-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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更新日期：2014-06-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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更新日期：2014-04-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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更新日期：2006-02-01 00:00:00
abstract：:Obstructive sleep apnea (OSA) is a common cause of daytime sleepiness for millions of Americans. It is also a disease associated with an increased likelihood of hypertension, cardiovascular disease, stroke, daytime sleepiness, motor vehicle accidents, and diminished quality of life. A number of population-based studie...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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更新日期：2008-12-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2004.09.006
更新日期：2005-04-01 00:00:00
abstract：:Nocturnal enuresis (NE) is a common condition affecting 5-10% of all 7-year-old children. NE pathophysiology relies on three main factors, abnormal bladder function, excess urine production during sleep and the inability to awaken to the signals of a full bladder. The aim of this review is to evaluate the connection b...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2019.101228
更新日期：2020-02-01 00:00:00
