Abstract：
:Daytime sleepiness and sleep disordered breathing are increased in older compared to middle-aged adults. The cognitive and cardiovascular sequelae associated with obstructive sleep apnea (OSA) have significant implications for the older adult who may already be suffering from chronic illness. Most of the evidence supporting the utilization of continuous positive airway pressure (CPAP) for the treatment of OSA has been generated from studies employing samples consisting predominately of middle-aged adults. To examine the efficacy of CPAP for the treatment of obstructive sleep apnea in older adults with an emphasis on adherence and related treatment outcomes, this paper reviews findings from clinical trials including older individuals as well as those specifically targeting this population. These studies have demonstrated that following CPAP therapy, older adults have increased alertness, improved neurobehavioral outcomes in cognitive processing, memory, and executive function, decreased sleep disruption from nocturia and a positive effect on factors affecting cardiac function, including vascular resistance, platelet coagulability and other aspects of cardiovascular health. Physiological differences in respiratory structure and function between younger and older adults of similar disease severity are believed to result in older individuals requiring titration at lower CPAP levels. Once initiated, CPAP treatment is tolerated by older adults, including those with Alzheimer's disease. Patterns of adherence in older individuals are consistent with that of middle-aged adults.
journal_name
Sleep Med Revjournal_title
Sleep medicine reviewsauthors
Weaver TE,Chasens ERdoi
10.1016/j.smrv.2006.08.001subject
Has Abstractpub_date
2007-04-01 00:00:00pages
99-111issue
2eissn
1087-0792issn
1532-2955pii
S1087-0792(06)00079-7journal_volume
11pub_type
杂志文章,评审abstract：:Sleep problems become more common with age, affect quality of life for individuals and their families, and can increase healthcare costs. Older people are often prescribed a range of drugs for their health problems, many of which have side effects. Side effects are just one reason why there is an argument to be made f...
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pub_type： 杂志文章,评审
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journal_title：Sleep medicine reviews
pub_type： 杂志文章
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pub_type： 评论,杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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