Sleep in autism: A biomolecular approach to aetiology and treatment.

Abstract:

:People with autism spectrum disorder (ASD) commonly experience other comorbidities. Studies indicate that between 50% and 83% of individuals with ASD have sleep problems or disorders. The most commonly reported sleep problems are: (a) insomnia symptoms including the inability to get to sleep or stay asleep; and (b) circadian rhythm sleep-wake disorders, defined as a misalignment between the timing of endogenous circadian rhythms and the external environment. The circadian system provides timing information for the sleep-wake cycle that is regulated by the interaction of an endogenous processes (circadian - Process C, and homeostatic - Process S) and synchronizing agents (neurohormones and neurotransmitters), which produce somnogenic activity. A clinical priority in ASD is understanding the cause of these sleep problems in order to improve treatment outcomes. This review approaches sleep in autism from several perspectives: Sleep-wake mechanisms and problems, and brain areas and molecules controlling sleep (e.g., GABA and melatonin) and wake maintenance (e.g., serotonin, acetylcholine and glutamate). Specifically, this review examines how altered sleep structure could be related to neurobiological alterations or genetic mutations and the implications this may have for potential pharmacological treatments in individuals with ASD.

journal_name

Sleep Med Rev

journal_title

Sleep medicine reviews

authors

Ballester P,Richdale AL,Baker EK,Peiró AM

doi

10.1016/j.smrv.2020.101357

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

101357

eissn

1087-0792

issn

1532-2955

pii

S1087-0792(20)30100-3

journal_volume

54

pub_type

杂志文章,评审
  • Shift work and the assessment and management of shift work disorder (SWD).

    abstract::Nearly 20% of the labor force worldwide, work shifts that include work hours outside 07:00 h to 18:00 h. Shift work is common in many occupations that directly affect the health and safety of others (e.g., protective services, transportation, healthcare), whereas quality of life, health, and safety during shift work a...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2012.02.002

    authors: Wright KP Jr,Bogan RK,Wyatt JK

    更新日期:2013-02-01 00:00:00

  • Short sleep duration predicts risk of metabolic syndrome: a systematic review and meta-analysis.

    abstract::Sleep duration has been suggested to play a key role in the development of metabolic syndrome (MS). However, the results have been inconsistent. The objective of this study was to clarify the association between sleep duration and MS risk. PubMed and Embase databases were searched for eligible publications. Pooled odd...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.smrv.2013.06.001

    authors: Xi B,He D,Zhang M,Xue J,Zhou D

    更新日期:2014-08-01 00:00:00

  • Sleep on your memory traces: How sleep effects can be explained by Act-In, a functional memory model.

    abstract::Numerous studies have explored the effect of sleep on memory. It is well known that a period of sleep, compared to a similar period of wakefulness, protects memories from interference, improves performance, and might also reorganize memory traces in a way that encourages creativity and rule extraction. It is assumed t...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2017.09.001

    authors: Cherdieu M,Versace R,Rey AE,Vallet GT,Mazza S

    更新日期:2018-06-01 00:00:00

  • Sleep quality during pregnancy: A meta-analysis.

    abstract::Women's sleep quality has been reported to change during pregnancy; prevalence estimates of poor sleep quality during pregnancy vary widely. To further understand the observed variation of findings, we conducted a meta-analysis to quantify the prevalence of poor sleep quality during pregnancy. Articles (N = 24) that r...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.smrv.2017.06.005

    authors: Sedov ID,Cameron EE,Madigan S,Tomfohr-Madsen LM

    更新日期:2018-04-01 00:00:00

  • Integrating psychology and medicine in CPAP adherence--new concepts?

    abstract::To date, continuous positive airway pressure (CPAP) is the most effective intervention in the treatment of obstructive sleep apnoea, but adherence to this treatment is often less than optimal. A variety of factors and interventions that influence and improve CPAP use have been examined. There is increasing recognition...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2013.03.002

    authors: Crawford MR,Espie CA,Bartlett DJ,Grunstein RR

    更新日期:2014-04-01 00:00:00

  • Sleep and obsessive-compulsive disorder (OCD).

    abstract::Obsessive-compulsive disorder (OCD) is a chronic mental illness that can have a debilitating effect on daily functioning. A body of research reveals altered sleep behaviour in OCD sufferers; however, findings are inconsistent and there is no consensus on the nature of this relationship. Understanding sleep disturbance...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2012.12.002

    authors: Paterson JL,Reynolds AC,Ferguson SA,Dawson D

    更新日期:2013-12-01 00:00:00

  • Adherence to positive airway pressure treatment among minority populations in the US: A scoping review.

    abstract::Minority individuals in the United States (US) have an increased prevalence of obstructive sleep apnea (OSA) compared to their white/Caucasian counterparts. In general, adherence to positive airway pressure (PAP) therapy is poor and some studies suggest that PAP use among minority individuals is inferior to that of wh...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2017.04.002

    authors: Wallace DM,Williams NJ,Sawyer AM,Jean-Louis G,Aloia MS,Vieira DL,Wohlgemuth WK

    更新日期:2018-04-01 00:00:00

  • Obstructive sleep apnea and coronary artery disease.

    abstract::In the recent years intensive research has revealed numerous negative consequences of obstructive sleep apnea (OSA) for the cardiovascular system. The pathophysiological interaction between OSA and coronary artery disease is complex and comprises neural, humoral, mechanical and haemodynamic components. One of the most...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2007.08.002

    authors: Lüthje L,Andreas S

    更新日期:2008-02-01 00:00:00

  • Sleep-related epileptic behaviors and non-REM-related parasomnias: Insights from stereo-EEG.

    abstract::During the last decade, many clinical and pathophysiological aspects of sleep-related epileptic and non-epileptic paroxysmal behaviors have been clarified. Advances have been achieved in part through the use of intracerebral recording methods such as stereo-electroencephalography (S-EEG), which has allowed a unique "i...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2015.05.002

    authors: Gibbs SA,Proserpio P,Terzaghi M,Pigorini A,Sarasso S,Lo Russo G,Tassi L,Nobili L

    更新日期:2016-02-01 00:00:00

  • Critical review: CPAP and weight management of obstructive sleep apnea cardiovascular co-morbidities.

    abstract::The cardiovascular co-morbidities of obstructive sleep apnea (OSA) are similar to those of obesity. Cardiovascular co-morbidities often are the cause of adverse outcomes in overweight/obese OSA patients. Continuous positive airway pressure (CPAP) therapy resolves the symptoms of OSA, but may, or may not lead to improv...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2016.12.001

    authors: Hudgel DW

    更新日期:2018-02-01 00:00:00

  • Incidence and prevalence of post-stroke insomnia: A systematic review and meta-analysis.

    abstract::Problems with sleep are reported to be common after stroke but the incidence and prevalence of insomnia and insomnia symptoms following stroke is not yet established. The aim of this review was to conduct a systematic review and meta-analysis of the incidence and prevalence of insomnia and insomnia symptoms in individ...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2019.101222

    authors: Baylan S,Griffiths S,Grant N,Broomfield NM,Evans JJ,Gardani M

    更新日期:2020-02-01 00:00:00

  • Insomnia as a predictor of mental disorders: A systematic review and meta-analysis.

    abstract::Previous research has identified insomnia as a predictor for the onset of depression. The aim of this meta-analysis is to investigate whether insomnia also predicts the onset of other mental disorders. Longitudinal studies were eligible for inclusion if they investigated insomnia at baseline (including nighttime- and ...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.smrv.2018.10.006

    authors: Hertenstein E,Feige B,Gmeiner T,Kienzler C,Spiegelhalder K,Johann A,Jansson-Fröjmark M,Palagini L,Rücker G,Riemann D,Baglioni C

    更新日期:2019-02-01 00:00:00

  • Development of pediatric sleep questionnaires as diagnostic or epidemiological tools: a brief review of dos and don'ts.

    abstract::Questionnaires are a useful and extensively used tool in clinical sleep medicine and in sleep research. The number of sleep questionnaires targeting the pediatric age range has tremendously increased in recent years, and with such explosion in the number of instruments, their heterogeneity has become all the more appa...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章

    doi:10.1016/j.smrv.2010.06.003

    authors: Spruyt K,Gozal D

    更新日期:2011-02-01 00:00:00

  • Effectiveness of aerobic exercise and mind-body exercise in cancer patients with poor sleep quality: A systematic review and meta-analysis of randomized controlled trials.

    abstract::Exercise has promising effects on sleep disturbances and quality of life among cancer patients. Aerobic exercises (AE) and mind-body exercises (MBE) have different mechanisms for improving sleep, but whether they are effective remains unclear. This systematic review and meta-analysis is the first to examine the effect...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2020.101334

    authors: Takemura N,Cheung DST,Smith R,Deng W,Ho KY,Lin J,Kwok JYY,Lam TC,Lin CC

    更新日期:2020-10-01 00:00:00

  • Sleep-related erections: clinical perspectives and neural mechanisms.

    abstract::Involuntary sleep-related erections (SREs) occur naturally during REM sleep in sexually potent men and other mammals. The regularity of their pattern and non-volitional nature made SREs useful clinically for differentiating psychogenic and organic erectile dysfunction (ED) in candidates for surgical intervention. Norm...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2005.03.001

    authors: Hirshkowitz M,Schmidt MH

    更新日期:2005-08-01 00:00:00

  • K-complex, a reactive EEG graphoelement of NREM sleep: an old chap in a new garment.

    abstract::This review summarises data gathered on the KC phenomenon over the past 70 yr. The following issues are discussed: definitions, morphology and topography of KC, the regular participation in NREM sleep, elicitability features of evoked KC, autonomic and motor concomitants, relationship of KC with information processing...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2005.04.003

    authors: Halász P

    更新日期:2005-10-01 00:00:00

  • Is there a clear link between overweight/obesity and sleep disordered breathing in children?

    abstract::The proportion of children who are overweight or obese has risen steadily in recent decades and approaches a quarter of all children in Western countries. This global epidemic of excess weight and adiposity in humans is associated with increased morbidity and mortality, especially related to diabetes and poor cardiova...

    journal_title:Sleep medicine reviews

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.smrv.2008.04.008

    authors: Kohler MJ,van den Heuvel CJ

    更新日期:2008-10-01 00:00:00

  • Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation.

    abstract::Restless legs syndrome (RLS)/Willis-Ekbom disease (WED) is common during pregnancy, affecting approximately one in five pregnant women in Western countries. Many report moderate or severe symptoms and negative impact on sleep. There is very little information in the medical literature for practitioners on the manageme...

    journal_title:Sleep medicine reviews

    pub_type: 共识发展会议,杂志文章,实务指引,评审

    doi:10.1016/j.smrv.2014.10.009

    authors: Picchietti DL,Hensley JG,Bainbridge JL,Lee KA,Manconi M,McGregor JA,Silver RM,Trenkwalder C,Walters AS,International Restless Legs Syndrome Study Group (IRLSSG).

    更新日期:2015-08-01 00:00:00

  • The relationship between insomnia and body temperatures.

    abstract::Sleepiness and sleep propensity are strongly influenced by our circadian clock as indicated by many circadian rhythms, most commonly by that of core body temperature. Sleep is most conducive in the temperature minimum phase, but is inhibited in a "wake maintenance zone" before the minimum phase, and is disrupted in a ...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2008.02.003

    authors: Lack LC,Gradisar M,Van Someren EJ,Wright HR,Lushington K

    更新日期:2008-08-01 00:00:00

  • Trauma-induced insomnia: A novel model for trauma and sleep research.

    abstract::Traumatic events have been increasingly recognized as important precipitants of clinically significant insomnia. Trauma is an extreme form of stressful life event that generates a sustained neurobiological response triggering the onset and maintenance of insomnia. Trauma may disrupt the normal sleep-wake regulatory me...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2015.01.008

    authors: Sinha SS

    更新日期:2016-02-01 00:00:00

  • Unattended home-based polysomnography for sleep disordered breathing: current concepts and perspectives.

    abstract::Recently, portable sleep recording devices became an accepted alternative to polysomnography (PSG) for obstructive sleep apnea (OSA) diagnosis in patients with a high pre-test probability of moderate to severe OSA but home polysomnography (H-PSG) was not recommended because there were insufficient data. The present re...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2013.12.002

    authors: Bruyneel M,Ninane V

    更新日期:2014-08-01 00:00:00

  • Pulmonary haemodynamics in obstructive sleep apnoea.

    abstract::In patients with obstructive sleep apnoea syndrome (OSAS), pulmonary haemodynamics can show both transient perturbations during sleep and permanent alterations. During sleep, repeated fluctuations in pulmonary artery pressure and pulmonary wedge pressure, coincident with apnoeas, can be observed. Calculation of transm...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1053/smrv.2001.0185

    authors: Marrone O,Bonsignore MR

    更新日期:2002-06-01 00:00:00

  • Sleep and depression in children and adolescents.

    abstract::There is considerable research evidence suggesting that sleep is biologically linked to mood disorders in adults. However, polysomographic and neuroendocrine studies in children and adolescents have not found consistent changes in sleep architecture paralleling adult major depression. This review provides a detailed d...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2004.09.006

    authors: Ivanenko A,Crabtree VM,Gozal D

    更新日期:2005-04-01 00:00:00

  • The interaction between sleep and thermoregulation in adults and neonates.

    abstract::The interaction between sleep and thermoregulation leads to different thermoregulatory responses depending on the sleep stage and alterations in sleep when in a cool or warm environment. In the human adult, differences in thermoregulatory efficiency during rapid eye movement (REM) sleep and slow wave sleep (SWS) are l...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章

    doi:10.1053/smrv.2001.0177

    authors: Bach V,Telliez F,Libert JP

    更新日期:2002-12-01 00:00:00

  • Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review.

    abstract::Magnesium supplementation is often suggested for restless legs syndrome (RLS) or period limb movement disorder (PLMD) based on anecdotal evidence that it relieves symptoms and because it is also commonly recommended for leg cramps. We aimed to review all articles reporting the effects of magnesium supplementation on c...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章

    doi:10.1016/j.smrv.2019.101218

    authors: Marshall NS,Serinel Y,Killick R,Child JM,Raisin I,Berry CM,Lallukka T,Wassing R,Lee RW,Ratnavadivel R,Vedam H,Grunstein R,Wong KK,Hoyos CM,Cayanan EA,Comas M,Chapman JL,Yee BJ

    更新日期:2019-12-01 00:00:00

  • The significance and management of persistent primary insomnia: the past, present and future of behavioral insomnia therapies.

    abstract::Persistent primary insomnia (PPI) is a prevalent and potentially serious condition that compromises the functioning, health status, and quality of lives of millions of individuals around the world. This condition is typically perpetuated by a host of psychological and behavioral mechanisms that often require behaviora...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章

    doi:10.1016/s1087-0792(99)90018-7

    authors: Edinger JD,Wohlgemuth WK

    更新日期:1999-06-01 00:00:00

  • Is there an association between attention deficit hyperactivity disorder in children and adolescents and the occurrence of bruxism? A systematic review and meta-analysis.

    abstract::Aim of the present systematic review was to evaluate whether children and adolescents with attention-deficit/hyperactivity disorder (ADHD) are at greater chance of developing bruxism compared to individuals without this disorder. Observational studies that evaluated the occurrence of bruxism in children and adolescent...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2020.101330

    authors: Souto-Souza D,Mourão PS,Barroso HH,Douglas-de-Oliveira DW,Ramos-Jorge ML,Falci SGM,Galvão EL

    更新日期:2020-10-01 00:00:00

  • Sleep deprivation and pain perception.

    abstract::Chronically painful conditions are frequently associated with sleep disturbances, i.e. changes in sleep continuity and sleep architecture as well as increased sleepiness during daytime. A new hypothesis, which has attracted more and more attention, is that disturbances of sleep cause or modulate acute and chronic pain...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2005.08.001

    authors: Lautenbacher S,Kundermann B,Krieg JC

    更新日期:2006-10-01 00:00:00

  • What works for jetlag? A systematic review of non-pharmacological interventions.

    abstract::Jetlag is a combination of travel fatigue and circadian misalignment resulting from air travel across time zones. Routinely recommended interventions based on circadian science include timely exposure to light and darkness (scheduled sleep), but the real-world effectiveness of these and other non-circadian strategies ...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章

    doi:10.1016/j.smrv.2018.09.005

    authors: Bin YS,Postnova S,Cistulli PA

    更新日期:2019-02-01 00:00:00

  • Recurrent hypersomnia: a review of 339 cases.

    abstract::Based on 339 cases this review identifies, quantifies and compares 4 clinical forms of recurrent hypersomnia (1) Kleine-Levin syndrome (KLS) (239 cases), (2) Kleine-Levin syndrome without compulsive eating (KLS WOCE) (54 cases), (3) Menstrual related hypersomnia (MRH) (18 cases) and Recurrent hypersomnia with comorbid...

    journal_title:Sleep medicine reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.smrv.2010.08.001

    authors: Billiard M,Jaussent I,Dauvilliers Y,Besset A

    更新日期:2011-08-01 00:00:00