Abstract:
:People with autism spectrum disorder (ASD) commonly experience other comorbidities. Studies indicate that between 50% and 83% of individuals with ASD have sleep problems or disorders. The most commonly reported sleep problems are: (a) insomnia symptoms including the inability to get to sleep or stay asleep; and (b) circadian rhythm sleep-wake disorders, defined as a misalignment between the timing of endogenous circadian rhythms and the external environment. The circadian system provides timing information for the sleep-wake cycle that is regulated by the interaction of an endogenous processes (circadian - Process C, and homeostatic - Process S) and synchronizing agents (neurohormones and neurotransmitters), which produce somnogenic activity. A clinical priority in ASD is understanding the cause of these sleep problems in order to improve treatment outcomes. This review approaches sleep in autism from several perspectives: Sleep-wake mechanisms and problems, and brain areas and molecules controlling sleep (e.g., GABA and melatonin) and wake maintenance (e.g., serotonin, acetylcholine and glutamate). Specifically, this review examines how altered sleep structure could be related to neurobiological alterations or genetic mutations and the implications this may have for potential pharmacological treatments in individuals with ASD.
journal_name
Sleep Med Revjournal_title
Sleep medicine reviewsauthors
Ballester P,Richdale AL,Baker EK,Peiró AMdoi
10.1016/j.smrv.2020.101357subject
Has Abstractpub_date
2020-12-01 00:00:00pages
101357eissn
1087-0792issn
1532-2955pii
S1087-0792(20)30100-3journal_volume
54pub_type
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journal_title:Sleep medicine reviews
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journal_title:Sleep medicine reviews
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,meta分析,评审
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journal_title:Sleep medicine reviews
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journal_title:Sleep medicine reviews
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journal_title:Sleep medicine reviews
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pub_type: 杂志文章,meta分析
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journal_title:Sleep medicine reviews
pub_type: 评论,杂志文章,评审
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pub_type: 共识发展会议,杂志文章,实务指引,评审
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pub_type: 杂志文章,评审
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