Abstract：
:Sleep and sleep disorders are complex and highly variable phenotypes regulated by many genes and environment. The catechol-O-methyltransferase (COMT) gene is an interesting candidate, being one of the major mammalian enzymes involved in the catabolism of catecholamines. The activity of COMT enzyme is genetically polymorphic due to a guanine-to-adenine transition at codon 158, resulting in a valine (Val) to methionine (Met) substitution. Individuals homozygous for the Val allele show higher COMT activity, and lower dopaminergic signaling in prefrontal cortex (PFC) than subjects homozygous for the Met allele. Since COMT has a crucial role in metabolising dopamine, it was suggested that the common functional polymorphism in the COMT gene impacts on cognitive function related to PFC, sleep-wake regulation, and potentially on sleep pathologies. The COMT Val158Met polymorphism may predict inter-individual differences in brain electroencephalography (EEG) alpha oscillations and recovery processes resulting from partial sleep loss in healthy individuals. The Val158Met polymorphism also exerts a sexual dimorphism and has a strong effect on objective daytime sleepiness in patients with narcolepsy-cataplexy. Since the COMT enzyme inactivates catecholamines, it was hypothesized that the response to stimulant drugs differs between COMT genotypes. Modafinil maintained executive functioning performance and vigilant attention throughout sleep deprivation in subjects with Val/Val genotype, but less in those with Met/Met genotype. Also, homozygous Met/Met patients with narcolepsy responded to lower doses of modafinil compared to Val/Val carriers. We review here the critical role of the common functional COMT gene polymorphism, COMT enzyme activity, and the prefrontal dopamine levels in the regulation of sleep and wakefulness in normal subjects, in narcolepsy and other sleep-related disorders, and its impact on the response to psychostimulants.
journal_name
Sleep Med Revjournal_title
Sleep medicine reviewsauthors
Dauvilliers Y,Tafti M,Landolt HPdoi
10.1016/j.smrv.2014.10.006subject
Has Abstractpub_date
2015-08-01 00:00:00pages
47-53eissn
1087-0792issn
1532-2955pii
S1087-0792(14)00116-6journal_volume
22pub_type
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journal_title：Sleep medicine reviews
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journal_title：Sleep medicine reviews
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journal_title：Sleep medicine reviews
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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journal_title：Sleep medicine reviews
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journal_title：Sleep medicine reviews
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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更新日期：2018-10-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1016/s1087-0792(99)90014-x
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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更新日期：2015-12-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2013.03.002
更新日期：2014-04-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/smrv.2001.0185
更新日期：2002-06-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2009.07.005
更新日期：2010-04-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2007.08.002
更新日期：2008-02-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2008.11.001
更新日期：2009-10-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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更新日期：2013-02-01 00:00:00
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journal_title：Sleep medicine reviews
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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journal_title：Sleep medicine reviews
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2010.12.001
更新日期：2011-10-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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更新日期：2018-02-01 00:00:00
abstract：:Recent evidence suggests that air pollution exposure may be a contributing risk factor for obstructive sleep apnea (OSA), however, current evidence is conflicting. This systematic review aims to determine the association between air pollution and OSA in the general population, and examine for potential effect modifica...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
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更新日期：2020-12-01 00:00:00
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journal_title：Sleep medicine reviews
pub_type： 杂志文章
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更新日期：1999-12-01 00:00:00
abstract：:Cognitive deficits and cardiovascular disease (CVD) are comorbid conditions frequently associated with obstructive sleep apnea (OSA). Oxygen free radical release and its differential regulation of cytokine synthesis and immune modulation resulting from OSA-related hypoxic events have been hypothesized as the underlyin...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2005.04.004
更新日期：2005-12-01 00:00:00
