Abstract：
:Magnesium supplementation is often suggested for restless legs syndrome (RLS) or period limb movement disorder (PLMD) based on anecdotal evidence that it relieves symptoms and because it is also commonly recommended for leg cramps. We aimed to review all articles reporting the effects of magnesium supplementation on changes in RLS and/or PLMD. We conducted a systematic search looking for all relevant articles and then two reviewers read all article titles and abstracts to identify relevant studies. Eligible studies were scored for their quality as interventional trials. We found 855 abstracts and 16 of these could not be definitively excluded for not addressing all aspects of our research question. Seven full-text articles were unlocatable and one was ineligible which left eight studies with relevant data. One was a randomised placebo-controlled trial, three were case series and four were case studies. The RCT did not find a significant treatment effect of magnesium but may have been underpowered. After quality appraisal and synthesis of the evidence we were unable to make a conclusion as to the effectiveness of magnesium for RLS/PLMD. It is not clear whether magnesium helps relieve RLS or PLMD or in which patient groups any benefit might be seen.
journal_name
Sleep Med Revjournal_title
Sleep medicine reviewsauthors
Marshall NS,Serinel Y,Killick R,Child JM,Raisin I,Berry CM,Lallukka T,Wassing R,Lee RW,Ratnavadivel R,Vedam H,Grunstein R,Wong KK,Hoyos CM,Cayanan EA,Comas M,Chapman JL,Yee BJdoi
10.1016/j.smrv.2019.101218subject
Has Abstractpub_date
2019-12-01 00:00:00pages
101218eissn
1087-0792issn
1532-2955pii
S1087-0792(19)30186-8journal_volume
48pub_type
杂志文章abstract：:This review is concerned with circadian (approximately 24 h) aspects of chronobiology, and how they relate to sleep disorders medicine. We begin with an introduction to the key concepts and paradigms of circadian rhythms research in general, including a description of homeostatic and circadian determinants of sleep ti...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/s1087-0792(03)90001-3
更新日期：2003-12-01 00:00:00
abstract：:The psychiatric intervention, light therapy, grew from an intensive 25-year research focus on seasonal affective disorder (SAD). Dosing and timing strategies have been honed to optimize the antidepressant effect, and efficacy relative to placebo has provided the evidence base for widespread implementation. A persisten...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2007.06.003
更新日期：2007-12-01 00:00:00
abstract：:The objective of this systematic review and content analysis was to identify and quantify the concepts contained in patient-administered health status measures in sleep medicine practice and research using the International Classification of Functioning, Disability and Health (ICF) as a reference. Both generic and con...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2010.07.001
更新日期：2011-02-01 00:00:00
abstract：:After major non-cardiac surgery sleep pattern is usually disturbed with initial suppression of rapid eye movement sleep with a subsequent rebound during the first post-operative week. Deep sleep is also suppressed for several days after the operation and subjective sleep quality is impaired. The sleep disturbances see...
journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1053/smrv.2000.0121
更新日期：2001-04-01 00:00:00
abstract：:Obstructive sleep apnea/hypopnea (OSAH) syndrome is a highly prevalent condition. Severe OSAH affects 2-6% of the population, although only 10% of subjects are correctly diagnosed and treated. OSAH is an important and unresolved public health care problem because of its role in the development of cardiovascular events...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2008.11.001
更新日期：2009-10-01 00:00:00
abstract：:Questionnaires are a useful and extensively used tool in clinical sleep medicine and in sleep research. The number of sleep questionnaires targeting the pediatric age range has tremendously increased in recent years, and with such explosion in the number of instruments, their heterogeneity has become all the more appa...
journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1016/j.smrv.2010.06.003
更新日期：2011-02-01 00:00:00
abstract：:Cognitive deficits and cardiovascular disease (CVD) are comorbid conditions frequently associated with obstructive sleep apnea (OSA). Oxygen free radical release and its differential regulation of cytokine synthesis and immune modulation resulting from OSA-related hypoxic events have been hypothesized as the underlyin...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2005.04.004
更新日期：2005-12-01 00:00:00
abstract：:In addition to its role in vision, light exerts strong effects on behavior. Its powerful role in the modulation of mood is well established, yet remains poorly understood. Much research has focused on the effects of light on circadian rhythms and subsequent interaction with alertness and depression. The recent discove...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2011.09.002
更新日期：2012-10-01 00:00:00
abstract：:Sleepiness and fatigue are two interrelated, but distinct phenomena; observed in a number of psychiatric, medical and primary sleep disorders. Despite their different implications in terms of diagnosis and treatment, these two terms are often used interchangeably, or merged under the more general lay term of 'tired'. ...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2005.05.004
更新日期：2006-02-01 00:00:00
abstract：:Vitamin D insufficiency is common in the healthy population. Recent insights addressed the role of vitamin D in serotonin and melatonin regulation, suggesting that increasing vitamin D status may be helpful for improving mood and sleep. This literature review covers the current state of evidence regarding potential ef...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2020.101379
更新日期：2021-02-01 00:00:00
abstract：:Dopaminergic drugs have been widely used over the last decades for the treatment of restless legs syndrome (RLS)/Willis-Ekbom disease (WED). While the majority of studies show an initial improvement in symptoms, longer studies and clinical experience show that either treatment efficacy decreases with time, and/or augm...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2018.01.001
更新日期：2018-10-01 00:00:00
abstract：:Opioid use whether acute or chronic, illicit or therapeutic is prevalent in Western societies. Opioid receptors are located in the same nuclei that are active in sleep regulation and opioid peptides are suggested to be involved in the induction and maintenance of the sleep state. mu-Opioids are the most commonly used ...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2006.03.006
更新日期：2007-02-01 00:00:00
abstract：:Daytime sleepiness and sleep disordered breathing are increased in older compared to middle-aged adults. The cognitive and cardiovascular sequelae associated with obstructive sleep apnea (OSA) have significant implications for the older adult who may already be suffering from chronic illness. Most of the evidence supp...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2006.08.001
更新日期：2007-04-01 00:00:00
abstract：:Problems with sleep are reported to be common after stroke but the incidence and prevalence of insomnia and insomnia symptoms following stroke is not yet established. The aim of this review was to conduct a systematic review and meta-analysis of the incidence and prevalence of insomnia and insomnia symptoms in individ...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2019.101222
更新日期：2020-02-01 00:00:00
abstract：:Obesity is prevalent among pregnant women in the United States; 15-20% of obese pregnant women have obstructive sleep apnea. The prevalence of obstructive sleep apnea increases along with body mass index, age and in the presence of other co-morbidities. Untreated obstructive sleep apnea in women is associated with a r...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2018.05.004
更新日期：2018-12-01 00:00:00
abstract：:In patients with obstructive sleep apnoea syndrome (OSAS), pulmonary haemodynamics can show both transient perturbations during sleep and permanent alterations. During sleep, repeated fluctuations in pulmonary artery pressure and pulmonary wedge pressure, coincident with apnoeas, can be observed. Calculation of transm...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1053/smrv.2001.0185
更新日期：2002-06-01 00:00:00
abstract：:In the recent years intensive research has revealed numerous negative consequences of obstructive sleep apnea (OSA) for the cardiovascular system. The pathophysiological interaction between OSA and coronary artery disease is complex and comprises neural, humoral, mechanical and haemodynamic components. One of the most...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2007.08.002
更新日期：2008-02-01 00:00:00
abstract：:Post-operative patients experience sleep disturbances. Animal studies demonstrate that general anaesthesia (GA) can disrupt circadian rhythms and cause changes in the molecular clock, indicating that anaesthesia contributes to post-operative circadian disruption. Here we review the effect of anaesthesia on the circadi...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2016.12.002
更新日期：2018-02-01 00:00:00
abstract：:During the last decade, many clinical and pathophysiological aspects of sleep-related epileptic and non-epileptic paroxysmal behaviors have been clarified. Advances have been achieved in part through the use of intracerebral recording methods such as stereo-electroencephalography (S-EEG), which has allowed a unique "i...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2015.05.002
更新日期：2016-02-01 00:00:00
abstract：:Evidence suggests that sleep disorders and sleep fragmentation are very common in nursing home residents. A variety of factors contribute to these sleeping difficulties, including age-related changes in sleep; the high prevalence of dementia, depression, medical illness and medications that affect sleep; and sleep dis...
journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1053/smrv.1999.0066
更新日期：2000-02-01 00:00:00
abstract：:The process of falling asleep can best be measured by considering a convergence of behavioural, EEG, physiological and subjective information. Doing so allows one to see sleep processes as they unfold, but relying on any single sleep index can bias the description of this complex process. The studies reviewed do not s...
journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1053/smrv.2001.0145
更新日期：2001-06-01 00:00:00
abstract：:Mammalian sleep emerges from attenuated activity in the ascending reticular arousal system (ARAS), the main arousal network of the brain. This system originates in the brainstem and activates the thalamus and cortex during wakefulness via a well-characterized 'bottom-up' pathway. Recent studies propose that a less inv...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2015.12.005
更新日期：2017-02-01 00:00:00
abstract：:Sleep problems become more common with age, affect quality of life for individuals and their families, and can increase healthcare costs. Older people are often prescribed a range of drugs for their health problems, many of which have side effects. Side effects are just one reason why there is an argument to be made f...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/S1087-0792(03)00026-1
更新日期：2004-02-01 00:00:00
abstract：:Jetlag is a combination of travel fatigue and circadian misalignment resulting from air travel across time zones. Routinely recommended interventions based on circadian science include timely exposure to light and darkness (scheduled sleep), but the real-world effectiveness of these and other non-circadian strategies ...
journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1016/j.smrv.2018.09.005
更新日期：2019-02-01 00:00:00
abstract：:The proportion of children who are overweight or obese has risen steadily in recent decades and approaches a quarter of all children in Western countries. This global epidemic of excess weight and adiposity in humans is associated with increased morbidity and mortality, especially related to diabetes and poor cardiova...
journal_title：Sleep medicine reviews
pub_type： 评论,杂志文章,评审
doi：10.1016/j.smrv.2008.04.008
更新日期：2008-10-01 00:00:00
abstract：:This review is aimed at summarizing the current state of knowledge regarding parasomnias, which have been implicated in medicolegal cases as well as providing guidance to those working within common-law jurisdictions regarding the technical aspects of the law. Sleepwalking and sexsomnia as a defence are being raised m...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2013.07.004
更新日期：2014-06-01 00:00:00
abstract：:The interaction between sleep and thermoregulation leads to different thermoregulatory responses depending on the sleep stage and alterations in sleep when in a cool or warm environment. In the human adult, differences in thermoregulatory efficiency during rapid eye movement (REM) sleep and slow wave sleep (SWS) are l...
journal_title：Sleep medicine reviews
pub_type： 杂志文章
doi：10.1053/smrv.2001.0177
更新日期：2002-12-01 00:00:00
abstract：:Allergic rhinitis is a very prevalent disease in developed nations and has been increasing throughout the world. Nasal congestion is one of the most common and bothersome symptoms of rhinitis in both children and adults. Congestion is associated with sleep-disordered breathing and is thought to be a key cause of sleep...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2010.12.001
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVES:Sleep problems are a potential risk factor for work injuries but the extent of the risk is unclear. We conducted a systematic review and meta-analysis to quantify the effect of sleep problems on work injuries. METHODS:A systematic literature search using several databases was performed. Sleep problems of an...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.smrv.2013.01.004
更新日期：2014-02-01 00:00:00
abstract：:Prevalence of both chronic kidney disease (CKD) and obstructive sleep apnea (OSA) is continuously increasing. Moreover, the prevalence of OSA increases as kidney function declines and is higher among patients with end-stage renal disease (ESRD). In addition, OSA is recognized as a potential nontraditional risk factor ...
journal_title：Sleep medicine reviews
pub_type： 杂志文章,评审
doi：10.1016/j.smrv.2019.07.001
更新日期：2019-10-01 00:00:00
