Abstract：
:In patients with obstructive sleep apnoea syndrome (OSAS), pulmonary haemodynamics can show both transient perturbations during sleep and permanent alterations. During sleep, repeated fluctuations in pulmonary artery pressure and pulmonary wedge pressure, coincident with apnoeas, can be observed. Calculation of transmural pressure values is preferable to intravascular pressures in OSAS, due to the marked swings in intrathoracic pressure associated with obstructive apnoeas. Pulmonary artery pressure may progressively increase during sleep, particularly in close sequences of highly desaturating apnoeas. Apnoea-induced hypoxia appears as the most important determinant of this pulmonary artery pressure behaviour. Stroke volume and cardiac output during obstructive apnoeas show changes mainly related to intrathoracic pressure variations. Permanent precapillary pulmonary hypertension at rest is observed in <50% OSAS patients, and is poorly reversible after OSAS treatment. It correlates best with diurnal respiratory function parameters. However, the finding of pulmonary hypertension in some patients with near normal diurnal lung function led to suggest that sleep respiratory disorders may contribute to permanent pulmonary haemodynamic impairment in predisposed subjects. Knowledge on right ventricle hypertrophy in OSAS is inconsistent. As to right ventricle failure, it is clinically evident in subjects with associated lung disease or morbid obesity, while it may be detected instrumentally in subjects without such alterations, presumably as effect of apnoeas themselves. Besides, it appears more fully reversible after long-term OSAS treatment than pulmonary hypertension.
journal_name
Sleep Med Revjournal_title
Sleep medicine reviewsauthors
Marrone O,Bonsignore MRdoi
10.1053/smrv.2001.0185subject
Has Abstractpub_date
2002-06-01 00:00:00pages
175-93issue
3eissn
1087-0792issn
1532-2955pii
S1087079201901856journal_volume
6pub_type
杂志文章,评审abstract：:Polysomnography has been accepted by many as a "gold standard" for the diagnosis of the Obstructive Sleep Apnoea/Hypopnoea Syndrome (OSAHS). Although polysomnography is a good method for diagnosing OSAHS, there is no evidence that the results of polysomnography more accurately identify patients with the syndrome than ...
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pub_type： 评论,杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Sleep medicine reviews
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2003-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2005-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1053/smrv.1999.0082
更新日期：1999-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s1087-0792(97)90002-2
更新日期：1997-11-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,meta分析,评审
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更新日期：2015-10-01 00:00:00
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pub_type： 杂志文章
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