Abstract:
:Disrupted nighttime sleep is one of the pentad of symptoms defining Narcolepsy. REM sleep behavior disorder (RBD) largely contributes to night sleep disruption and narcolepsy is the most common cause of secondary RBD. However, RBD linked to narcolepsy (N-RBD) has been insufficiently characterized, leaving unsolved a number of issues. Indeed, it is still debated whether N-RBD is an intrinsic feature of narcolepsy, as indubitable for cataplexy, and therefore strictly linked to the cerebrospinal fluid hypocretin-1 (CSF hcrt-1) deficiency, or an associated feature, with a still unclear pathophysiology. The current review aims at rendering a comprehensive state-of-the-art of N-RBD, highlighting the open and unsettled topics. RBD reportedly affects 30-60% of patients with Narcolepsy type 1 (NT1), but it may be seen also in Narcolepsy type 2 (NT2). When compared to idiopathic/isolated RBD (iRBD), N-RBD has been reported to be characterized by less energetic and quieter episode, which however occur with the same probability in the first and the second part of the night and sometime even subcontinuously. N-RBD patients are generally younger than those with iRBD. N-RBD has been putatively linked to wake-sleep instability due to CSF hcrt-1 deficiency, but this latter by itself cannot explain completely the phenomenon as N-RBD has not been universally linked to low CSF hcrt-1 levels and it may be observed also in NT2. Therefore, other factors may probably play a role and further studies are needed to clarify this issue. In addition, therapeutic options have been poorly investigated.
journal_name
Sleep Med Revjournal_title
Sleep medicine reviewsauthors
Antelmi E,Pizza F,Franceschini C,Ferri R,Plazzi Gdoi
10.1016/j.smrv.2019.101254subject
Has Abstractpub_date
2020-04-01 00:00:00pages
101254eissn
1087-0792issn
1532-2955pii
S1087-0792(19)30222-9journal_volume
50pub_type
杂志文章,评审abstract::Results from the present review challenge the assumption that daytime functioning deficits are associated with insomnia. Objectively-measured daytime sleepiness is not elevated in people with insomnia, and most cognitive/psychomotor tasks do not indicate deficits in people with insomnia. In contrast, a number of studi...
journal_title:Sleep medicine reviews
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journal_title:Sleep medicine reviews
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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更新日期:2005-08-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2010.03.002
更新日期:2011-04-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2018.02.004
更新日期:2018-10-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2013.03.002
更新日期:2014-04-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2015.12.005
更新日期:2017-02-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2006.08.001
更新日期:2007-04-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Sleep medicine reviews
pub_type: 杂志文章
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journal_title:Sleep medicine reviews
pub_type: 杂志文章
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journal_title:Sleep medicine reviews
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journal_title:Sleep medicine reviews
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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journal_title:Sleep medicine reviews
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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