Abstract:
:Glucocorticoids and statins are the foundation of lifelong therapies and as such, may generate a variety of side effects. Among these, sleep impairments are one of the least explored and, simultaneously, majorly underestimated in clinical practice. Based on the available evidence, we have concluded that glucocorticoid action on the suprachiasmatic nucleus (SCN) that drives sleep disturbances is dual in nature. It involves both serotonin depletion and reduced arginine vasopressin signalling in the SCN. The former seems to involve activation of glucocorticoid receptors in the dorsal raphe, whereas the latter likely results from changes in glucose serum levels affecting the SCN, among other blood-borne factors which are yet to be discovered. Literature remains inconclusive when it comes to statins. Their diverse potential to cross the blood-brain barrier is considered the key factor determining statins' capability to evoke sleep impairments. Concurrently, an effect similar to that produced by steroids occurs - alteration in serum levels of blood-borne factors, such as glucose, which is a likely cause of statin-induced sleep disturbances.
journal_name
Sleep Med Revjournal_title
Sleep medicine reviewsauthors
Szmyd B,Rogut M,Białasiewicz P,Gabryelska Adoi
10.1016/j.smrv.2020.101380subject
Has Abstractpub_date
2021-02-01 00:00:00pages
101380eissn
1087-0792issn
1532-2955pii
S1087-0792(20)30123-4journal_volume
55pub_type
杂志文章,评审abstract::Persistent primary insomnia (PPI) is a prevalent and potentially serious condition that compromises the functioning, health status, and quality of lives of millions of individuals around the world. This condition is typically perpetuated by a host of psychological and behavioral mechanisms that often require behaviora...
journal_title:Sleep medicine reviews
pub_type: 杂志文章
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journal_title:Sleep medicine reviews
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journal_title:Sleep medicine reviews
pub_type: 杂志文章
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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journal_title:Sleep medicine reviews
pub_type: 杂志文章
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journal_title:Sleep medicine reviews
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2016.06.001
更新日期:2017-06-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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更新日期:2017-04-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2018.03.008
更新日期:2018-10-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2011.06.002
更新日期:2012-04-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章
doi:10.1016/s1087-0792(98)90020-x
更新日期:1998-08-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2007.06.004
更新日期:2007-12-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2018.05.004
更新日期:2018-12-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2015.12.005
更新日期:2017-02-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2016.07.002
更新日期:2017-08-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2007.08.002
更新日期:2008-02-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2020.101360
更新日期:2020-12-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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更新日期:2016-02-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2010.12.001
更新日期:2011-10-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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更新日期:2002-02-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章
doi:10.1016/j.smrv.2018.09.005
更新日期:2019-02-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2018.02.004
更新日期:2018-10-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1016/j.smrv.2013.12.002
更新日期:2014-08-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章
doi:10.1053/smrv.1999.0074
更新日期:2000-06-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
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更新日期:2021-02-01 00:00:00
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journal_title:Sleep medicine reviews
pub_type: 杂志文章,评审
doi:10.1053/smrv.2001.0220
更新日期:2003-08-01 00:00:00