Abstract:
:For a number of years now, we have argued that current models for the control of initiation of DNA synthesis, chromosomal partitioning and septum formation in Escherichia coli are unsatisfactory. Indeed, we could argue that despite considerable efforts, with the possible exception of dnaA and ftsZ, no genes specifically implicated in these control processes have been identified. In the cases of DnaA and FtsZ, no evidence has appeared to indicate how such molecules might be regulated to act once per cycle. In 1988, we formulated a specific proposal that the timing of cell cycle events in E. coli might be determined by a Ca++ flux, mediated by calcium-binding proteins and protein kinases and culminating, in the case of chromosome segregation and division, in the action of force-generating proteins such as myosin (Norris et al., 1988). In formulating this proposal, we took the view that the fundamental elements of cell cycle regulation are likely to be highly conserved across all species including prokaryotes. In this presentation, we shall describe the approaches we have been taking in order to test this hypothesis and to summarize the data obtained, in particular in relation to new genes identified which may play a role in the E. coli cell cycle. We shall also briefly indicate recent data from other laboratories consistent with our general hypothesis.
journal_name
Res Microbioljournal_title
Research in microbiologyauthors
Casaregola S,Chen M,Bouquin N,Norris V,Jacq A,Goldberg M,Margarson S,Tempete M,Mckenna S,Sweetman Hdoi
10.1016/0923-2508(91)90031-5subject
Has Abstract,Author List Incompletepub_date
1991-02-01 00:00:00pages
201-7issue
2-3eissn
0923-2508issn
1769-7123pii
0923-2508(91)90031-5journal_volume
142pub_type
杂志文章abstract::An aerotolerant, psychrotolerant anaerobe, anNAG3, was isolated from an acidic forest floor solution (in situ pH of 4.5). Cells of anNAG3 stained Gram-positive did not form spores, and were not motile. Cells were ovoid, approximately 1 microm long and 0.7 microm wide, mostly in pairs, and contained a multi-layered cel...
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journal_title:Research in microbiology
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pub_type: 杂志文章
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journal_title:Research in microbiology
pub_type: 杂志文章
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journal_title:Research in microbiology
pub_type: 杂志文章
doi:10.1016/j.resmic.2015.01.003
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pub_type: 杂志文章
doi:10.1016/s0923-2508(99)80020-5
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journal_title:Research in microbiology
pub_type: 杂志文章
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journal_title:Research in microbiology
pub_type: 杂志文章
doi:10.1016/0923-2508(93)90210-s
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journal_title:Research in microbiology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Research in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0923-2508(92)90117-7
更新日期:1992-07-01 00:00:00
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journal_title:Research in microbiology
pub_type: 杂志文章,评审
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journal_title:Research in microbiology
pub_type: 杂志文章
doi:10.1016/j.resmic.2004.04.007
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journal_title:Research in microbiology
pub_type: 杂志文章
doi:10.1016/j.resmic.2012.10.005
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journal_title:Research in microbiology
pub_type: 杂志文章
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journal_title:Research in microbiology
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journal_title:Research in microbiology
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doi:10.1016/j.resmic.2012.02.003
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journal_title:Research in microbiology
pub_type: 杂志文章
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journal_title:Research in microbiology
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journal_title:Research in microbiology
pub_type: 杂志文章
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journal_title:Research in microbiology
pub_type: 杂志文章
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journal_title:Research in microbiology
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